Combined ablative fractional Er ∶ YAG laser and 10％ ALA-PDT in treatment of refractory verruca plana / 中华医学美学美容杂志

Objective To evaluate the efficacy of combined therapies of ablative fractional Er ∶YAG laser (2,940 nm) and ALA-PDT on refractory verruca plana.Methods 120 cases of refractory verruca plana patients were randomly divided into two groups:60 cases in the control group and 60 cases in the experimental group.The control group used 10％ ALA-PDT with LED irradiation of a power density 70 of mW/cm2 at a distance of 20 cm,which lasted for 20 min each time.The experimental group was treated with ablative fractional Er ∶ YAG laser (2,940 nm) first with the fluence of 500P/cm2 and short pulse duration,and then treated 10％ ALA-PDT as mentioned before.Every patient was treated twice at two-week intervals.Three independent investigators evaluated subject outcomes at 3 months post-treatment including efficacy and side-effects.Results The effective rate of the experimental group was 86.44 ％ at 3 months post-treatment after one to two times.Meanwhile,the control group was 59.65 ％.The clinical outcome of experimental group was better than the control group.There was significant difference between the two groups (P＜0.05).The recurrent rate of experimental group was 3.39％ and 12.30％ in control group.There was significant difference between the two groups (P＜0.05).There were no obvious side-effects in both groups.Conclusions Ablative fractional laser with low fluence promotes the transdermal absorption of ALA and enhances the efficacy of PDT.

A Case of Combination Treatment with Oral Acitretin and Topical 5% Imiquimod Cream in an Immunosuppressive Patient with Widespread Verruca Plana / 대한피부과학회지

Verruca plana is a subtype of warts, which are one of the most common dermatological diseases. A 37-year-old man presented with multiple asymptomatic skin-colored, 1∼2-mm, flat-topped papules on both arms, neck, and face. The patient had ulcerative colitis, which had been treated with immunosuppressants for 15 years. After skin biopsy, verruca plana was confirmed. The patient was treated with 5% imiquimod cream for 6 months. However, only mild improvement was observed. Acitretin was then added to the treatment regimen. After 44 weeks of treatment, acitretin was stopped. Dramatic and rapid clinical improvement was achieved after 3 weeks of treatment, and no sign of recurrence after treatment cessation has been reported for 60 weeks. Consequently, the combination of oral acitretin and topical 5% imiquimod cream should be recommended for the effective and safe treatment of recalcitrant verruca plana in immunosuppressed patients.

Cure Warts Capsules Combined with Burt's res-q Ointment in the Treatment of 40 Cases of Verruca Plana / 浙江中医药大学学报

[Purpose] To observe the clinical effects, relapse rate and security of treating the verruca plana with the cure warts capsules combined with Burt's res-q ointment. [Methods] Eighty patients with verruca plana were randomly divided into two groups. Forty patients in the combination group received cure warts capsules combined with Burt's res-q ointment; others in the control group received 0.1% al-transretinoic acid cream only. The courses of treatment of two groups was four weeks, then observe the number of verruca plana and bad reaction after the treatment, and record four weeks fol ow-up observation of relapse. [Results] The effective rate of treatment group was 92.50%which was significantly higher than the control group that the effective rate was 50.00% , and the former’s relapse rate was 3.40% which was significantly lower than that in the group which was 44.40% , the above showed significant difference(P<0.05).There was no significant side effects in the two groups. [Conclusion] Cure warts capsules combined with Burt's res-q ointment had better effect, low relapse rate and high safety.

