ABSTRACT
ABSTRACT Exogenous lipoid pneumonia (ELP) is an unusual disease, with an incidence of 1 to 2.5%, caused by aspiration and accumulation of exogenous lipids in the pulmonary alveoli. When the aspirated agent has an oily composition, a pulmonary inflammatory reaction called lipoid pneumonia is triggered, which over time can lead to irreversible parenchymal fibrosis. Sometimes it can appear as nodular lesions that require a broad differential diagnosis, in which case imaging studies have a fundamental role. Histopathological confirmation is required for definitive diagnosis1. We present a clinical case of lipoid pneumonia which appeared as a lung mass accompanied by bilateral pulmonary infiltrates.
RESUMEN La neumonía lipoidea exógena (NLE) es una patología inusual, que tiene una incidencia del 1% al 2,5%, y tiene su causa en la aspiración y la acumulación de lípidos de origen exógeno dentro de los alvéolos pulmonares. Cuando el agente aspirado es de composición oleosa, se desencadena una reacción inflamatoria pulmonar denominada neumonía lipoidea, que con el tiempo puede conducir a una fibrosis parenquimatosa irreversible. En ocasiones, se puede presentar en forma de lesiones nodulares, que obligan a un amplio diagnóstico diferencial, en el que desempeñan un papel fundamental los estudios por imágenes. Para el diagnóstico definitivo, se requiere confirmación histopatológica1. Presentamos un caso clínico de neumonía lipoidea que se presentó como masa pulmonar acompañada de infiltrados pulmonares bilaterales.
ABSTRACT
La neumonía lipoidea exógena (NLE) es una patología inusual, que tiene una incidencia del 1% al 2,5%, y tiene su causa en la aspiración y la acumulación de lípidos de origen exógeno dentro de los alvéolos pulmonares. Cuando el agente aspirado es de composición oleosa, se desencadena una reacción inflamatoria pulmonar denominada neumonía lipoidea, que con el tiempo puede conducir a una fibrosis parenquimatosa irreversible. En ocasiones, se puede presentar en forma de lesiones nodulares, que obligan a un amplio diagnóstico diferencial, en el que desempeñan un papel fundamental los estudios por imágenes. Para el diagnóstico definitivo, se requiere confirmación histopatológica1. Presentamos un caso clínico de neumonía lipoidea que se presentó como masa pulmonar acompañada de infiltrados pulmonares bilaterales.
Exogenous lipoid pneumonia (ELP) is an unusual disease, with an incidence of 1 to 2.5%, caused by aspiration and accumulation of exogenous lipids in the pulmonary alveoli. When the aspirated agent has an oily composition, a pulmonary inflammatory reaction called lipoid pneumonia is triggered, which over time can lead to irreversible parenchymal fibrosis. Sometimes it can appear as nodular lesions that require a broad differential diagnosis, in which case imaging studies have a fundamental role. Histo pathological confirmation is required for definitive diagnosis1. We present a clinical case of lipoid pneumonia which appeared as a lung mass ac companied by bilateral pulmonary infiltrates.
Subject(s)
Pulmonary FibrosisABSTRACT
Objectives: Compare the advantages of ventilated nasal packing with conventional Waseda's nasal packing. Research design: Randomized controlled trial. Materials and Methods: In this investigation, a sample size of 80 patients was calculated utilizing a WHO calculator. Patients were isolated into two gatherings utilizing the lottery strategy endotracheal tube and surgical gloves loaded with lace goose were utilized for the manufactured ventilated nasal packs and compared with traditional nasal packs. Nasal obstruction and sleep disturbances were learned at 8 and 24 hours postoperatively utilizing a visual analog scale. Results:Mean nasal obstruction by ventilated intranasal pack was 45.62 ± 6.17, Vaseline sinus pack was 77.67 ± 4.85, statistically significant (p = 0.001) in the two gatherings. The mean sleep disturbances in the two gatherings were 46.32 ± 5.23 and 68.75 ± 2.70, separately, and were statistically significant (p = 0.001) in the two gatherings. Conclusion:Patients with ventilated nasal packs were found to have great resistance to nasal packs because of less nasal obstruction and sleep disturbance.
