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Introduction: Cancer is the second most common disease in India responsible for maximum mortality with about 0.3 million deaths per year. This is owing to the poor availability of prevention, diagnosis and treatment of the disease. Almost 9 out of 10 deaths occur from cervical cancer in less developed countries. Cancer of the cervix is largely preventable. The risk can be minimized by promotion of sexual risk reduction behavior and genital hygiene. Further prevention can be achieved by screening, using Visual Inspection with Acidic Acid (VIA) or Pap smear test, which can detect precancerous lesions early so as to prevent progress towards invasive cancer by timely treatment. Materials and Methods: A pre-experimental, One-group pre-test post-test design was undertaken for the study. 300 women were selected as the sample, Non- probability convenient sampling technique was utilized to select the sample from the population. After assessing knowledge video assisted teaching was implemented. After intervention on 7th day the post-test knowledge was assessed. Chi-square was used to measure the association of background variables of patients. ‘t’ test was used to assess the effectiveness of structured interventional programme of the patients. In the comparison between mean pretest and posttest knowledge score it is clear that during the pretest the knowledge score was poor (40%), fair ( 10%), good ( 40%) and excellent ( 10%), and after the administration of video assisted teaching, posttest was done and there was an improvement in the knowledge score of the female by poor (0%), fair (16.7%), good (23.3%) and excellent was( 60%), so there was a great difference in the knowledge score between the pre-test and posttest. Result: The mean pretest knowledge score was 13.67 ± 7.66, while the posttest knowledge score was 23.80 ± 5.53 and the computed t value was found to be 19.105, The difference was found to be statistically significant. There will be significant association between the pretest knowledge score and selected demographic variables at the level of P? 0.05. is accepted as there is significant association between pretest knowledge score and selected demographic variables like religion, marital status, Age of women at marriage, no. of times they have conceived, methods of contraception’s, educational status, occupation, kinds of addiction, recurrent infections, history of cancer in family, previous information regarding cancer, history of pap test. Conclusion: The study recommended the utilization of video assisted teaching programme by community health nurses, nurse researchers, nurse administrators, nurse educators and health care professionals to improve knowledge of early detection of cervical cancer.
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The objective of this research work is related to the fact that the source of isolation and acclimatization process influences the microorganism’s potential for the decolorization of various substances. Some of the widely used anthraquinone vat dyes decolorization by the pure bacterial strain is a significant aspect that will assist in the in-situ bioremediation of the ecosystem.The present study is to evaluate the enhanced decolorization of Vat Brown R by an isolated bacterium, Pseudomonas aeruginosa NCH, from textile dye wastewater under aerobic conditions. The effect of pH, temperature, and inoculum size was optimized using response surface methodology with the box-behnken experimental design. The strain NCH showed maximum decolorization efficacy under optimum conditions at pH9.76, temperature 34.69?C, and an inoculum size of 9.51% (v/v), respectively. A decolorization of 90.34% was observed with 100 mg L?1of Vat Brown R within 18h under these conditions. Confirmatory experiments have verified the optimum combination of the three variables predicted by RSM. Kinetics study was carried out using various approaches: Michaelis-Menten (Vmax = 29.1 mg L?1 h?1 and Km = 25.2 mg L?1), Lineweaver-Burk (Vmax = 30.12 mg L?1 h?1 and Km = 26.91 mg L?1), and Eadie-hofstee model (Vmax = 30.23 mg L?1h?1and Km = 27.29 mg L?1), and the results showed that the degradation followed a first-order reaction kinetics. The subsequent degradation of the dye and the formation of metabolites were studied using analytical techniques such as UV-vis spectroscopy and FT-IR analysis. UV-vis spectroscopy validated the detoxification of the dye and confirmed that Pseudomonas sp. NCH overcomes this decolorizing activity through biodegradation. This study investigated the highest decolorization efficiency of strain NCHused in the biodegradation of wastewaters containing anthraquinone dyes.
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Background: The relationship between thyroid function, body weight and central obesity in euthyroid individuals has been given a great medical concern. Central abdominal adiposity can be divided into adipose tissue present in subcutaneous areas (SCAT) and visceral areas (VAT). The type of adiposity may be implicated in the associations of thyroid function parameters with obesity. The aim of the present study was to evaluate thyroid function and its possible relationship with BMI, body fat percent, waist circumference, SCAT and VAT in eu-thyroid female subjects.Methods: Randomly selected eu-thyroid female subjects were included in this study. Their BMI was estimated by metric method, body fat percent was measured by Harpenden skin fold caliper. Ultrasound (US) was used to assess regional adiposity. Serum TSH was measured from fasting serum sample by Enzyme-linked-immuno-sorbant (ELISA) Assay. Data was analysed by SPSS (version 18).Results: A positive linear association was found between serum TSH level and BMI, body fat percent, waist circumference and VAT. (r=0.342, p <0.002, r=0.628, p <0.00, r=0.289, p <0.009, r=0.375, p <0.000). No significant association was found with SCAT and TSH. There is gradual increase in serum TSH values among three BMI groups i.e. normal weight (BMI <23 kg/m2), over-weight (BMI 23.00-24.99 kg/m2), and obese (BMI >25 kg/m2) females. Body fat percentage, BMI and VAT were found to be significant independent predictors of TSH.Conclusions: Selective reduction of visceral fat may induce greater beneficial effects on the parameters of thyroid hormones than subcutaneous fat reduction.
