Significance of Gray-Level Histogram of the Uterine Cervix as a Predictor of Preterm Birth in Pregnant Women with Preterm Labor / 대한주산의학회잡지

PURPOSE: The aim of this study was to determine the value of a gray-level histogram of the cervix as a predictor of preterm birth in women who admitted for preterm labor. METHODS: Ninety-seven women who admitted Chonnam national university for preterm labor were enrolled in this prospective study. A transvaginal ultrasonography for measurement of cervical length (CL), gray-scale histogram and cervical volume was performed when patients were admitted. Anterior and posterior cervical walls and AP (anterior and posterior) difference in MGL (mean gray level between anterior and posterior) were checked. And we analyzed the relationship between the value and preterm birth. RESULTS: The overall rate of preterm birth before 37 weeks was 53.6% and after 37 weeks was 46.4%, respectively. Logistic regression analysis demonstrated that not only cervix length (P=0.003; odds ratio [OR], 0.189; 95% confidence interval [CI], 0.064-0.560) but also anterior histogram (P=0.028; OR, 0.319; 95% CI, 0.115-0.884) was independent predictor of preterm birth before 37 weeks. The receiver operator characteristics (ROC) curves were analyzed for the anterior histogram, a value of 85.9 was the best cut-off value to determine the preterm birth. The areas under the ROC curve indicate that the variable provides a prognostic value for the prediction for preterm birth. To predict a preterm birth, anterior histogram had 78.8% sensitivity and 46.7% specificity. CONCLUSION: Gray-level histogram of the uterine cervix may predict the preterm birth in pregnant women with preterm labor.

Monitoreo del borrado del cuello uterino con sonografía transperineal: posible significancia pronóstica / Monitoring of cervical shortening with transperineal sonography: possible prognostic significance

Monitorear los cambios en la longitud, ancho y forma del cuello uterino, con sonografía transperineal en las seis últimas semanas del embarazo y su posible significancia pronóstica. En 97 embarazadas normales atendidas en consulta prenatal de rutina, a las 34-40 semanas de gestación, se practicaron 173 mediciones de la longitud y ancho del cuello uterino, mediante sonografía transperineal. Grupo Médico Nova Cecil, La Trinidad. De las 97 embarazadas 82 parieron normalmente y 15 fueron intervenidas por estrechez pélvica. En los partos normales, en el promedio, por el aumento del ancho del cuello en 1 mm, la longitud del cuello decreció 0,37 mm en el rango de mediciones realizadas. Además, la pendiente fue significativamente diferente de cero. Por el contrario, en las intervenidas estos cambios no presentaron significancia estadística. Mientras la correlación entre largo y ancho del cuello fue estadísticamente significativa en las pacientes con parto normal, no ocurrió así en las pacientes intervenidas. Estos cambios tienen significancia pronóstica

To monitor uterine cervix’ length, wide and form with transperineal sonography in the last six weeks of pregnancy and their prognostic significance. In 97 normal pregnant women attending routine antenatal care at 34-40 gestational weeks, we performed 173 measurements of the length and wide of the cervix, by transperineal sonography. Grupo Médico Nova Cecil, La Trinidad. Out of the 97 pregnant women 82 delivered vaginally and 15 were operated due to pelvic stenosis. In the normal deliveries, on the average, for every increase in the cervix width of 1 mm, the cervix length decreases 0,37 over the range of measurements made. Besides, the slope was statistically significant from zero. On the contrary, in the caesarean cases these changes did not were statistically significant. While correlation between length and wide was statistically significant in normal deliveries, this relationship was absent in the caesarean cases. These changes have prognostic significance

Parto pretérmino: valor predictivo del estriol salival, vaginosis bacteriana y longitud cervical / Preterm delivery: predictive value of salivary estriol, bacterial vaginosis and cervical length

