ABSTRACT
Objective To investigate the clinical effect of ergometrine maleate injection combined with posterior pituitary injection in the treatment of postpartum hemorrhage.Methods From April 2016 to July 2018, 68 patients with postpartum hemorrhage treated in the Maternal and Child Health Care Hospital of Tongxiang were randomly divided into two groups according to the random number table ,with 34 patients in each group .The control group was treated with posterior pituitary injection .The observation group was treated with ergometrine maleate injection combined with posterior pituitary injection .The bleeding volume at different time points after treatment was compared between the two groups .The hemostasis time, the duration of uterine contraction , the extent of uterine decline,the duration of lochia and serum cytokines levels before and after treatment were compared .Results The bleeding amount at 0.5 h,2 h,24 h after administration in the observation group were (76.82 ±15.40) mL,(112.34 ± 18.73) mL and (196.70 ±20.60) mL,respectively,which were significantly lower than those in the control group [(147.38 ±17.65),(198.49 ±19.37) mL,(283.74 ±21.56) mL](t=17.565,18.643,17.020,all P<0.05). The duration of contractions[(3.83 ±1.40) h] and the extent of uterine decline[(6.25 ±0.93) cm] in the observation group were significantly better than those in the control group [(1.92 ±0.59) h,(4.65 ±0.66) cm],and the hemostasis time[(21.29 ±3.60) min] and duration of lochia [(17.19 ±4.67) d] in the observation group were significantly shorter than those in the control group[(42.28 ±3.85) min,(24.28 ±6.11) d](t=23.220,7.331, 8.181,5.376,all P<0.05).After treatment,the levels of nitrogen monoxide (NO)[(91.22 ±6.23)μmol/L], nitric oxide synthase (NOS)[(24.56 ±2.46)μmol/L],brain natriuretic peptide (BNP)[(46.81 ±5.10)ng/L] in the observation group were lower than those in the control group [(98.63 ±7.51)μmol/L,(30.92 ±3.95)μmol/L, (90.35 ±4.66)ng/L],and the differences were statistically significant (t=4.428,7.969,36.750,all P<0.05). Conclusion The effect of ergometrine maleate injection combined with posterior pituitary injection on postpartum hemorrhage is effective , which can effectively control the amount of bleeding , shorten the time of hemostasis and promote postpartum recovery .
ABSTRACT
Objective@#To investigate the clinical effect of ergometrine maleate injection combined with posterior pituitary injection in the treatment of postpartum hemorrhage.@*Methods@#From April 2016 to July 2018, 68 patients with postpartum hemorrhage treated in the Maternal and Child Health Care Hospital of Tongxiang were randomly divided into two groups according to the random number table, with 34 patients in each group.The control group was treated with posterior pituitary injection.The observation group was treated with ergometrine maleate injection combined with posterior pituitary injection.The bleeding volume at different time points after treatment was compared between the two groups.The hemostasis time, the duration of uterine contraction, the extent of uterine decline, the duration of lochia and serum cytokines levels before and after treatment were compared.@*Results@#The bleeding amount at 0.5 h, 2 h, 24 h after administration in the observation group were (76.82±15.40) mL, (112.34±18.73) mL and (196.70±20.60) mL, respectively, which were significantly lower than those in the control group[(147.38±17.65), (198.49±19.37) mL, (283.74±21.56) mL](t=17.565, 18.643, 17.020, all P<0.05). The duration of contractions[(3.83±1.40) h] and the extent of uterine decline[(6.25±0.93) cm] in the observation group were significantly better than those in the control group[(1.92±0.59) h, (4.65±0.66) cm], and the hemostasis time[(21.29±3.60)min] and duration of lochia[(17.19±4.67)d] in the observation group were significantly shorter than those in the control group[(42.28±3.85) min, (24.28±6.11) d](t=23.220, 7.331, 8.181, 5.376, all P<0.05). After treatment, the levels of nitrogen monoxide (NO)[(91.22±6.23) μmol/L], nitric oxide synthase (NOS)[(24.56±2.46) μmol/L], brain natriuretic peptide (BNP)[(46.81±5.10)ng/L] in the observation group were lower than those in the control group[(98.63±7.51) μmol/L, (30.92±3.95) μmol/L, (90.35±4.66)ng/L], and the differences were statistically significant (t=4.428, 7.969, 36.750, all P<0.05).@*Conclusion@#The effect of ergometrine maleate injection combined with posterior pituitary injection on postpartum hemorrhage is effective, which can effectively control the amount of bleeding, shorten the time of hemostasis and promote postpartum recovery.