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As a major part of China's deepening reform of fiscal and taxation system,"Business Tax to VAT" reflects the reform requirement of the top-level design.The paper takes a provincial hospital as an example and analyzes the influence of "Business Tax to VAT" on the operation of public hospitals in China.The reform allows hospitals and individuals to reduce expenses and helps improve medical service-providing system,but specifically,it also brings challenges and difficulties to the work of financial accounting,scientific research,the integrated management and so on in the public hospitals.To solve these problems,the paper puts forward several countermeasures,which indicates that public hospitals should improve accounting,enhance taxing management,give enough concern,develop information-sharing system while training personnel,and make a close link to the government.
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Aim of this article is to provide an overview of modifiable and nonmodifiable factor in the development of Nosocomial Infections (NIs) in the Neonatal Intensive Care Units (NICUs).Endotracheal tube intubation/Mechanical ventilation is a lifesaving invasive procedure which is associated with their own potential complications, like ventilator associated pneumonia (VAP), sepsis, Ventilator associated-tracheo-bronchitis(VAT), acute respiratory distress syndrome, pulmonary embolism, Barotrauma and pulmonary edema, which can occur among the patients receiving mechanical ventilation. Among the above listed complication, Neonatal sepsis is the most common and VAP is the second most common encountered Nosocomial infection, which account for the most of the morbidity and mortality in the NICUs and ventilated patients. PubMed, Embase and google scholar have been searched for the articles meeting our criteria,total fourteen articles have been used. Neither any alterations or modifications nor any Software’s were used in this article. In some recent research article and literature, some strategy have been mentioned, which are resulting in better control of Nosocomial infection due to ventilator or endotracheal tube intubation. Gram-negative bacteria are most prevalent in the developing countries and Gram-positive in the developed countries, Klebsiella pneumonia, E. coli and staphylococcus aureus are the most common reason for NIs. Increasing number of NIs and multidrug resistance bacteria are matter of concern for Neonatologist around the world.
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[Summary] The increasing prevalence of obesity has led to extensive research on white adipose tissue. Currently ,functional differences among white adipose tissue depots have become clear ,especially between visceral adipose tissue (VAT ) and subcutaneous adipose tissue (SAT ). This article will review the heterogeneity of distribution ,structure ,function ,influence factors ,measurement methods and metabolic properties between VAT and SAT.
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Ischemic brain injury is a major disease which threatens human health and safety. (3, 5, 6-trimethylpyrazin-2-yl) methyl 3-methoxy-4-[(3, 5, 6-trimethylpyrazin-2-yl) methoxy] benzoate (VA-T), a newly discovered lead compound, is effective for the treatment of ischemic brain injury and its sequelae. But the poor solubility of VA-T leads to poor dissolution and limited clinical application. In order to improve the dissolution of VA-T, the pharmaceutical technology of solid dispersions was used in the present study. VA-T/polyvinylpyrrolidone (PVP) solid dispersion was prepared by the solvent method. The dissolution studies were carried out and solid state characterization was evaluated by differential scanning calorimetry (DSC), infrared spectroscopy (IR), x-ray diffraction (XRD) and scanning electron microscopy (SEM). The dissolution rate of VA-T was significantly improved by solid dispersion compared to that of the pure drug and physical mixture. The results of DSC and XRD indicated that the VA-T solid dispersion was amorphous. The IR spectra showed the possible interaction between VA-T and PVP was the formulation of hydrogen bonding. The SEM analysis demonstrated that there was no VA-T crystal observed in the solid dispersions. The ideal drug-to-PVP ratio was 1:5. In conclusion, the solid dispersion technique can be successfully used for the improvement of the dissolution profile of VA-T.
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Benzoates , Chemistry , Brain Ischemia , Drug Therapy , Chemistry, Pharmaceutical , Methods , Drug Delivery Systems , Povidone , Chemistry , SolubilityABSTRACT
Quantities as well as distributions of adipose tissue (AT) are significantly related to cardiovascular disease (CVD) risk factors and can be altered with caloric restriction. This study investigated which cross-sectional slice location of AT is most strongly correlated with changes in CVD risk factors after caloric restriction in obese Korean women. Thirty-three obese pre-menopausal Korean women (32.4 +/- 8.5 yrs, BMI 27.1 +/- 2.3 kg/m2) participated in a 12 weeks caloric restriction program. Subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were measured using computed tomography (CT) scans at the sites of L2-L3, L3-L4, and L4-L5. Fasting serum levels of glucose, insulin, triglyceride, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), leptin and homeostasis model assessment-insulin resistance (HOMA-IR) were observed. Pearson's partial correlation coefficients were used to assess the relationship between AT measurement sites and changes in CVD risk factors after calorie restriction. When calories were reduced by 350 kcal/day for 12 weeks, body weight (-2.7%), body fat mass (-8.2%), and waist circumference (-5.8%) all decreased (P < 0.05). In addition, following caloric restriction, serum levels of glucose (-4.6%), TC (-6.2%), LDL-C (-5.3%), leptin (-17.6%) and HOMA-IR (-18.2%) decreased significantly (P < 0.05) as well. Changes in VAT at the level of L3-L4 were significantly greater than those at other abdominal sites, and these changes were correlated with changes in TC (P < 0.05), LDL-C (P < 0.001), SBP (P < 0.001) and HOMA-IR (P < 0.01). These results show that VAT at L3-L4 had a stronger correlation with CVD risk factors than with other AT measurement sites after caloric restriction.
