Probable Mode of Action of Panktiprasoonadi Ghritham in Vishaja Vrana Based on Analysis of Rasa Panchaka of Ingredients

Traditional management of Visha Chikitsa involves many practices that are yet to be explored. Keraleeya Visha Chikitsa Granthas possess abundant knowledge of practically used formulations in treatment of Visha as well as its complications. Vishaja Vrana can be considered as Aganthuja Vrana which has to be managed at time to prevent its complications. Vrana hara Yogas with specific indication will be working more effectively in this condition. Visha Jyotsnika, a book written in Malayalam which explains about the treatment practices followed by Visha Vaidyas from time to time in a practicable approach. Mandali Visha Chikitsa is explained in sixth chapter in detail along with various Vranahara yogas. This article highlights about the probable mode of action of Panktiprasoonadi ghritham in Vishaja Vrana. Dasa Pushpa, the divya aushadhi for Visha being the main ingredient in this formulation along with the combination of other Vrana Ropana drugs like Kupilu, Haridra, Yastimadhu, Sariva etc as a Ghrita preparation will be an excellent option for managing Vishaja Vrana from its initial condition.

Conservative Management of Dushta Vrana (Chronic Ulcer) Through Ayurveda: A Case Study

Non-healing ulcers or Dushtavrana possess a great challenge to the doctors, as it is a very common problem presented by the patients. It is not only that the patient feels the pain and discomfort but the others who look at the patient, they also feel a lot of discomfort. It creates a very embarrassing situation for the patient in his day to day life. After trying for all the therapies eventually patient looks forward to Ayurvedic system of medicine with a very little ray of hope that here his ulcer may be healed. Fortunately only with the help of Ayurvedic medicines and without any sort of surgical intervention the patient get healed. This article presents the conservative management of non-healing ulcers or Dushtavrana which proved to be a miracle for the patients.

Review on Wound Healing Activity of Ropana Taila

Wound is a break in the integrity of the skin or tissue often, which may be associated with disruption of the structures and functions. Wound healing is a complex series of events that begin when an individual gets affected by a wound. It is a mechanism whereby the body attempts to re-establish the integrity of the injured part. In modern biomedical sciences, research on wound healing agents is one of the developing areas. Natural compounds are used in skin wound care from many years due to their therapeutic activities, including anti-inflammatory, antimicrobial, and cell-stimulating properties. Various herbs, oils and natural resources have been described in Ayurveda with wound healing properties. Acharya Sushruta has explained many drugs and formulations for the treatment of Vrana (wound). One such formulation named Ropana Taila has been described in Sushsruta Samhita for Wound healing. The present review article is undertaken to discuss about the wound healing activity of Ropana Taila

A Clinical Study of Haridradi Malhar (Ointment) in the Management of Nija Vrana

The Vrana (ulcer) is considered the core subject of Shalya tantra. Vata, Pitta and Kapha are aggravated by their respective causative factors that get lodged in the exterior of the body to give rise to Nija vrana (endogenous ulcer). Nija vrana are frequently encountered problem in present era produced commonly by the morbid Doshas of the body. In the present study, Haridradi taila (ointment) is selected which is mentioned by Acharya Sushruta in the context of Vrana. It contains Kasis, Kutaki, Jati, Haridra, Tagar, Agaru, Daruharidra, Deodaru, Priyangu and Lodhra. These ten ingredients possess the properties of both Shodhan and Ropan (cleaning and healing). It was used topically in the type of chronic wounds daily one time for 30 days or till the healing of the wound, whichever is earlier. It is a single-blind clinical study where 20 patients were selected and divided into two groups 10 patients each. Experimental group patients wounds were treated with a dressing having Haridradi ointment and control group patients' wounds were treated with Framycetin ointment and dry gauze bandaging. It reduces pain, burning sensation, itching, decreases discharge, oedema and helps in gradual improvement in floor and granulation tissues as compared to control group. Nija vrana (chronic wounds) management with Ayurvedic remedies is one of the major areas of research, hence it can be speculated that Haridradi ointment possesses sufficient efficacy in Vrana shodhan and Vrana ropan (cleaning and healing of the wound) without creating any adverse effect

