ABSTRACT
Objective To investigate the influence of long-term exposure to oil and gas toxicants on the peripheral blood T lym-phocyte subsets in Karamay Uygur and Han refining workers and the underlying mechanism.Methods 175 cases of Uighur and Han refinery workers who had long-term close contact with poison of oil and gas(112 cases of Han people and 63 cases of Uygur people)and 110 healthy people(70 cases of Han people,40 cases of Uighur)were selected as research subject.The peripheral blood T lymphocyte subsets of all cases were detected for comparative analysis.Results Compared with healthy control group,the median of CD4+in the uighur refinery workers was significantly reduced(P<0.05);the CD8+in Han ethnic refinery workers was signifi-cantly lower,while the ratio of CD4+/CD8+increased significantly(P<0.05).Compared with Han ethnic,the median of CD3+, CD8+in uighur significantly increased,while the ratio of CD4+/CD8+decreased significantly(P<0.05).Conclusion Long-term close contact(more than 5 years)of oil and gas poison will significantly reduce the function of peripheral blood T lymphocyte sub-sets of refinery workers,and the effect on Han ethnic oil refinery workers was significantly higher than that on Uighur,,so corre-sponding measures on effective occupational protection are necessary to carry out.
ABSTRACT
Objective: To identify the differential expression of human leukocyte antigen I (HLA-I) between patients of Uighur and Han ethnic groups with cervical diseases. Methods: The expression levels of HLA-I protein in chronic cervicitis, cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma (CSCC) tissues from female patients of Uighur and Han ethnic groups were examined by immunohistochemistry method. Results: The expressions of HLA-I protein in chronic cervicitis, CIN and CSCC tissues were normal, partial-lost and negative, respectively. The total loss rates of HLA-I protein expression were 2% (1/49), 26% (29/113) and 49% (34/70) in chronic cervicitis, CIN and CSCC tissues, respectively (P<0.05). The increasing tendency of total loss rate of HLA-I protein expression accompanied by the enhancement of cervical disease severity in the Uighur ethnic group was similar to that of the Han ethnic group. The total loss rates of HLA-I protein expression in CIN and CSCC tissues were both higher in Uighur women (27% and 53%, respectively) than those in Han women (18% and 37%, respectively). Conclusion: The loss of HLA-I protein expression may predict the progression of cervical cancer. The differential expression of HLA I between Uighur and Han ethnic groups may reflect the different genetic pathways of carcinogenesis.