Evaluar las concentraciones de estriol salival, presencia de vaginosis bacteriana y longitud cervical como predictores del parto pretérmino, en pacientes asintomáticas. Estudio descriptivo, prospectivo, comparativo, en embarazadas divididas en dos grupos. El grupo estudio con riesgo (A) y el grupo control (B). Consulta prenatal del Hospital General del Oeste "Dr. José Gregorio Hernández". De las 60 pacientes evaluadas, 5 (8,33 por ciento) presentaron parto pretérmino, de las cuales 4 (80 por ciento) eran del grupo estudio y 1 (20 por ciento) del grupo control. Este último fue inducido por indicaciones médicas. Hubo 3 casos (5,0 por ciento) de amenazas de parto pretérmino pertenecientes al grupo estudio. En las pacientes con parto pretérmino la longitud del cuello uterino entre las 16 y 18 semanas de gestación osciló entre 30 y 445,6 mm con un promedio de 38,05 ± 6,38 mm. Entre las 24 y 28 semanas los valores fueron entre 24 y 25 mm con un promedio de 24,78 ± 0,68 mm. En las pacientes con parto pretérmino la vaginosis bacteriana entre las 16 y 18 semanas se presentó en 3 pacientes; entre las 24 y 28 semanas todas las pacientes tuvieron resultados positivos. Las concentraciones de estriol libre en saliva en las pacientes con parto pretérmino a las 22 semanas osciló entre 0,3 y 3,5 ng/mL con un promedio de 1,55 ± 1,45 ng/mL. A las 29 semanas de 0,8 y 3,7 ng/mL, promedio 1,73 ± 1,0 y a las 36 semanas de 2,3 y 3,2 ng/mL promedio 0,85 ± 1,10 ng/mL . El acortamiento del cuello uterino (menor o igual a 25 mm) determinado a través de ecosonograma transvaginal entre las 24 y 28 semanas, está asociado de manera significante a parto pretérmino en pacientes asintomáticas con alto riesgo. En contraste, el aumento de estriol libre en saliva no está asociado de manera significante con parto pretérmino en estas pacientes. La vaginosis bacteriana se observó con mayor frecuencia en pacientes con riesgo. En contraste, el aumento de estirol libre en saliva no está asociado de...

To evaluate the salivary estriol concentration, presence of bacterial vaginosis and cervical length as predictors of preterm labor in asymptomatic patients. Descriptive, prospective and comparative study, in pregnant patients divided into two groups. The study group (A) and the control group (B). Outpatient prenatal clinic at the "Hospital General del Oeste "Dr. Jose Gregorio Hernandez". From 60 patients evaluated, 5 (8.33 percent) had preterm delivery, 4 (80 percent) belong to the group A and 1 (20 percent) to the group B. The last one was induced by medical reasons. There were 3 cases (5.0 percent) of threatening of preterm delivery from the group A. In the patients with preterm delivery the length of the uterine cervix between 16 to 18 weeks of gestation ranged from 30 to 45.6 mm with mean of 38.05 ± 6.38 mm. Between the 24 and 28 weeks the values were between 24 and 25 mm with mean of 24.78 ± 0.68 mm. In the patients with preterm delivery the bacterial vaginosis between 16 and 18 weeks was present in 3 patients; between 24 and 28 weeks all patients had positive results. The concentrations of free estradiol in saliva in patients with preterm delivery ranged from 0.3 to 3.5 ng/mL, with a mean of 1,55 ± 1,45 ng/mL. At 29 weeks from 0.8 to 3.7 ng/mL, mean 1.73 ± 1.0 and at 36 weeks from 2.3 and 3.2 ng/mL with mean of 0.85 ± 1.10 ng/mL. The shortening of uterine cervix (lower or equal to 25 mm) determined by transvaginal ultrasound between 24 and 28 weeks, is significatly associated to preterm delivery in asymptomatic patients with high risk. On the other hand, the increase of free estriol in saliva is not significantly associated to preterm delivery in these patients. Bacterial vaginosis was observed more frequently in patients with high risk of preterm delivery