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Objective@#To observe and explore the therapeutic efficacy of hyperbaric oxygen (HBO) in the treatment of non-arteritic anterior ischemic optic neuropathy (NAION).@*Methods@#A total of 139 NAION patients were randomly divided into a control group of 72 and a hyperbaric oxygen group of 67. Both groups were given conventional drugs including prednisolone, mecobalamin and compound anisodine, while the hyperbaric oxygen group was additionally provided with hyperbaric oxygen treatment at a pressure of 0.2MPa once a day for 30 days. Each day′s treatment lasted for 110 minutes, including 20 minutes at increasing pressure, 20 minutes decreasing and 60 minutes with the pressure stable at 0.2MPa. Before and after the 30-day treatment, the visual acuity and visual mean sensitivity (MS) of the two groups were observed and compared.@*Results@#There was no significant difference between the control group and the hyperbaric oxygen group in terms of average visual acuity or visual MS before the treatment. Afterward the average visual acuity (4.88±0.25) and visual MS (16.68±1.19) of the hyperbaric oxygen group were significantly higher than before the treatment and significantly better than those of the control group. The total effective rate of the hyperbaric oxygen group was 91%, significantly higher than that of the control group (75%).@*Conclusions@#Conventional treatment combined with hyperbaric oxygen therapy can significantly promote the visual acuity and visual MS of NAION patients.
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@#AIM: To investigate the clinical effect of Qi Ming granule combined with calcium dobesilate in treatment of non-proliferative diabetic retinopathy(NPDR).<p>METHODS: Totally 94 patients with I～III stage NPDR in our hospital from January 2014 to May 2016 were collected and randomly divided into control group and observation group, all were unilateral, with 47 eyes in each group. The two groups were given control of blood glucose, diet and exercise therapy and other conventional treatment. The control group were treated with conventional western medicine calcium dobesilate treatment, 0.5g,3 times per day, the observation group combined with Qi Ming granule treatment based on control group treatment. Both groups were treated for 3mo. Two groups were observed before and after treatment for visual sensitivity and changes of serum cytokines \〖vascular endothelial growth factor(VEGF)and insulin-like growth factor-1(IGF-1), pigment epithelium derived factor(PEDG)\〗. Therapeutic effect and safety of the two groups were comprehensively evaluated and compared. <p>RESULTS: The average sensitivity of the observation group after treatment was lower than that before treatment and the control group after treatment, the difference were statistically significant(<i>P</i><0.05).The VEGF,IGF-1,PEDG of observation group after treatment, were significantly improved compared with the control group, the difference were statistically significant(<i>P</i><0.05). There were no obvious adverse reactions in the two groups, the total effective rate was 89% in the observation group, which was higher compared with the control group 72%, and the difference was statistically significant(<i>P</i><0.05). <p>CONCLUSION: Qi Ming granule combined with western medicine in the treatment of DR can effectively improve the function of the retina and ease the progress of the disease, and the safety is good, the clinical treatment effect is remarkable.
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AIM:To investigate the efficacy and visual sensitivity of occlusion therapy combined training for children with ametropic amblyopia.METHODS:Totally 85 children (85 eyes) with anisometropic amblyopia treated in our hospital from January 2013 to January 2015 were selected.All patients were given occlusion therapy combined training.Statistical analysis of clinical efficacy and visual sensitivity changes were taken,and the changes of visual acuity,AULCSF,S Frmax were analyzed.RESULTS:The visual acuity after therapy was significantly better than that before treatment (1.12±0.29 vs0.45±0.25,P＜0.01);AULCSF,Smax and Frmax all increased,the difference between the two groups was statistically significant (P＜ 0.05).The sensitivity of the same spatial frequency was significantly higher than that before treatment,the difference was statistically significant (P ＜ 0.05),and the contrast sensitivity decreased gradually with the increase of spatial frequency.There were statistical differences in the total effective rate of different refractive degrees after treatment (P=0.001).Mild group and moderate group had no significant difference on the total clinical efficiency difference (x2=3.091,P=0.079);between mild group and severe group total effective rate was significantly different (x2 =11.471,P =0.001);the moderate and severe groups total clinical efficiency were no significantly different (x2 =3.359,P=0.067).In addition,the total efficiency rate of wearing glasses under the age of 6 was significantly higher than that after 6 years old (95％ vs 77％),statistical difference between the two groups was significant (P＜0.05).CONCLUSION:Masking therapy combined with comprehensive training,in the treatment of children with ametropic amblyopia,and wearing a corrective spectacles,is desirable,especially for children under 7 years of age.
