Relación entre la tasa metabólica basal con proteína C reactiva ultrasensible y variables antropométricas en adolescentes / Relationship between basal metabolic rate with ultrasensitive C-reactive protein and anthropometric variables in adolescents

La obesidad es un problema de la salud pública que disminuye la esperanza de vida y genera altos costos sociales y económicos. La tendencia ha sido creciente a nivel mundial con un aumento superior al 75% en los últimos años. El objetivo fue relacionar el metabolismo basal con niveles séricos de proteína C reactiva ultrasensible y variables antropométricas en adolescentes. Se trata de un estudio correlacional, con un diseño no experimental. La muestra fue no probabilística, participaron 33 adolescentes, 13 mujeres y 20 hombres entre 12 a 16 años, entre mayo y diciembre de 2018. Se midió el metabolismo basal, actividad física, variables antropométricas y niveles de proteína C reactiva ultrasensible. Los datos fueron analizados con estadística descriptiva e inferencial y se utilizó el coeficiente de correlación lineal de Pearson, con un nivel de significancia <0,05. Se encontró 66,7% de sobrepeso y obesidad, calculado con el índice de masa corporal, (según puntaje Z ≥ 1). El 78,8% de la muestra presentó un porcentaje de grasa corporal elevado, la proteína C reactiva se encontró elevada en el 18,2% de la muestra, con un promedio de 2,0 mg/dl y, la correlación entre el metabolismo basal y la proteína C reactiva ultrasensible obtuvo un valor r=0,18 y un valor p=0,63. Se concluye que en este grupo de adolescentes la correlación entre el metabolismo basal y la proteína C reactiva ultrasensible fue débil, sin embargo, existe una moderada asociación entre el metabolismo basal y el porcentaje de masa magra, reafirmando la importancia de este tejido como un órgano metabólico activo(AU)

Obesity is a public health problem that decreases life expectancy and generates high social and economic costs. The trend has been increasing worldwide with an increase of over 75% in recent years. The objective was to relate the basal metabolism with serum levels of ultrasensitive C-reactive protein and anthropometric variables in adolescent subjects. It is a correlational study, with a non-experimental design. A non-probabilistic sample of 33 adolescents, 13 women and 20 men, between 12 and 16 years old, were evaluated between the months of May to December 2018. Basal metabolism, physical activity, anthropometric variables and levels of ultrasensitive C-reactive protein were measured. The data were analyzed with descriptive and inferential statistics; Pearson's linear correlation coefficient was used, with a level of significance <0.05. A 66.7% of overweight and obesity was found, calculated with the body mass index, (according to Z score ≥ 1). 78.8% of the sample presented a high percentage of body fat, C-reactive protein was found high in 18.2% of the sample, with an average of 2.0 mg/dl and, the correlation between metabolism baseline and the ultrasensitive C-reactive protein obtained a value r = 0.18 and a value p = 0.63. It is concluded that in this group of adolescents the correlation between basal metabolism and ultrasensitive C-reactive protein was weak; however, there is a moderate association between basal metabolism and lean mass percentage, reaffirming the importance of this tissue as an organ active metabolic(AU)

Proteína C ultrasensible como factor independiente de riesgo en población con y sin antecedentes cardiovasculares / High sensitivity C protein as an independent risk factor in people with and without history of cardiovascular disease

Entre los nuevos biomarcadores del riesgo de eventos cardiovasculares (ECV), la proteína C reactiva detectada mediante técnicas de alta sensibilidad (PCRus) ha sido uno de los más evaluados. En esta revisión se exploró la evidencia existente sobre la utilidad de la PCRus como factor independiente del riesgo de eventos en sujetos sin antecedentes cardiovasculares, y como marcador pronóstico en sujetos con enfermedad cardiovascular crónica o aguda. Se realizó un overview (revisión de revisiones) con búsqueda en las principales bases bibliográficas suplementada por buscadores genéricos de Internet. En una primera etapa se detectaron revisiones sistemáticas, guías de práctica clínica, evaluaciones de tecnologías sanitarias y políticas de cobertura, y en una segunda etapa se identificaron estudios primarios publicados posteriormente a las fechas de búsqueda de las revisiones sistemáticas. Fueron recuperadas 774 citas, de las cuales se incluyeron 36 publicaciones que evaluaron el papel de la PCRus en poblaciones sanas o con antecedentes coronarios. Se encontró evidencia de alta calidad señalando a la PCRus, tanto como factor de riesgo en población general, como pronóstico en aquellos con ECV en todas las poblaciones evaluadas. Su mayor utilidad residió en sujetos sin historia de ECV y riesgo intermedio de eventos a 10 años, en donde la adición de la PCRus a modelos clásicos de estimación del riesgo de eventos mejora la estratificación del riesgo. No se identificó, en cambio, consenso sobre su utilidad clínica como marcador pronóstico en sujetos con enfermedad coronaria crónica o aguda.

Among the new cardiovascular event (CVE) risk biomarkers, C-reactive protein detected using high sensitive techniques (hs-CRP) has been one of the most commonly evaluated. In this review, the available evidence on the usefulness of hs-CRP was explored as an independent risk event factor in subjects with no cardiovascular history and as prognosis in case of chronic or acute cardiovascular condition. An overview (revision of revisions) was carried out searching in the main bibliographic databases and in other general Internet search engines. During the first stage, systematic reviews, clinical practice guidelines, health technology assessments and coverage policies were found and, during the second stage primary studies published after the systematic review search dates were added. Seven hundred and seventy four quotes were found, including 36 papers assessing the role of hs-CRP in healthy populations or with cardiovascular history. High quality evidence was found pointing out hs-CRP, both as risk factor in the general population and as prognostic factor in those with CVE, in all the populations assessed. It was most useful in subjects with a history of CVE and intermediate risk of events at 10 years; where adding hs-CRP to the classical models for event risk estimation improves risk staging. There was no consensus on its clinical usefulness as a prognostic marker in subjects with chronic or acute disease.

Inflammation and oxidative stress in hypothyroids: Additive effects on cardiovascular risk.

Cardiovascular disease is one of the major complications of hypothyroidism which is one of the most common endocrine disorders in India. In the present study, we have analyzed the link among oxidative stress, C reactive protein which is an inflammatory marker and the cardiovascular lipid risk factors in hypothyroid patients which has not been analyzed before. Sixty seven untreated hypothyroid patients were recruited consecutively for the study. Their ultrasensitive C reactive protein level and oxidative stress profile were measured apart from various lipid risk factors of cardiovascular disease. Ultra sensitive C reactive protein was significantly correlated with increased lipid risk factors of cardiovascular disease, thyroid stimulating hormone level and indices of oxidative stress in these patients. Low grade inflammation in hypothyroidism plausibly acts as the link between higher oxidative stress and the underlying cardiovascular risk among hypothyroid patients.