Comparison of clinical characteristics and vestibular function test results in patients with vestibular migraine and Menière's disease

Abstract Objectives The differentiation between Vestibular Migraine (VM) and Meniere's Disease (MD) is difficult because of overlapping symptoms. The study aimed to compare the clinical characteristics and vestibular function test results between VM and MD patients. Methods Seventy-one patients with definite VM and 31 patients with definite unilateral MD were included. All patients received Caloric Test (CT), Video Head Impulse Test (vHIT) and Vestibular Evoked Myogenic Potential (VEMP) test within 7 days after visiting the hospital. Results of these tests were compared between groups. Results Most VM patients (64.0%) experienced spontaneous internal vertigo, while most MD patients (66.7%) experienced spontaneous external vertigo. MD patients had more severe vestibular symptoms and autonomic responses compared to VM patients during attacks (p= 0.03, p= 0.00, respectively). The nystagmus intensity of CT-induced was greater in VM patients than in MD patients (p= 0.003). More VM patients had CT intolerance and Central Positional Nystagmus (CPN) compared to MD patients (p= 0.002, p = 0.006, respectively). More MD patients had CT(+) and vHIT saccades wave compared to VM patients (p< 0.001, p= 0.002, respectively). The non-elicitation rate of cervical VEMP was higher, and the ocular VEMP amplitudes were lower in MD patients than in VM patients (p = 0.002, p= 0.018). Conclusions Vestibular symptoms during attacks combined with the results of vestibular function tests may be used to differentiate between VM and MD. The diverse nature of vestibular symptoms (especially internal vertigo), history of motion sickness and CT intolerance may provide clues to the diagnosis of VM, whereas spontaneous external vertigo, CT(+) with vHIT(-), and the presence of saccades may provide clues to the diagnosis of MD. Level of evidence: 4.

Efeito da idade no equilíbrio corporal e nos resultados do vídeo teste do impulso cefálico em pacientes com insuficiência cardíaca / Effect of age on body balance and on the results of the video head impulse test in patients with heart failure

RESUMO Objetivo verificar se existe associação entre a avaliação clínica do equilíbrio e o ganho do reflexo vestíbulo-ocular com o avanço da idade em pacientes com insuficiência cardíaca. Métodos estudo transversal analítico-descritivo, de caráter observacional, que incluiu pacientes com diagnóstico de insuficiência cardíaca, divididos em dois grupos, por idade (G1, menos de 60 anos e G2, 60 anos ou mais). Os pacientes foram avaliados por meio de anamnese, avaliação cardiológica, avaliação clínica do equilíbrio corporal (triagem da função cerebelar e avaliação do equilíbrio estático e dinâmico) e instrumental da função vestibular (Video Head Impulse Test-vHIT). Os achados obtidos foram descritos e comparados por meio de análise estatística inferencial. Resultados foram avaliados 34 pacientes com média de idade de 55 anos e 9 meses, a maioria homens (71,49%). Não houve associação do ganho do reflexo vestíbulo-ocular, simetria dos canais semicirculares e avaliações do equilíbrio corporal com o avanço da idade. Observaram-se associações entre os resultados da prova de Unterberger-Fukuda com o ganho do reflexo vestíbulo-ocular do canal semicircular lateral direito e posterior esquerdo e com os percentuais de simetria dos canais semicirculares anteriores para os pacientes do Grupo 2. Para os indivíduos do Grupo 1, foi observada associação entre os resultados da prova de Unterberger-Fukuda com os valores de simetria dos canais semicirculares anteriores e do ganho de reflexo vestíbulo-ocular dos canais semicirculares anterior esquerdo e posterior direito. Conclusão não houve associação entre os resultados da avaliação clínica do equilíbrio corporal e dos achados do vHIT com o avanço da idade, em pacientes com insuficiência cardíaca. Entretanto, observou-se diferença entre o ganho do reflexo vestíbulo-ocular específico para alguns canais semicirculares, com maiores índices de alteração na prova de equilíbrio dinâmico, em ambos os grupos. Os resultados dos testes aplicados permitiram caracterizar o predomínio da hipofunção vestibular crônica de origem periférica nos pacientes com insuficiência cardíaca, independentemente da faixa etária.

ABSTRACT Purpose to verify whether there is an association between the clinical assessment of balance and the gain in the vestibulo-ocular reflex with advancing age in patients with heart failure. Methods analytical-descriptive, observational cross-sectional study, which included patients diagnosed with heart failure, divided into two groups by age (G1, under 60 years old and G2, 60 years old or older). The patients were evaluated through anamnesis, cardiac assessment, clinical assessment of body balance (cerebellar function screening and assessment of static and dynamic balance) and instrumental assessment of vestibular function (Video Head Impulse Test-vHIT). The findings were described and compared through inferential statistical analysis. Results 34 patients with a mean age of 55 years and 9 months, mostly men (71.49%). There was no association between vestibulo-ocular reflex gain, symmetry of the semicircular canals and body balance with advancing age. Associations were observed between the results of the Unterberger-Fukuda test with the gain in the vestibulo-ocular reflex of the right lateral and left posterior semicircular canals and with the percentages of symmetry of the anterior semicircular canals for patients in Group 2. In Group 1, an association was observed between the results of the Unterberger-Fukuda test and the symmetry values of the anterior semicircular canals and the gain in the vestibulo-ocular reflex of the left anterior and right posterior semicircular canals. Conclusion there was no association between the results of the clinical assessment of body balance and the vHIT findings with advancing age in patients with heart failure. However, there was a difference between the gain of the specific vestibulo-ocular reflex for some semicircular canals, with higher rates of alteration in the dynamic balance test, in both groups. The results of the applied tests allowed characterize the predominance of chronic vestibular hypofunction of peripheral origin in patients with heart failure, regardless of age group.