ABSTRACT
Los trastornos deglutorios secundarios a diferentes patologías pueden desencadenar episodios aspirativos hacia la vía aérea, condicionando una injuria pulmonar cuya gravedad dependerá del material aspirado y del tiempo de exposición. Cuando el agente aspirado es de composición oleosa, su aspiración es capaz de desencadenar una reacción inflamatoria pulmonar denominada neumonía lipoidea, pudiendo con el tiempo conducir a una fibrosis parenquimatosa irreversible. En el caso presentado se describe un paciente con trastornos deglutorios e ingesta prolongada de vaselina como laxante. Revisten interés el extenso compromiso asimétrico del parénquima pulmonar y la metodología diagnóstica empleada para identificar los macrófagos pulmonares cargados con lípidos, realizándose una revisión de la evidencia al respecto en la discusión del caso.
Deglutitive disorders that result from different diseases may cause aspiration episodes into the airways, determining a lung injury whose severity will depend on the material that was aspirated and the exposure time. If the aspirated agent has an oily composition, its aspiration is capable of triggering a pulmonary inflammatory reaction called lipoid pneumonia which after some time may cause irreversible parenchymal fibrosis. The case reported in this study describes a patient with deglutitive disorders and prolonged intake of vaseline as laxative. The large assymetric involvement of the lung parenchyma and the diagnostic methodology used to identify lung macrophages charged with lipids take particular importance. A review of the evidence has been carried out in that regard during the discussion of the case.
ABSTRACT
Introduction: Recently, ointment bases have been considered to play more important roles in wound healing than those played by their main agents. There has been an increasing interest in the use of macrogol (MAC) because it is considered to accelerate the epithelialization of pressure ulcers. We compared the effectiveness of MAC and vaseline (VAS) in healing d2 (partial-thickness skin loss) sacral pressure ulcers.Methods: Twenty-five cases of d2 sacral pressure ulcers, which occurred in patients in long-term-care beds in our hospital, were initially included in this study. VAS was applied to d2 sacral pressure ulcers in 13 cases (VAS group), and MAC was also applied in 12 cases (MAC group). After VAS or MAC was applied, all pressure ulcers were covered with non-adhesive, water-absorbing gauzes. One case of in-hospital mortality was excluded from the MAC group; therefore, 13 cases in the VAS group and 11 cases in the MAC group were included in the final analysis. The healing periods were compared between the two groups.Results: There were no significant differences in the patients' background between the two groups. The healing period (days) in the MAC group (8 [7-11.5]) was significantly shorter than that in the VAS group (16 [12-32]) (P=0.029).Conclusion: MAC may accelerates the healing process of d2 sacral pressure ulcers.
ABSTRACT
Objective To establish a method to simultaneously determine syringing and isofraxidin by HPLC;To investigate the features of percutaneous absorption in vitro of Jiegugao blended and pasted by white vinegar, honey and vaseline; To discuss the mechanism of commonly used ointment matrices in Tujia Minority. Methods Rat abdomen skin in vitro was as transdermal barrier;the modified Franz diffusion pool was used to simulate human skin medication; the content of syringin and isoprofen was determined by HPLC; the percutaneous absorption equation was established and the related parameters, such as cumulative permeation rate and permeation rate, were calculated. Results When using Syncronis C18 (250 mm × 4.6 mm, 5 μm) as chromatographic column, acetonitrile-0.1%phosphoric acid as mobile phase, 1.0 mL/min as perfusion speed and 265 nm as determine wavelength, regression equation of syringingwas A=10 686.454 6C+1565.778 8 (r=1.000 0), regression equation of isofraxidin was A=12 297.305 4C-5913.729 9 (r=0.999 9). Cumulative permeation quantity of syringing in Jiegugao blended and pasted by white vinegar, honey, vaseline and blank were 7.549 2, 4.580 3, 3.890 8 and 5.378 4 μg?cm-2?h-1 respectively and permeation rate were 25.66%, 16.11%, 13.73% and 18.78%. Meanwhile, cumulative permeation quantity of isofraxidin were 2.536 9, 1.941 8, 1.178 2 and 2.293 6 μg?cm-2?h-1 respectively and permeation rate were 47.04%, 35.06%, 22.11%and 41.11%. Conclusion Using white vinegar as the ointment matrix can promote the percutaneous absorption of effective composition in Jiegugao blended. However, it will retard the percutaneous absorption of effective composition in Jiegugao when using honey and vaseline as the ointment matrices, but honey and vaseline can be used as a slow-release matrix.