Verruca Plana: Effect of Skin Care Behavior in Skin Care Clinics and Skin Care Shops / 대한피부과학회지

BACKGROUND: Verruca plana is a common viral disease that commonly affects the face. It can autoinoculate or autotransmit, as well as cause many cosmetic problems. Skin care material that had direct contact with the skin of an affected person during a skin care procedure can be a transmission route of verruca plana or a risk factor of autoinoculation of the virus. OBJECTIVE: The goal of this study is to compare skin care behavior between skin care clinics and skin care shops, and the effects on verruca plana transmission. METHODS: Seventy-four patients who visited local dermatology clinics in Daegu from January 2011 to January 2013 were selected randomly, and a questionnaire survey was done. RESULTS: The incidence of verruca plana in patients visiting the clinic to receive skin care was higher than in the normal population. There was a statistically significant correlation between the number of procedures and the incidence of verruca plana in both skin care clinics and skin care shops. Whereas the number of verruca plana cases increased with the increase in the number of procedures in skin care shops, there was no significant correlation between the number of procedures and the incidence of verruca plana in skin care clinics. CONCLUSION: The number of procedures was significantly correlated with the incidence of verruca plana. In persons receiving treatment in skin care shops, the incidence of verruca plana increased with the increase in the number of procedures.

Morphea and Verruca Plana Complicated in Central Diabetes Insipidus / 대한피부과학회지

Morphea, localized scleroderma, is a connective tissue disease characterized by localized, circumscribed sclerotic patches, or plaques of the skin. The pathogenesis of morphea is still unclear. Central diabetes insipidus is a disease characterized by excessive thirst and urination. In more than half of the cases of central diabetes insipidus, the etiology is still unknown. We experienced the case of morphea and verruca plana in a 32-year old female with a history of central diabetes insipidus. Central diabetes insipidus might have influenced disrupting the homeostasis of the endocrine or immune environment. In the state of disrupted homeostasis, there might be an increased chance for morphea and disseminated verruca plana to develop easily. Based on this, we suppose the possible mechanism about the morphea and disseminated verruca plana developed in central diabetes insipidus.

Morphea and Verruca Plana Complicated in Central Diabetes Insipidus / 대한피부과학회지

Morphea, localized scleroderma, is a connective tissue disease characterized by localized, circumscribed sclerotic patches, or plaques of the skin. The pathogenesis of morphea is still unclear. Central diabetes insipidus is a disease characterized by excessive thirst and urination. In more than half of the cases of central diabetes insipidus, the etiology is still unknown. We experienced the case of morphea and verruca plana in a 32-year old female with a history of central diabetes insipidus. Central diabetes insipidus might have influenced disrupting the homeostasis of the endocrine or immune environment. In the state of disrupted homeostasis, there might be an increased chance for morphea and disseminated verruca plana to develop easily. Based on this, we suppose the possible mechanism about the morphea and disseminated verruca plana developed in central diabetes insipidus.

Facial Verruca Plana That Developed after Semipermanent Tattooing

Tattooing is becoming more popular around the world. As a result, the reported complications of tattoo are increasing. Local inflammation, infection and allergic reactions are the most common adverse effects. We report here on a healthy 39-year-old woman who developed multiple verruca plana lesions after undergoing semipermanent tattooing. The tattooing had been done 1 year earlier by an amateur.

Therapeutic Effect of Oral Itraconazole for Verruca Plana / 대한피부과학회지

BACKGROUND: Despite numerous therapeutic methods (destructive surgery, topical application or systemic administration of various medicaments), the treatment of verruca plana still remains unsatisfactory and some novel remedies have been required. The authors noticed incidentally the clearance of verruca plana lesions in a patient who received itraconazole for tinea pedis. OBJECTIVE: The purpose of this study was to investigate the therapeutic effects of itraconazole for verruca plana. METHODS: The patients with verruca plana were treated with itraconazole (200 mg/day for adults, and 100 mg/day for children below 10 years of age) for 2 weeks. Assessment of clinical response and occurrence of the side effects were examined at weekly intervals. RESULTS: Of the 20 patients, 11 patients (55.0%) had either complete (40.0%) or partial clearance (15.0%) of verruca plana within 2 weeks of itraconazole therapy without severe adverse effects. No significant differences in therapeutic responses were found with regard to ages, sexes and duration of the diseases. CONCLUSION: This study demonstrates that oral itraconazole could be an effective and safe candidate in the treatment of verruca plana.

Three Cases of Verruca Plana Treated Successfully with 5% Imiquimod Cream

No abstract available.

