ABSTRACT
Objective To investigate the prevalence of human papillomavirus(HPV)infections in women with uterine cervical cancer in Wenzhou.Methods Exfoliated cells samples of cervix uteri were collected from 198 patients with cervical cancer. Flow-through hybridization technique was used to detect HPV and its genotypes.The relationship of HPV infection with cervical cancer stage,histological type and differentiation degree were analyzed.The prevalence of HPV infections in patients with different cervical diseases was observed.SPSS 13.0 was used for statistical analysis.Results In 198 patients with cervical cancer,HPV infection was occunrred in 147 (74.24%), of whom 101patients were superinfected (51.01%),and 129 patients(65.15%)were infected with the high-risk HPVs,which were significantly higher than those in cervicitis and cervical dysplasia(x2 = 28.28,65.34 and 95.22,P ＜ 0.01).HPV positive rate was not correlated with clinical stages,differentiation degree of cervical cancer(x2 = 0.475 and 0.969,P＞0.05).HPV positive rates in squamous cancer and adenocarcinoma had no statistical difference (x2 =0.582,P＞0.05).The logistic regression analysis showed that HPV 16/58 infection and age over 40might increase the risk of carcinogenesis of the cervix.Conclusion sHPV infection and superinfection are popular in women with cervix cancer in Wenzhou.HPV16/58 infection and age over 40 years are the risk factors of cervical cancer.
ABSTRACT
Objetivo: Presentar los efectos psicológicos y sociales que tuvieron las mujeres, residentes en Bogotá, sometidas a la prueba de ADN del VPH, y la manera como los médicos comunican los riesgos a sus pacientes. Métodos: Estudio cualitativo fenomenológico. Se realizaron 10 entrevistas semiestructuradas con mujeres que se practicaron la prueba ADN-VPH. Así mismo, se hicieron dos grupos focales: uno con médicos generales y otro con ginecólogos. Finalmente se hizo un análisis de contenido. Resultados: El impacto psicosocial se ha clasificado en tres categorías: en la esfera emocional, en la vida sexual y de pareja y en el comportamiento. Se diseñó un modelo de los determinantes de la magnitud de los efectos. Este modelo está determinado por la forma y el contenido de la información que suministra el médico y por las características biográficas de la mujer. Los efectos encontrados fueron ansiedad, rabia, vergüenza, culpa, zozobra por la demora de los resultados, miedo al cáncer y temor a tener relaciones sexuales. Conclusiones: La razón para practicar la prueba no debe ser promovida por el miedo al cáncer, sino por las características de la infección y la convicción sobre los beneficios de la prueba. Se debe promover una reflexión anticipada de la trayectoria de riesgos que se pueden presentar en el futuro utilizando como técnica de comunicación la toma de decisiones de manera concertada.
Objective: To present the psychological and social effects of DNA and HPV exams among women resident in Bogotá; and, the means by which physicians communicate risks to patients. Ten, semi-structured interviews were carried out among women who underwent HPV-DNA examination. Simultaneously, two focus groups were set up: one with general practitioners and the other with gynecologists. Content analysis took place. Methods: Qualitative study with a phenomenological perspective. Ten semi-structured interviews were conducted with women who underwent HPV testing. Two focus groups were carried out with gynecologists and medical practitioners. A content analysis was performed. Results: Psychosocial impact has been classified into three categories: emotional; sex life and partner relationship; and, behavior. A model was designed to measure the magnitude of the effects of these determinants. This model is based upon the form and content of the information provided by physicians and by women´s biographical data. The effects encountered included: anxiety, rage, shame, guilt, panic at delayed results, fear of cancer, and fear of sexual relations. Conclusions: The reasoning to undergo examination should not be based upon fear, but rather on knowledge of infection symptoms and the conviction that the examination is beneficial. Thinking about risk trajectories should play a relevant part in the communication process based on the concept of concerted decision-making.