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Se realizó una investigación analítica y prospectiva, de casos y controles, de los niños con glaucoma o estrabismo, o ambos, atendidos en la consulta de Oftalmología del Hospital Infantil Sur de Santiago de Cuba, de enero a junio del 2011, a fin de evaluar la percepción visual del movimiento coherente en ellos. El grupo de casos incluyó 72 pacientes escogidos de forma aleatoria, y el de controles, igual cantidad de integrantes que presentaban toda su capacidad visual. Se determinó que los niños con afecciones en la visión cometían más errores, omisiones y menos aciertos, además de ser menos rápidos en la solución de los ensayos orientados, pues tuvieron mayor tiempo de reacción para ejecutarlos.
A prospective analytic case-control study was carried out in children with glaucoma or strabismus or both, treated at the Department of Ophthalmology of the Southern Children Hospital in Santiago de Cuba, from January to June 2011, with the purpose of assessing the visual perception of coherent motion in them. The case group included 72 randomly selected patients, and control group with the same number of members who had all their vision. It was determined that children with visual disorders made more errors, omissions and fewer hits, besides being less rapid in solving oriented tests, as they had longer reaction time to do them.
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Histology and morphometry of the eye in the freshwater Paracheirodon axelrodi (Characiformes: Characidae). The visual system of Teleost fishes has a wide range of adaptations. The eye has suffered modifications, mainly towards better sensitivity and visual resolution according to specific environmental conditions. In that way, this organ is so important for survival. In spite of being the most commercialized Orinoquía species, and one of the most important ornamental fish worldwide, there are almost no studies on the communication systems of P. axelrodi (including vision). We studied the eye in ten individuals of P. axelrodi, with a mean total length of 2.7 cm (SD= 0.2, n= 20). We measured eye relative size (TRO) after sacrifice. Heads were processed for hematoxylin-eosin, and 8 μm thick sections were obtained. Images were digitalized for histological identification and morphometrics. The relation between TRO and body length was 9.8% (SD= 1.1, n= 20); lens was spherical with a relative size of 64.3% (SD= 4.9, n= 20). Rete mirabilis choroid was composed mainly by capillaries, while sclera was composed of cartilaginous tissue. Retina with eight layers and two membranes. An areae centrales was observed in the posterior retina. Iris covered by a simple cubic epithelium. Cornea of endothelial tissue with two membranes. Pupil almost circular, with a naso-caudal elongation. Measures of retina thickness were as follows: lateral retina 144.5 μm (SD= 5.4, n= 20), temporal retina 210.4 μm (SD= 14.8, n= 20). Lens measurements were: dorso- ventral 759.6 μm (SD= 31.7, n= 20), antero-posterior 763.4 μm (SD= 30.7, n= 20). Cornea thickness was 27.6 μm (SD= 4.3, n= 20); iris thickness was 18.9 μm (SD= 1.9, n= 20); rete mirabilis choroid 22.2 μm (SD= 3.2, n= 20) and sclera: 15.9 μm (SD= 1.2, n= 20). This species has a typical Teleost eye conformation. The retina was thicker in the posterior area, probably related to the presence of neuron groups. This modification allows for a better sharpness and visual resolution. The TRO, areae centrales in the retina, and thin cornea, suggests the need of a well developed visual system resulting from a predatory diet. Rev. Biol. Trop. 57 (4): 1107-1118. Epub 2009 December 01.
El pez dulceacuícola P. axelrodi es de gran importancia comercial en la Orinoquía Colombiana y a nivel mundial, pero carece de estudios acerca de su visión. Se utilizaron diez individuos, con longitud total promedio de 2.7 cm (SD= 0.2, n= 20). Se realizaron cortes a 8 μm y se tiρeron con H-E. El tamaρo relativo del ojo es 9.8% (SD= 1.1, n= 20); el cristalino tiene un tamaρo relativo de 64.3% (SD= 4.9, n=20). Una esclerótica con tejido cartilaginoso. La retina está constituida por ocho capas y dos membranas, hay areae centrales en la zona posterior, por lo tanto tiene mayor espesor que la zona lateral. El espesor promedio de las estructuras es: retina lateral: 144.5 μm (SD= 5.4, n= 20), retina temporal: 210.4 μm (SD= 14.8, n= 20); cristalino (esfιrico): dorso-ventral 759.6 μm (SD= 31.7, n= 20) y antero- posterior 763.4 μm (SD= 30.7, n= 20) y cσrnea: 27.6 μm (SD= 4.3, n= 20). El tamaρo relativo del ojo, relacionado con la presencia de areae centrales y una córnea delgada, muestra las necesidades visuales del neón cardenal (cazador) para adaptarse al hábitat, lo que hace necesario tener un sistema visual desarrollado que le permita tener mejor sensibilidad y resolución visual.