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Female , Humans , Adipose Tissue , Body Weight , Caloric Restriction , Cardiovascular Diseases , Cholesterol , Cholesterol, HDL , Cholesterol, LDL , Fasting , Glucose , Homeostasis , Insulin , Intra-Abdominal Fat , Leptin , Lipoproteins , Risk Factors , Subcutaneous Fat , Waist CircumferenceABSTRACT
Se destaca al sobrepeso y obesidad como el principal condicionante actual de patología crónica no transmisible. Se identifican y discuten las principales comorbilidades asociadas al sobrepeso y obesidad, analizando las evidencias que las apoyan. Se destaca el rol de la adiposidad en la etiopatogenia del síndrome metabólico y en forma muy especial de la DM. Se analiza la asociación entre indicadores de masa corporal y tejido adiposo y tasas de mortalidad, destacando un significativo incremento de la mortalidad a medida que la masa corporal o grasa se incrementa. Se destacan los rangos asociados a la menor mortalidad, nadires que fundamentan los rangos de peso normal. Se discute en forma separada la asociación entre sobrepeso yobesidad en la infancia y adolescencia y salud, en especial su posible rol en la incidencia de patologías crónicas al alcanzar la adultez.
The article highlights overweight and obesity as the main factor in some current chronic diseases. Also it identifies and discusses major co-morbidities associated with overweight and obesity, analyzing the evidence that support them. The role of adiposity in the pathogenesis of metabolic syndrome especially in the development of mellitus diabetes 2 is discussed. We analyze the association between indicators of body mass and adipose tissue and mortality, highlighting a significant increase in mortality as the fat body mass increases and shows the range associated with lower mortality, basing the normal weight ranges. Will be discussing separately the association between overweight and obesity in childhood and adolescence health, especially its possible role in the incidence of chronic diseases that will develop at adulthood.
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Humans , Adipose Tissue , Adipocytes/physiology , Overweight , Obesity/epidemiology , Comorbidity , Metabolic Diseases , Risk FactorsABSTRACT
Objective To find new methods to control the pollution of dye,the law of adsorption and adsorption kinetics of vat blue RSN by amidoxime fiber were studied. Methods The amidoxime-Fe(Ⅲ) adsorption fiber was made from PAN fiber containing amidoxime groups reaction with Fe3+. The adsorption of vat blue in the aqueous solution on the amidoxime-Fe(Ⅲ) adsorption fiber was studied. The reaction order was determined by infinitesimal calculus,based on the relationship between the adsorption time and the concentration of vat blue. The activation energy was obtained by the rate constant of different temperature and the Arrhenius equation. Results The results of adsorption showed the optimal condition:pH was 10.5,the temperature was 45 ℃ and adsorption time was 80 min. The absorption was accorded with the Freundlich isotherm and the character of the first-order reaction. Conclusion The process of vat blue RSN adsorption by amidoxime fiber is simple and the raw materials of amidoxime fiber is very cheap,so it may be expected to apply to the industrial wastewater treatment
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The remedy "Tu vat dao hong" is made up and manufactured at Pharmacy in Army Traditional Medical Institute. The experiment is conducted on healthy rabbits after coagulating endovascular scattered blood in 3 groups (treated group, controlled group, tanakan group). Results: Howell time in all groups were shorted, rabbits died at second week in controlled group; Quick time were also shorted, and rabbits died also at second week; APTT time reduced significantly (p<0.05) when compared with previous experiment. Platelet quantify, fibrinogen quantify, ethanol test were limited. The remedy have good relative effects when compared tanakan standard drug used in same condition
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Drug Prescriptions , Pharmacy , Medicine, TraditionalABSTRACT
OBJECTIVE:To provide the pharmacoeconomics referance for the medical reform implementation in China.METHODS:The relevant literatures at home and abroad combined with knowledge of pharmacoeconomics were to introduce and analyze the experience of pharmacoeconomics application at home and abroad.RESULTS & CONCLUSION:The pharmacoeconomics is involved in various related areas of drugs,and provides a scientific basis for drug pricing,reimbursement and other links.China should be based on international experience,combined with its national conditions to promote the development of pharmacoeconomics in order to effectively control the unreasonable increase in drug expenses,so that people really can "control it,use it,and afford it".