Review Study Of Potential Wound Healing Properties Of Panchavalkala

Break in the continuity of skin is known as wound. Nature has given tremendous natural capacities to human being to heal wounds. The processes of healing get activated immediately after the trauma and continue till the formation of a healthy scar in a sequential manner. This normal response gets disrupted in different conditions like slough, infection, blood supply to the area, presence of foreign bodies, unhygienic treatments, and general factors like nutritional conditions, presence of systemic diseases etc. Wound healing process can be facilitated by natural products with medicinal properties. Many studies on the wound healing properties of natural products with anti-inflammatory, antioxidant, antibacterial and pro-collagen synthesis actions have been conducted. Panchavalkala was studied in different forms like gel, decoction, ointment, sanitizer, Ghanasatwa, Taila, Ghrita and cream. In all forms it has proved its efficiency for wound healing. This article is aimed to review and summarized the preclinical and clinical research studies conducted on wound healing activities of Panchavalkal in the different forms like extract, gel, ointment, douche, Kwath etc. Exciting clinical and preclinical studies found with very good healing property of Panchavalkala.

Clinical Comparative Study On The Efficacy Of Ghonta Phaladi Varti And Aragvadhadi Varti In The Management Of Nadi Vrana W.s.r. Sinus

Clinically Nadi Vrana forms if abscess is avoid or treated improperly and ineffectively with post-operative complications and complaints of recurrences in most of the cases by the line of treatment adopted by modern surgeons. In spite of tremendous progress in the field of modern surgery, still there or greatly analyzed chances of recurrence are noticed. Objectives: The study is aimed to know the comparative efficacy of Ghonta Phaladi Varti and Aragvadhadi Varti in the management of Nadi Vrana. Method: Total 30 patients diagnosed to be suffering from Nadi Vrana (Sinus) were selected randomly. These were divided into two groups A and B containing 15 patients in each. Group A patients were treated with Ghonta Phaladi Varti application and group B patients were treated with Aragvadhadi Varti application. Result: Comparative statistical analysis of both groups A Ghonta Phaladi Varti and B Aragvadhadi Varti denotes insignificant difference with respect to parameters such as length of the tract, discharge, surrounding skin, tenderness, temperature, pain, burning sensation and itching. But group A is more effective than group B. Interpretation: It is recommended to conduct clinical trial on large sample size may be with some acceptable modifications in drug, dose and durations which may give more beneficial result. Conclusion: When two groups were compared more improvement was seen in patients treated with Ghonta Phaladi Varti than Aragvadhadi Varti.

A Comparative Clinical Study On Application Of Yashada Bhasma Lepa And Jatyadi Ghrita In The Management Of Dushta Vrana W.s.r. Diabetic Ulcer

Introduction: Wounds and their management are fundamental to the practice of surgery. In surgery of trauma, wound is frequently a primary pathology. In elective surgery, it is through the wound that access is obtained to deal with the underlying pathology. In both situations surgeon’s task is to minimize the adverse effects of wound, remove or repair damaged structures and harness the process of wound healing to restore function. Objectives: The study is aimed to know the comparative efficacy of Yashada Bhasma Lepa and Jatyadi Ghrita in the management of Dushta Vrana. Method: Clinically diagnosed 30 patients of Dushta Vrana were randomly divided into two groups, each group consisting of 15 Patients. First (A group) is treated by Yashada Bhasma Lepa and second (B group) is treated by Jatyadi Ghrita for 21 days. Result: On the basis of assessment criteria and on the overall result of treatment the patients of Yashada Bhasma Lepa group showed better relief when compared to Jatyadi Ghrita. Interpretation: Yashada Bhasma Lepa having the properties of Tikta, Kashaya, Katu, Rasa predominance thus had action of Kapha Pitta Shamana, Netra Roga, Pandu, Bahumootra Roga, Kasa, Swasa, Rajayakshma, Ratrisweda, Vranasrava Avarodaka,Prameha, Sankochakara.etc. Thus this help for Shodhanaand Ropana. Conclusion: Yashada Bhasma Lepa has provided better relief in maximum signs and symptoms of the patients of Dushta Vrana, in comparison to Jatyadi Ghrita. Its overall effects were also better in comparison to Yashada Bhasma Lepawith Jatyadi Ghrita and dressing reduces the infection.

