ABSTRACT
A doença metastática que envolve o útero é rara. Geralmente os ovários são o órgão envolvido e o tumor primário é habitualmente da mama ou do trato gastrointestinal.Caso clínico: Os autores apresentam um caso de metastização uterina de carcinoma mamário. A doente tinha antecedentes de mastectomia bilateral por carcinoma invasivo NOS havia mais de 30 anos. A avaliação histológica do produto de biópsia histeroscópica, complementada com imuno-histoquímica, confirmou a origem do tumor primário como mamário e de variante lobular. A doente recusou outros procedimentos invasivos, mas concordou com seguimento clínico e ecográfico. Conclusão: Geralmente a doença metastática da mama para o trato genital feminino deve-se majoritariamente a carcinoma lobular invasivo. Apresentamos um caso de metastização uterina de carcinoma lobular invasivo, mais de 30 anos após o tumor primário, o qual foi classificado como carcinoma invasivo NOS e confirmado em revisão de lâminas. É de salientara importância de uma correta informação clínica ao patologista do antecedente oncológico, de forma a poder ser feito um correto diagnóstico diferencial.
Metastatic disease involving the uterus is rare. Typically it is the ovaries that are involved and the primary tumor is usually the breast or the gastrointestinal tract. Case report: We describe a case of metastatic breast carcinoma involving the uterus in a patient who had had a bilateral mastectomy due to invasive carcinoma NOS more than thirty years ago. Histological assessment of the hysteroscopy biopsy specimen including immunohistochemistry staining confirmed the breast carcinoma as the primary lesion, however it was classified as lobular carcinoma. The patient refused surgery or other invasive procedures, having complied nevertheless to follow up with clinical and ultrasound evaluation. Conclusion: Metastatic breast disease to the feminine genital tract is more frequently due to lobular invasive carcinoma. We present a case of uterine metastization of invasive lobular carcinoma more than thirty years since the primary tumor, which was classified as invasive carcinoma NOS and confirmed by histological revision. It is of great importance to give the pathologist the correct information about the patient, namely of any oncologic background, so differential diagnosis can be made.
Subject(s)
Humans , Female , Adult , Cadherins , Neoplasm Metastasis , Breast Neoplasms/complications , Uterine NeoplasmsABSTRACT
Metastatic extragenital cancer that spreads to the uterus is rare. When it occurs, the extragenital primary disease is often in the breast or gastrointestinal tract. We report here on a case of hepatocellular carcinoma (HCC) that metastasis to the uterus. The patient was admitted for evaluation of a pelvic mass. The serum alpha-fetoprotein level was highly elevated. Magnetic resonance imaging of the abdomen and pelvis showed hepatic and uterine masses. The patient underwent surgical treatment. The histopathologic findings and immunohistochemical staining results of the uterine mass were characteristics of metastatic HCC. The endometrium and both ovaries were free of tumor. Up to now, there have been only two cases of uterine metastasis from HCC reported in the English literature. This case is the first documented instance of a metastatic uterine tumor from HCC that spared both ovaries.