The Effects of 5% Imiquimod Cream on Verruca Plana / 대한피부과학회지

BACKGROUND: Verruca plana is a cutaneous human papillomavirus (HPV) infections. Although various treatments such as destructive methods or immunomodulating agents have been used, none are uniformly effective or prevent recurrence. Ideal treatment for verruca plana should target on an increasing local immune response to the HPV infection. Recently, imiquimod, a topical immune- response modifier, has been successfully used in the treatment of external anogenital warts. OBJECTIVE: The aim of this study was to determine the efficacy and safety of 5% imiquimod cream for the treatment of verruca plana. METHOD: Seven patients with verruca plana were treated with 5% imiquimod cream 3 times a week. at night, for 16 weeks or until complete clearance of lesions had occured. During the follow- up period, the onset time of effects, clearance rate, side effects, and recurrence rate were recorded. At 16 weeks after treatment, a clearance rate was determined by a 3 scale rating; complete-100% clearance / partial-less than 100% clearance / failure-no clearance. RESULTS: The onset time of effects ranged from 1 to 4 weeks (mean-1.7 weeks). The clearance rate at 16 weeks after treatment were as follows; complete-4 (57.1%), partial-2 (28.6%), and failure - 1 (14.2%). No patient showed systemic side effects or long-term adverse effects such as pigmentary disorders or scarring. In the subjective local skin reactions, itching was the only symptom and was common (4/7, 57.1%). With objective skin reactions, erythema was the most common (4/7, 57.1%), followed by erosion and scabbing (2/7, 28.6%). In long-term follow-up of those patients who showed complete clearance, no one encountered recurrence. CONCLUSION: This data demonstrates that 5% imiquimod cream is an effective and promising treatment modality for verruca plana. Because it is non-destructive, safe, and easy to use, it resulted in an excellent cosmetic outcome.

The Clinical Effect of 5% Imiquimod Cream in the Treatment of Verruca Plana / 대한피부과학회지

BACKGROUND: Despite numerous therapeutic options, the treatment of verruca plana remains unsatisfactory for both patients and physicians. Imiquimod, a novel topical immune response modifier, has been successfully used for the treatment of external anogenital warts. OBJECTIVE: The purpose of this study was to investigate the efficacy of imiquimod in treatment of verruca plana. METHOD: Fifteen patients with verruca plana were treated with 5% imiquimod cream that was self-applied 3 times a week and left in place overnight. Assessment for responses and side effects was performed every 2 weeks until clinical cure or up to 12 weeks. RESULTS: 10 of 15 (66.7%) patients achieved a excellent result (>75% improvement), and 11 (73%) patients achieved a good result (>50% improvement). With regard to the location of the lesions, 10 of 12 (83%) patients with lesions on the face and neck achieved a clear result (>95% improvement), but only 2 of 7 (28%) patients with lesions on the extremities achieved a clear result. Local inflammatory reactions were the most common adverse events, however, they were generally mild and transient. CONCLUSION: 5% imiquimod cream, applied by the patient, is an effective treatment modality for verruca plana.

Treatment of Verruca Plana with High Dose Cimetidine Therapy / 대한피부과학회지

BACKGROUND: It is often a difficult problem for dermatologists to treat verruca plana. Cimetidine is a H2 histamine receptor antagonist that has been used mainly to treat peptic ulcer disease. The successful use of cimetidine in the treatment of viral warts has been reported previously using doses of 40mg/kg/day and has the advantage of being painless and easy to administer. OBJECTIVE: The purpose of this study was to evaluate the clinical effects of high dose cimetidine therapy for verruca plana. METHODS: Thirty-six patients with verruca plana were treated with high dose cimetidine therapy (22 females, 14 males; age range 7-56 years). RESULTS: Of the 36 patients who completed the study, 15 patients (41.7%) showed complete remission. 8 patients (22.2%) showed partial remission. There was no significant differences among the complete remission, the partial remission and the no response groups. There were a few adverse effects including transient liver enzyme elevation and gynecomastia which were normalized after the cimetidine was discontinued. CONCLUSION: High dose cimetidine therapy is an effective treatment modality for verruca plana without severe adverse effects.