ABSTRACT
Objective To study the effects of oxytocin antagonists-atosiban on pregnancy outcome after thaw embryo transfer (TET).Methods Between Jul.and Dec.2012,a total of 120 women undergoing TET in Reproductive Medical Center,General Hospital of Tianjin Medical University were randomly allocated into atosiban and control group.They were all transferred 2 or 3 top quality embryos at phase of 7-8 cells.Patients in atosiban group were administered by intravenous administration of atosiban before 30 minutes of embryo transfer with a total administered dose of 37.5 mg.In the control group,no special treatment was given before embryo transfer.All patients in 2 groups underwent progesterone luteal support regularly after embryo transfer,then the clinical rate of pregnancy,implantation and early abortion was compared.Results The clinical pregnancy rate per cycle and implantation rate per transfer were 60％(36/60) and 30.0％ (48/160) in the atosiban group,which were higher than 42％ (25/60) and 20.3％ (31/153) in the control group (all P ＜ 0.05).Early abortion rate was 6％ (2/36)in the atosiban group,which was no statistical difference comapring with control group [16％ (4/25),P ＞ 0.05].Conclusion It was suggested that atosiban treatment before embryo transfer can improve the outcome of pregnancy,and increase clinical pregnancy rate and implantation rate after TET.
ABSTRACT
Objective To investigate the effectiveness of oxytoein antagonist atosiban in the alternative rescue therapy of preterm labor.MethodsAlternative toeolysis atosiban was given as rescue therapy to 35 women,who had received ritodrine or magnesium sulphate but failed,due to either progression of labour or intolerable adverse events.Atosiban was administered for up to 48 hours.Efficacy and tolerability were assessed based on the proportion of women who did not deliver and did not need alternative toeolytie therapy at 48 hours and 7 days after therapy initiation.The numbers of maternal adverse events and neonatal morbidity were also assessed.ResultsEfficacy and tolerability at 48 hours and 7 days after atosiban nitiation were 77％(27/35)and 60％(21/35).One woman presented drug-related side effects with mild nausea and omiting.Thirty-four women have delivered and one bigemina(28 weeks)is being followed-up.In 34 women,11 delivered before 28 gestational weeks,17 delivered after 28 gestational weeks,3 delivered after 34 weeks and 3 had term delivery.Pregnancies were rolonged by 4 hours to 14+2 weeks.There were nine neonatal deaths,with gestational ages less than 28 weeks at delivery.Conclusion xytocin antagonist atosiban could be given as alternative rescue therapy if therapy with ritodrine or magnesium sulphate fails in the treatment of preterm labor,and it is safe and effective.
ABSTRACT
Arginine vasotocin has long been known as an antidiuretic hormone in non-mammalian vertebrates. The peptide has also been found in mammalian tissues. The physiological significance of the peptide, however, has not yet been clarified in mammals. To define the effect of arginine vasotocin on the water and electrolyte balance in mammalian vertebrates, experiments have been done. Intrarenal arterial infusion of arginine vasotocin, 0.01-10ng/kg/min resulted in dose-dependent decreases in urine volume and free water clearance and an increase in urinary osmolarity. Arginine vasotocin, in a dose of 0.03ng/kg/min, induced an increase in water reabsorption without changes in glomerular filtration rate. Intrarenal infusion of arginine vasotocin in doses ranging from 0.1 to 3.0 or 10.0ng/kg/min resulted in decreases in glomerular filtration rate and renal plasma flow. However, no dose dependence were observed. Intrarenal infusion of arginine vasotocin from 0.3 to 10 ng/kg/min induced dose-dependent natriuretic and kaliuretic effects with concomitant suppression of renin secretion. The renal effects of arginine vasotocin were blocked by arginine vasopressin V2-receptor antagonist [d(CH2)5, D-Phe2, Ile4, Ala9-NH2]-vasopressin but were not blocked by[d(CH2)5, D-Ile2, Ile4, Arg8]- vaso pression. These data suggest that the effect of arginine vasotocin on the renal function are similar to that of vasopressin in mammalian vertebrates. The data also suggest that the renal effects of arginine vasotocin may be coupled to the receptor system which is similar, if not identical, to that of arginine vasopressin.