ABSTRACT
Objective:To determine the phase-transition temperature of white vaseline produced by different processes by differen-tial scanning calorimetry ( DSC) in order to analyze the relevance between the melting point and the phase-transition temperature and the relevance between different production processes and the phase-transition temperature. Methods: Hermertic aluminum pans were used to encapsulate the samples, and the testing conditions were optimized. The sample weight was about 10 mg, and the range of measuring temperature was -20-100℃. The heating rate was 5℃·min-1 and the flow rate of nitrogen was 30 ml·min-1 . Results:The phase-transition temperature and the melting point were significantly different. The phase-transition temperature of white vaseline samples produced by different processes was quite different. Conclusion:Melting point determination in the current standard method of white vaseline exists defects, and the composition of white vaseline produced by various processes is quite different.
ABSTRACT
Objective To adjust the prescription of urea ointment and investigate its stability .Methods In accordance with the original prescription , four groups of urea ointment were prepared .Group A and group B were made with yellow vaseline from different manufacturers , while groups C and D were prepared in summer and winter respectively with the same source materials.The viscosity and moldability of the four groups were evaluated through the senses .The prescription was slightly adjusted through the single-factor effect experiment .Three batches of urea ointment were prepared according to the new prescription and their stability was investigated .Results Using the original prescription , the urea ointment made with yellow vaseline provided by Manufacturer One had better viscosity and moldability than that from Manufacturer Two .The urea ointment made in summer had lower viscosity and poorer moldability than the one made in winter .The amount of beeswax increased in the adjusted prescription .Three batches of urea ointment were prepared with the new prescription and their stability was maintained .There were no changes in appearance , and the content and microbial limit remained in the standard range for 11 months.Conclusion The source of materials and change of the external environment could affect the characteristics of urea ointment .The adjusted prescription is feasible and stable .
ABSTRACT
Objective To adjust the prescription of urea ointment and investigate its stability .Methods In accordance with the original prescription , four groups of urea ointment were prepared .Group A and group B were made with yellow vaseline from different manufacturers , while groups C and D were prepared in summer and winter respectively with the same source materials.The viscosity and moldability of the four groups were evaluated through the senses .The prescription was slightly adjusted through the single-factor effect experiment .Three batches of urea ointment were prepared according to the new prescription and their stability was investigated .Results Using the original prescription , the urea ointment made with yellow vaseline provided by Manufacturer One had better viscosity and moldability than that from Manufacturer Two .The urea ointment made in summer had lower viscosity and poorer moldability than the one made in winter .The amount of beeswax increased in the adjusted prescription .Three batches of urea ointment were prepared with the new prescription and their stability was maintained .There were no changes in appearance , and the content and microbial limit remained in the standard range for 11 months.Conclusion The source of materials and change of the external environment could affect the characteristics of urea ointment .The adjusted prescription is feasible and stable .
ABSTRACT
Objective To evaluate the effect of topical olive oil, vaseline cream and menthol ointment on skin barrier function of patients with senile xerosis. Methods Totally 32 participants with senile xerosis were enrolled in this randomized double-blind self-controlled study for 8 weeks. Four black square spaces were marked on bilateral forearms of each volunteer, and three were treated with olive oil, vaseline cream and menthol ointment, respectively, once a day for 8 weeks, and the last one was taken as control. Skin barrier function was evaluated at 2, 4, and 8 weeks after experiment by measuring the water content of the stratum corneum, transepidermal water loss (TKWL), and skin pH value. Results Compared with the control group, the water contents of stratum corneum in the olive oil, vaseline cream and menthol ointment groups were significantly increased (P<0.05), and the TEWL value and skin pH value were significantly decreased (P<0.05) at 8 weeks. There were no significant difference in the water content of stratum corneum, TEWL value, or pH value between 3 experiment groups. Conclusion Topical olive oil can improve the skin barrier function of patients with senile xerosis, and vaseline cream and menthol ointment also can repair the skin barrier function.
