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Objective To observe the clinical curative effect of Gong Yanping capsule combined with recombinant human interferon α2b vaginal effervescent tablets in the treatment of human papillomavirus infection.Methods80 cases of patients with cervical HPV infection in Xiangshan hospital of traditional Chinese medicine from May 2014 to May 2016 were selected, these patients were divided into Gong Yanping capsule combined with interferon treatment group (combined treatment group, 40cases) and pure Gongyanping capsule treatment group (single treatment group, 40cases) two groups according to the treatment methods, the clinical curative effects, HPV-DNA levels, HPV infection status, incidences of adverse reactions of the two groups were statistically analyzed.ResultsThe clinical total efficiency of the combined treatment group 95% (38/40) was significantly higher than the single treatment group 80% (32/40) (P<0.05), the HPV-DNA level was significantly lower (P<0.05), the HPV infection negative rate 1 months after treatment 2.5% (1/40) was significantly lower than the single treatment group 10% (4/40) (P<0.05), the negative rates 2 months, 3 months after treatment 67.5% (27/40), 97.5% (39/40) were significantly higher than the single treatment group 40% (16/40), 77.5% (31/40) (P<0.05);The difference of incidences of adverse reactions between the two groups 12.5% (5/40), 7.5% (3/40) was not significant.ConclusionThe clinical curative effect of Gong Yanping capsule combined with Recombinant Human Interferon α2b Vaginal Effervescent Tablets in the treatment of human papillomavirus infection is more significant than pure Gongyanping capsule treatment, it will not increase the adverse reactions of patients in a great extent, is safe and effective.
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Objective:To explore the efficacy of ciclopirox olamine vaginal suppositories combined with fluconazole in the treat-ment of vulvovaginal candidasis. Methods:Totally 74 cases of vulvovaginal candidasis( VVC)infection were randomly divided into two groups with 37 ones in each. The control group orally received fluconazole combined with terbinafine hydrochloride vaginal effervescent tablets,and the observation group orally received fluconazole combined with ciclopirox olamine vaginal suppositories. The recent(7 days)and long-term(1 and 3 months)clinical curative effects and the drug safety in the two groups were observed and compared. Re-sults:after the 7-day treatment,the total clinical effective rate of the two groups showed no significant difference(P>0. 05);after the 1-month follow-up,the recurrence rate of the two groups had no significant difference(P>0. 05);after the 3-month follow-up,the re-currence rate of the observation group(2. 7%)was significantly lower than that of the control group(22. 2%,P<0. 05). The two groups showed no serious adverse drug reactions. Conclusion:Fluconazole combined with ciclopirox olamine vaginal suppositories in the treatment of vulvovaginal candidasis exhibits promising curative effect and low recurrence rate without serious adverse reactions.
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0.05);the cure rates were 55.77%,36.54% and 88.46%,re-spectively;the recurrence rates were 11.54%,25.00% and 1.92%,respectively.CONCLUSION:Scheme A is the preferable one economically,however,taking all the factors into consideration,scheme C is the best one.
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OBJECTIVE:To put forward some suggestions for improving the testing method on foam volume specified in drug quality standard in China.METHODS:The current testing method of the foam volume in vaginal effervescent tablets specified in drug quality standard was analyzed systematically and comprehensively and compared in respect of the measuring tool,water volume added for foaming,system temperature and operation method,etc.RESULTS & CONCLUSIONS:The problems of the quality standard for the testing of foam volume manifested as nonstandard in operation and incomplete in contents,which were mainly caused by the lack of unified guidelines in setting quality standards for different categories.The drug manufacturers should attach great importance to all links that affect the drug quality and establish and perfect a guideline for the quality standard of the foam volume testing so as to further standardize the standard.