Screening Of Wound Healing Activity Of Madayantika (lawsonia Inermis Linn.) In Albino Wistar Rats

Madayantika (Lawsonia inermis Linn.) is a miracle medicinal plant used in the treatment of various skin diseases especially in wound healing activity in the Indian system of medicine. Aim and Objective: The objective of the study presented in this article was to evaluate the wound healing potential of aqueous extract. The models usually used for evaluation of wound healing activity are Excision wound model, Incision Wound Model and Dead Space model. Among those excisions wound model is selected for the study. Healthy wistar strain Albino rats of either sex weighing 150-200gm were used for the study. Animals are acclimatized in a laboratory and then it were anaesthetized and then dorsal surface of rats were shaved to about an area of 500mm2 and then it was cut carefully with sterilized forceps and left undressed for open environment, then extracts of test drugs, Scaffolds containing aqueous extract and standard drug were applied and then observed and noted. Results: The extract of Madayantika (Lawsonia inermis Linn.) treated wounds were found to epithelize faster and rate of wound contraction was significantly (p<0.0001) increased as compared to control group (p< 0.01). The extract treated animals showed from 502 �364 to 25.1�252 reduction in wound area when compared with control groups from 502� 0.538 to 40.71� 0.166. Conclusion: Madayantika (Lawsonia inermis Linn.) possess significant wound healing effect which may beneficial in treating wounds. This drug showed extremely significant results in wound healing activity.

Formulation And Physico-chemical Characterisation Of Ksharaplota Dressing For Vrana Chikitsa

Good quality of wound healing is a difficult task to the clinicians in ancient time and even in present time though. Wound healing is a defense mechanism of our body to prevent and fight against infection. In Health sciences, wound healing formulations are practiced with their own advantage and disadvantages. Ayurveda is a divine science of medicine where there are so many pieces of diamonds available for management of Vrana without any complication. Our Acharyas broadly described about treatment principles of wound management and classified the drugs related to Vranashodhana and Vranaropana. As per text we are well known about the wider approach of Acharya Sushruta in relation to Vrana and its management. They have mentioned various dressing materials for wound care it comprises Pichu, Plots, Kawalika, etc. Among these Plota is much better because we can use it for both purposes i.e. to clean as well as to cover the wound. Ksharaplota (medicated gauze) is an innovative and newer concept used for management of Infected and chronic Wounds and ulcers. This Ksharaplota is a herbo-chemical compound and prepared with the help of Snuhikshira (milk of Euphorbia neriifolia Linn.), Apamargakshara (ash of Achyranthes aspera L.) and Haridra (Curcuma longa L.). A single coating of the above drugs were given to the Plota (gauze). It can be used in number of open wounds and ulcers. This Ksharaplota was prepared similarly with basic concept of Ksharsutra preparation. The Aim of this study was to formulate Ksharaplota dressing and to do the physico-chemical analysis of the Ksharaplota. The proved that pharmaceutical processing of the raw drugs imparts characteristic property to the formulation were evident by the physicochemical analysis of the Ksharaplota. The method of formulation of Ksharaplota holds good even for today’s era and can be considered as standard protocol for Vrana Shodhana and Ropana in Dushta Vrana Chikitsa.