Audio-vestibular and radiological analysis in Meniere's disease

Abstract Objective: Intravenous gadolinium-enhanced inner ear magnetic resonance imaging (IV Gd-enhanced inner ear MRI) is a new technique for diagnosing Meniere's disease (MD). Vestibular tests have also long been used forMD, but which tests should be included in the oto-neurological test battery remains controversial. The evaluation method to be used to confirm the clinical diagnosis in MD is not clear. This study aimed to examine the results of vestibular tests and IV Gd-enhanced inner ear MRI in individuals diagnosed with unilateral definite Meniere's disease. Methods: IV Gd-enhanced inner ear MRI (Endolymphatic Hydrops [EH] and Perilymphatic Enhancement [PE]), conventional audiometry (0.25-8kHz), video Head Impulse Test (vHIT), cervical Vestibular Evoked Myogenic Potential (cVEMP), air caloric test, and dizziness handicap inventory were applied to 16 adult patients diagnosed with unilateral definite MD. Results: Among the patients with definite MD, EH (cochlear and/or vestibular) was identified in 93.7% and 68.7% of the symptomatic and the asymptomatic ears, respectively. There was a positive correlation between the hearing thresholds at 2, 4, 6 and 8 kHz and the degree of cochlear EH (p < 0.05). PE (cochlear and/or vestibular) was observed in 37.5% of the asymptomatic and symptomatic ears. The sensitivity of the vestibular test battery (vHIT, cVEMP, and caloric test) was 100% and its specificity was 50%, while the sensitivity of the IV Gd-enhanced inner ear MRI (EH and PE together) was 93.8% and the specificity was 81.3%. Conclusion: MRI had higher sensitivity and specificity than the vestibular test battery. PE or vHIT alone was not considered to be reliable in the diagnosis of MD. In suspected MD, the clinical history, hearing tests, and IV Gd-enhanced inner ear MRI are sufficient for diagnosis. If MRI technique is not possible, vestibular tests (caloric test and cVEMP, not vHIT) can provide reliable results when evaluated together.

Robert Bárány, o criador da Neuro-otologia / Robert Bárány the founder of Neuro-otology

O vienense Robert Bárány criou a Neuro-otologia. Este artigo ressalta um pouco da sua vida e obra, que certamente não foram das mais serenas. Cientista por excelência, enfrentou um processo iniciado por seus pares, que alegavam uso impróprio de dados e falta de ética. Alistou-se como médico na guerra austríaco-russa, foi preso e, em 1914 e ainda no campo de prisioneiros, recebeu o Prêmio Nobel. Exilou-se voluntariamente na Suécia, onde passou boa parte de sua vida, e morreu antes de completar 60 anos.

The Viennese Robert Bárány created the Neuro-otology. This article highlights some of his life and work, which certainly were not the most serene. Scientist par excellence, faced a process initiated by his peers, who alleged misuse of data and lack of ethics. He enlisted as a physician in the Austrian-Russian war, and was arrested in prisoners? camp. In 1914 and still in the camp received the Nobel Prize. Volun-tarily went into exile in Sweden, where he spent much of his life and died before completing 60.

Evaluación de la función vestibular angular: prueba de impulso cefálico multiaxial a ojo desnudo / Angular vestibular function assessment: Multiaxial Head Impulse Test

Introducción: La prueba de impulso cefálico consiste en un examen rápido, sencillo para evaluar la función vestibular angular. Clásicamente se utiliza para el canal horizontal, pero puede implementarse para evaluar los canales semicirculares anteriores y posteriores. Objetivo: Explorar la sensibilidad y especificidad de esta prueba para los canales verticales a ojo desnudo en nuestro medio, en relación a la prueba calórica. Material y método: Estudio prospectivo de evaluación de test diagnóstico. Se realizó prueba de impulso cefálico para todos los canales semicirculares a pacientes con indicación de evaluación funcional de VIII par. Resultados: Se evaluaron 118 pacientes, donde 49,2% presentó una prueba calórica clásica alterada. La sensibilidad del impulso cefálico para el canal posterior fue 13,1(0)% (y 3,2%% para el canal anterior) con una especificidad de 100%% para ambos. Para el canal horizontal la sensibilidad fue de 63,9%% y la especificidad de 100%%. Discusión: La prueba de impulso cefálico para los canales anteriores y posteriores a ojo desnudo es altamente específico, pero muy poco sensible, teniendo una utilidad relativa dentro de la clínica, a diferencia de la misma prueba para el canal horizontal que con la misma especificidad pero con una sensibilidad aceptable representa un examen rápido y de simple ejecución.

Introduction: The Head Impulse Head test represents a quick and simple technique for perioheral vestibular function assessment, by means of exploring the vestíbulo-ocular reflex. It is usually períormed on the horizontal semicircular canals planes, but it can also explore the anterior and posterior canals. Aim: To assess the head impulse test's sensitivity and specificity for the anterior and posterior canals on a bedside scenario, taking the classic caloric test as gold standard. Material and method: Prospective test-assessment study. A head impulse test for every semicircular canal was períormed on patients with indication of vestibular study with caloric test. Results: 118 patients were evaluated, where 49,2%% presente an abnormal caloric test. The head impulse test's sensitivity for the posterior canal canal was 13,1%% (3,2%% for the anterior canal). The test's specificity was 100%% for both vertical canals. On the horizontal plane, sensitivity reached 63,9%%, while specificity was 100%% Discussion: The head impulse test for vertical (anterior and posterior) canal on a bedside scenario is highly specific but poorly sensitive, thus having a relatively low clinical utility. On the contrary the test for the horizontal canal remains a quick and simple tool, with acceptable sensitivy and great sensitivity for assessing vestibular function loss.