ABSTRACT
Objective To explore the effects of vaseline gauze combined with brain cotton piece on eye protection during otological surgery . Methods From January to March in 2015 , 80 patients with otological surgery were set as the experiment group , where vaseline gauze and brain cotton piece were used to protect eyes . From October 2014 to December 2014 , another 80 patients with otological surgery were set as the control group , where aureomycin eye ointment was used for eye protection . The two groups were compared in terms of complications incidence . Result The complication incidence of the experiment group was significantly lower than that of control group ( P < 0 . 01 ) . Conclusion Vaseline gauze and brain cotton piece can effectively protect the eyes for patients undergoing otological surgery , lower the occurrence rate of fewer complications and improve patients′comfort .
ABSTRACT
O traumatismo no períneo ocorre com frequência durante o parto vaginal e algumas técnicas e práticas têm sido utilizadas, entre elas o uso de vaselina, com a finalidade de reduzir esses danos. Assim, os objetivos foram: verificar a frequência, o local e o grau de laceração perineal, relacionando-o ao uso de vaselina líquida no períneo durante o período expulsivo do parto normal; identificar a duração do período expulsivo, relacionando-a ao uso de vaselina líquida na região perineal e relacionar a ocorrência de laceração perineal com o peso dos recém-nascidos, peso materno e paridade. Trata-se de um estudo experimental, aleatório, controlado do tipo ensaio clínico, realizado no Centro de Parto Normal do Amparo Maternal, instituição filantrópica localizada na cidade de São Paulo. A amostra foi composta por 76 parturientes sem parto vaginal anterior, distribuídas em dois grupos: Grupo Experimental - 38 parturientes que receberam lubrificação com vaselina líquida na região perineal durante o período expulsivo; Grupo Controle - 38 parturientes que não receberam lubrificação com vaselina líquida na região perineal durante o período expulsivo. Os resultados mostraram que a frequência de laceração perineal foi semelhante nos dois grupos (experimental 63,2% versus controle 60,5%). Houve predomínio de lacerações de primeiro grau nos dois grupos (72,3%) e o local de maior ocorrência foi no períneo posterior (53,2%), sem diferença estatística entre os grupos. Não foi constatada diferença estatística entre os dois grupos quanto à duração do período expulsivo. Observou-se que a vaselina aplicada no períneo durante o período expulsivo não reduziu a lesão do assoalho pélvico e a condição do períneo independe do peso do recém-nascido, do peso materno e da paridade. A prevenção do trauma perineal pode estar associada a outros fatores, como relaxamento da musculatura perineal próprio de cada mulher, menor peso fetal, puxo ) espontâneo, desprendimento fetal lento, posição materna no parto e prática de quem assiste ao parto
Perineal trauma occurs frequently during vaginal birth and some techniques, among which the use of vaseline, have been utilized to reduce this damage. The objectives of this study were: to verify the frequency, location, and degree of perineal laceration, associating the latter with the use of liquid Vaseline on the perineum during the second stage of normal birth; to identify the duration of the second stage relating it to the use of liquid Vaseline in the perineal region; to associate the occurrence of perineal lacerations with birthweight, maternal weight and parity. This is a randomized controlled clinical study undertaken in the Centro de Parto Normal [Normal Birth Center] of the Amparo Maternal Maternity, a philanthropic institution located in the city of Sao Paulo. The sample was composed of 76 women in labor with no previous vaginal deliveries, distributed in two groups: an Experimental Group - 38 women in labor whose perineal region was lubricated with Vaseline during the second stage; and, the Control Group - 38 women in labor whose perineal region was not lubricated with Vaseline during the second stage. The results indicate that the frequency of perineal laceration was similar in both groups ( 63.2% of the experimental group versus 60.5% of the control group). First degree lacerations predominated in both groups (72.3%) and the location where laceration occurred most frequently was the posterior perineum (53.2%), with no statistical difference between groups. There wasn't any statistical difference between the groups as to the duration of the second stage of labor. It was observed that applying Vaseline in the perineal region did not reduce lesions in the pelvic floor nor in the condition of the perineum independently of birthweight, maternal weight and parity. The prevention of perineal trauma may be associated to other factors, such as the degree of relaxation of the perineal muscles of each woman, smaller birthweight, spontaneous distention, slow fetal detachment, maternal position during delivery, and the experience of the professional assisting the woman in childbirth