Vulvar melanoma with multisystemic metastases: A rare case presentation

Malignant melanoma is the second most common vulvar malignancy which occurs in elderly females. In advanced stages of the disease, distant metastases can occur to any organ; hence, comprehensive radiological evaluation is necessary. We report a case of a 45-year-old female who presented with progressively increasing growth over the vulva for 6 months. On detailed clinical, pathological, and radiological workup, multiple metastases were found in the brain, liver, pancreas, peritoneum, lungs, and pleura. The final diagnosis of vulvar melanoma with multisystemic metastases was made after the histopathological examination

Melanoma vulvar en una paciente de la tercera edad / Vulvar melanoma in a third age patient

Se describe el caso clínico de una paciente de 62 años de edad, negra, atendida en el Hospital Oncológico Docente Provincial Conrado Benítez García de Santiago de Cuba, por presentar aumento de volumen en el labio menor que comenzó a doler. Se realizó biopsia excisional, cuyo resultado reveló un melanoma vulvar. Se remitió a la consulta de Ginecología oncológica donde se le indicó tratamiento con quimioterapia e inmunoterapia por ser un tumor no operable. Se le administraron 4 ciclos de quimioterapia con buena respuesta y estabilidad. Se continuó su atención en consulta de seguimiento.

The case report of a black-skinned 62 years female patient assisted in Conrado Benítez García Teaching Provincial Oncological Hospital in Santiago de Cuba is described due to an increase of volume in the outer lip that began to hurt. A excisional biopsy was carried out which result revealed a vulvar melanoma. She was referred to the Oncological gynecology service where she was indicated treatment with chemotherapy and immunotherapy for being a non-surgical tumor. Four chemotherapy cycles were administered with good response and stability. Her care continued through follow-up.

Two Cases of Vulvar Melanoma / 대한피부과학회지

Vulvar melanoma is the second most common vulvar malignancy but occupies less than 1% of all melanomas. It occurs predominantly in the fifth to eighth decades of life and the most common presentation is a vulvar mass or lump, although pruritus and bleeding are also frequent. Vulvar melanoma usually shows deep infiltratition earlier than cutaneous melanoma due to abundant lymphatic channels and blood vascularization, and so its prognosis is mostly poor. Depth of invasion has been reported as the single most important indicator of prognosis. Previously the treatment of choice for vulvar melanoma has been radical vulvectomy with bilateral inguinofemoral lymphadenectomy but recently there have been reports suggesting that a comparable survival rate may be achieved by local wide excision. We herein report two cases of vulvar melanoma presented in labia minora with a brief review of the literature.

Two Cases of Vulvar Malignant Melanoma / 대한산부인과학회잡지

Malignant melanoma may show a predisposition for vulvar skin. Although 37% of all melanomas in women affect the vulva, the skin in this area accounts for only 12% of the total surface area of body. Malignant melanoma of the vulva presented as polypoid tumours in 35% of patients. The most common sites of disease were the clitoral area and the labia majora, which accounted for more than 60% of all lesions. Only 15% of tumours were located primarily in hair-bearing areas. Two women who were diagnosed vulvar melanoma in Uijongbu St. Mary's Hospital were evaluated. We reviewed their medical records. One woman underwent the radical vulvectomy with bilateral inguinal and femoral lymph node dissection, and the other underwent wide local excision with both inguinal lymph nodes dissection. We experienced 2 cases of vulvar melanoma, so we report it with a brief review of literature.