ABSTRACT
Unkei-to was used successfully to treat three patients with primary Sjögren's syndrome (pSjS). The first case was a 67-year-old woman. In April 1993, she visited Tonami General Hospital with the symptom of dry eyes. Her condition was diagnosed as pSjS from being antinuclear antibody (ANA) positive, dry eye, and decrease of saliva secretion. She used eye drops, but her dry eye did not improve, she visited our department in June 1995. Administration of Unkei-to improved her symptoms after 6 months of treatment.<br>The second case was a 73-year-old woman. In 1987, she was treated in our hospital for lumbago based on spondylosis. In 1991, she began to suffer from pain and swelling of the right sterno-clavicular joint (RSCJ) and was admitted. She was anti-SS-A/Ro ANA positive, schirmer's test was positive, lymphocyte infiltration was observed by lip biopsy, and thus pSjS was diagnosed. Treatment with Unkei-to resulted in the improvement of pain and swelling of RSCJ, as well as a decrease in serum C-reactive protein. But a favorable effect on dry mouth was not attained in this case.<br>The third case involved a 39-year-old woman who began to experience polyarthralgia and dry mouth in June 1991. She visited a neighborhood hospital and was diagnosed as pSjS from hyper γ-globulinemia, anti SS-A ANA positivity, and decrease of saliva secretion. She first visited our hospital in March 1994. We administered Keishikaryojutubu-to and improvement of polyarthralgia was observed. Subsequently, she suffered from symptoms of dry eye and dry mouth. We treated her with Unkei-to, which improved the symptoms of dryness, but not polyarthralgia in this case.<br>These observations suggest that Unkei-to might be a useful agent for the treatment of pSjS.
ABSTRACT
A 26-year-old woman visited our hospital complaining of infertility. Initially treatment was given based on clomiphene for induction of ovulation. However, she suffered from ovarian hyperstimulation syndrome (OHSS) due to the clomiphene, accompanied by abdominal pain. Unkei-to was decided on as the best mode of treatment since clomiphene could not be continued. The patient's basal body temperature (BBT) returned to its biphasic cycle. Three months later, natural pregnancy occurred that resulted in the birth of a healthy boy by normal delivery.<br>Unkei-to is frequently given for a variety of gynecological disorders, such as irregular menstruation, dysmenorrhea, discharge, climacteric disturbance, etc.<br>Although induction of ovulation is often a necessary and effective infertility therapy, multiple pregnancies and OHSS can be problematic. The present case suggests that Unkei-to may be effective for infertility involving clomiphene-induced OHSS