A Review Of Burn Injury And Its Management In Ayurvedic System Of Medicine: A Comparative Study For Local Wound Care

Burn injury has been associated with the evolution of human civilization since time immemorial. Burn injuries has always been faced by human in different era with change of mode injury from past to present. Unlike other diseases the basics of burn injury remains more or less same. The basic concepts and principles of management of burn injury is described in Ayurveda are very much relevant and useful in this era of modern surgery. Sushrut Samhita, the treasure of surgical knowledge of ancient Indian civilization, is a rich source of information regarding burn injury, assessment and management. Most of the other scholars of Ayurveda follow the basic concept of Sushrut Samhita. All the Brihatrayee (three greater treatises) and Laghu trayee (three lesser treatises) and other relevant textbooks of Ayurveda studied to search the different data regarding Dagdha vrana (burn injury), etiological description, gradation, different principles of treatment and available dressing material. The collected data evaluated scientifically to make it usable in the modern era of surgery. The result shows that although there is change in mode of burn injury found in modern era, the basic principles of etiology, classification, management and use of dressing material are almost the same as standard burn wound management of contemporary medical science. So the benefits of Ayurveda can be inducted in modern era of burn care.

Pharmaceutical Development & Anti-microbial Study (in Vitro) Of Tankanamruta Malahar W.s.r. To Rasa Tarangini

Tankanâ which is among the â˜Kshar traya’ mentioned in “Kshar trik vidnyaniya trayodasha taranaga†of Acharya Sadananda Sharma virachit ‘Rasa tarangini’. Tankan i.e., Borax (Na2B4O7 10H2O) is composed of boric acid & soda. It is a salt of tetra Boric acid, an important compound of Boron, which is also known as sodium biborate. Other Rasa Vaidyas also have included “Tankan†under the groups of Ksharatraya, Ksharapanchaka, Dravaka gana, Mitra panchaka etc. The present study was conducted to develop “Tankanamruta malahar†(pharmaceutically & to study its antimicrobial activity (In vitro). “Tankanamruta malahar†is a good combination of herbo-mineral preparation, which is indicated in Dushta vrana shodhan chikitsa or infected wounds. Though this formulation is from Ayurvedic classical text but there is a need to develop the standard procedure of preparation as they have faster & accurate results than oral administration of drug, so by the fusion of modern instruments & traditional methods of manufacturing procedures we have tried to make “Tankanamruta malahar†which contains Shuddha Tankan bhasma, Siktha taila, Sarji kshar, Shuddha pushpa kasis & Pipal twak kshar. Standardization describes all measures taken during manufacturing process like Shodhan, Maran, Kshar nirman & Siktha taila preparation etc & quality control leads to reproducible quality of particular product & in vitro study was performed to evaluate its anti-microbial activity against selected pathogens.

Katupila (Securinega leucopyrus) as a potential option for diabetic wound management.

In acute and chronic wounds, Katupila (Securinega leucopyrus) (Willd.) Muell is a commonly used folklore remedy in Sri Lanka and Saurashtra region of India. We report a case of Madhumehajanya Dushta Vrana (chronic diabetic wound) that was treated with local application of S. leucopyrus in paste form once daily. Wound healed within a month with normal pigmentation and minimal scar. This case also demonstrated possible antimicrobial potential in the treatment of Dushta Vrana.

Carmakila: An effective management by kshara karma.

Epidermal nevi are hamartomas that are characterized by hyperplasia of epidermis and adnexal structures. These nevi may be classifi ed into a number of distinct variants, which are based on clinical morphology, extent of involvement, and the predominant epidermal structure in the lesion. Variants include verrucous epidermal nevus, nevus sebaceous, nevus comedonicus, eccrine nevus, apocrine nevus, Becker’s nevus, and white sponge nevus. A 22-year-old girl approached us with complaints of blackish-colored hard growth, increasing in size over the right post-auricular region since 5 years. Ksharakarma is a procedure that involves the most important surgical, para-surgical, and critical-care procedures like incision, excision, scraping, and hemostatic locally (pratisaraneeya) and generally (panneya). Pratisaraneeya kshara is prepared with herbo-mineral medicines having an average pH of 13, possessing penetrating, corrosive, scraping, and healing properties, and are evidently indicated for external application in charmakīla. For the present case, kshara karma was preferred for application as the lesion was bigger in size and the results were appreciable clinically.