ABSTRACT
Vladimiriae Radix is a Tibetan medicine with national characteristics, which contains compounds such as sesquiterpene, lignin, and volatile oil. Pharmacological studies indicated that the sesquiterpenes in Vladimiriae Radix had good activity in the digestive diseases, liver and gallbladder pain, anti-inflammatory and antispasmodic. This review mainly integrated domestic and foreign researches, and summarized the advances in the chemical constituents and the pharmacological activities of Vladimiriae Radix systematically. It provides references and scientific basis for pharmacological study and utilization of Vladimiriae Radix.
ABSTRACT
Objective: To analyze the absorption difference of the principal active components in Vladimiriae Radix, costunolide and dehydrocostuslactone, between the crude Vladimiriae Radix (CVR) and roasting-processed Vladimiriae Radix (RPVR), in stomach, small intestine, and colon in rats. Methods: The in situ perfusion models of stomach, small intestine, and colon in rats were established, the contents of costunolide, dehydrocostuslactone, and phenol red were determined using HPLC-UV method, and the parameters of absorption kinetics of the test object in stomach, small intestine, and colon were obtained. Results: The absorption percentage per hour of costunolide and dehydrocostuslactone in CVR was higher than that in RPVR in stomach and small intestine of rats (P < 0.05). However, the absorption percentage per hour of costunolide and dehydrocos in RPVR was higher than that in CVR in colon of rats (P < 0.01). Conclusion: The absorption rate of cstunolide and dehydrocostuslactone in CVR is higher than that in PVR sample in colon of rats.
ABSTRACT
Objective: To compare the metabolic profiling of Vladimiriae Radix (VR) before and after simmer processing and to screen out the characteristic constituents leading to some differences. Methods: The chromatogram data sets of the processed and unprocessed VR were obtained by HPLC-UV analysis; The metabolic profiling differences of VR before and after processing were compared by principal component analysis, partial least square-discriminant analysis, and hierarchical cluster analysis, then the characteristic constituents were screened out. Results: The metabolic profilings between processed and unprocessed VR were apparently different, and the data showed seven constituents among them mainly made the quality difference, including costunolide and dehydrocostus lactone. Conclusion: The processed and unprocessed VR have the significant differences on the metabolic profiling.