ABSTRACT
OBJECTIVE:To study the postoperative use of anti-infectives inpatients undergoing liver transplantation and its rationality.METHODS:50 inpatients who had undergone liver transplantation were randomly collected from center of organ transplantation for the analysis of the use of anti-infective agents within 1 month after operation in respect of utilization frequency(cases/times),duration of medication,drug utilization index(DUI) as well the conformity between drug combination and etiology so as to derive the rationality of drug use.RESULTS:Among the top 10 anti-infectives in terms of utilization frequency in patients undergone liver transplantation,9 had their DUI less than 1,and 1 had its DUI above 1.The perioperative application rate of anti-infective agents was 100%.In terms of drug combination,2 cases(4%) used one kind of anti-infectives,17(34%) two kinds,21(42%) tree kinds,10(20%) four kinds concomitantly.CONCLUSION:The doses and the proportion of anti-infectives used in combination for inpatients undergoing liver transplantation were on the high side,which should be controlled urgently.
ABSTRACT
OBJECTIVE:To investigate the utilization of antipsychotic drugs in hospitalized patients of our hospital to provide reference for rational use of drug. METHODS: The utilization of antipsychotic drugs in psychiatric inpatients in our hospital in Jul. 21th of 2008 was surveyed and analyzed. RESULTS: 734 patients were treated with antipsychotic drugs, involving 30 drug therapy schemes. 676 patients were only treated with one kind of drug (87.8%),among which the top 3 drugs in the list of utilization rate were risperidone (n=190, 24.7%), quetiapine (n=144, 18.7%) and olanzapine (n=123, 16.0%). Antipsychotic drugs were mostly combined with following drugs for mental disorder, such as antidepressant, mood stabilizers, benzodiazepine, sedative-hypnotic drugs, hypoglycemics and lipid regulators. CONCLUSION:The new atypical antipsychotic drugs have replaced traditional antipsychotic drugs and took up dominant position in the clinical treatment with single category.