Ligustilide delays senescence of auditory cortex in mice by inhibiting ferritinophagy / 中国药理学通报

Aim To investigate the mechanism of ligu aged 2 months of the same strain were used as the constilide (LIG) in delaying the senescence of auditory trol (Ctrl) group. Auditory brainstem response test was cortex and treating central presbycusis. Methods used to detect the auditory threshold of mice before and Forty C57BL/6J mice aged 13 months were randomly di after treatment. Levels of serum MDA and activity of vided into ligustilide low-dose(L-LIG) group, ligustil serum SOD were detected to display the level of oxidative ide medium-dose (M-LIG) group, ligustilide high-dose stress. The pathological changes of auditory cortex were (H-LIG) group and aging (Age) group, and 10 mice observed by HE staining. Ferroptosis was observed by

Versatile Use of Mycobacterium indicus pranii (MIP) Vaccine

Mycobacterium indicus pranii (MIP) earlier known as Mw is a soil-borne, non-pathogenic, saprophytic and rapidly growing strain of mycobacteria. MIP is approved as a vaccine/ immunomodulator for various indications including mycobacterium infections like leprosy in humans. Its administration has resulted in satisfactory clinical improvement, accelerated bacillary clearance, and increased immune responses to Mycobacterium leprae antigens, thereby shortening the full recovery time of the patients. It also shares its antigens with M.tuberculosis. In the last decade, RCTs have been done establishing immunotherapeutic properties of MIP in the treatment of leprosy, tuberculosis, warts and experimently in leishmaniasis. Through its immune inducing and cytotoxic property, it has also proved beneficial for human use especially in treating lung cancer. The beneficial role of it is also being explored in breast, cervical, oral, liver, and bladder cancers. Various studies on MIP have shown that it has immune-modulating properties in humans. The curiosity of the human mind has led to it being tried in Covid treatment trials. The results have shown that administering MIP has lowered inflammatory markers in Covid 19 patients, promising us for it to be a potential treatment option. More RCTs with a larger sample size should be done to establish this. Cytokine storm seen in bacterial sepsis is also decreased with MIP administration. Considering the encouraging results in hastening recovery in various diseases it appears that MIP is perhaps not being exploited to its fullest potential

George W. Crile (1864-1943); excepcional cirurgião americano / George W. Crile (1864-1943); excepcional cirujano estadounidense / George W. Crile (1864-1943); exceptional American surgeon

George W. Crile (1864-1943); excepcional cirurgião americano, que serviu no Corpo Médico do Exército durante a Guerra Hispano-Americana. Durante a Primeira Guerra Mundial, foi diretor cirúrgico do American Ambulance Hospital em Neuilly, na França. Ajudou fundar o American College of Surgeons em 1913, foi membro e diretor não apenas dessa organização, mas também da American Medical Association, da American Surgical Association, da Royal Academy of Surgeons e da Royal Academy of Medicine (Reino Unido). Em 1921, foi cofundador da Cleveland Clinic em Cleveland, Ohio, EUA. Foi um importante médico cujas pesquisas e escritos incluíam choque cirúrgico, função glandular, pressão arterial e transfusões, neurose de guerra e os efeitos da cirurgia em tempos de guerra. Ele também foi um cirurgião extraordinário e prolífico que introduziu inovações no tratamento cirúrgico de muitas patologias. Embora sua pesquisa tenha sido publicada há muito tempo, suas contribuições para a medicina continuam sendo fundamentais para a prática clínica nas salas de cirurgia e unidades de terapia intensiva atuais.

George W. Crile (1864-1943) fue un excepcional cirujano estadounidense que sirvió en el Cuerpo Médico del Ejército durante la Guerra Hispanoamericana. Durante la Primera Guerra Mundial fue director quirúrgico del American Ambulance Hospital de Neuilly (Francia). Ayudó a fundar el Colegio Americano de Cirujanos en 1913 y fue miembro y director no sólo de esta organización, sino también de la Asociación Médica Americana, la Asociación Quirúrgica Americana, la Real Academia de Cirujanos y la Real Academia de Medicina (Reino Unido). En 1921 fue cofundador de la Cleveland Clinic de Cleveland (Ohio, EE.UU.). Fue un importante médico cuyas investigaciones y escritos abarcaron el shock quirúrgico, la función glandular, la presión arterial y las transfusiones, la neurosis de guerra y los efectos de la cirugía en tiempos de guerra. También fue un cirujano extraordinario y prolífico que introdujo innovaciones en el tratamiento quirúrgico de muchas patologías. Aunque sus investigaciones se publicaron hace mucho tiempo, sus aportaciones a la medicina siguen siendo fundamentales para la práctica clínica en los quirófanos y unidades de cuidados intensivos actuales.

George W. Crile (1864-1943) was an exceptional American surgeon who served in the Army Medical Corps during the Spanish-American War. During the First World War, he was surgical director of the American Ambulance Hospital in Neuilly, France. He helped found the American College of Surgeons in 1913 and was a member and director not only of this organization, but also of the American Medical Association, the American Surgical Association, the Royal Academy of Surgeons and the Royal Academy of Medicine (UK). In 1921, he co-founded the Cleveland Clinic in Cleveland, Ohio, USA. He was an important physician whose research and writings included surgical shock, glandular function, blood pressure and transfusions, war neurosis and the effects of wartime surgery. He was also an extraordinary and prolific surgeon who introduced innovations in the surgical treatment of many pathologies. Although his research was published long ago, his contributions to medicine remain fundamental to clinical practice in today's operating rooms and intensive care units.

Agreement of corneal high-order aberrations measured by three wavefront aberrometers in myopic adults / 国际眼科杂志(Guoji Yanke Zazhi)

AIM:To evaluate the agreement of corneal high-order aberrations from Topcon KR-1W, i.Profiler and OPD-Scan Ⅲ wavefront aberrometers in myopic adults.METHODS:A prospective clinical study. A total of 92 adult patients(92 eyes)with myopia in the department of optometry, the People's Hospital of Guangxi Zhuang Autonomous Region from June to August 2022 were enrolled. The third-order and fourth-order corneal aberrations at the pupil diameter of 4 and 6mm were measured by Topcon KR-1W, i.Profiler, and OPD-Scan Ⅲ, respectively. The difference and agreement of the three aberrometers were evaluated.RESULTS: The measurements at 6mm pupil diameter were all greater than those at 4mm pupil diameter. Although there were no statistical differences in the measurements of Z-44、Z-24 by the three aberrometers at 4 pupil diameter(P>0.05), there were statistical differences in other measurements(P<0.05). The aberration results measured by the three aberrometers were statistically different at the 6mm pupil diameter(P<0.05). The 95% limit of agreement(95%LoA)of the measurements of higher-order aberration, including the third-order aberrations at 4mm pupil diameter and the third-order and fourth-order aberrations at 6mm pupil diameter(except for the Z-24)were greater than 0.1μm. The concordance correlation coefficient(Pc)was lower than 0.90, indicating a poor consistency. The correlation coefficients of corneal higher-order aberrations were significantly different among the three aberrometers at 4 and 6mm pupil diameter(r4mm=0.215～0.805, P4mm<0.05; r6mm=0.561～0.916, P6mm<0.001).CONCLUSION:There were significant differences in the measurements of the third- and fourth-order corneal aberrations at 4 and 6mm pupil diameter among Topcon KR-1W, i.Profiler, and OPD-Scan Ⅲ, and the agreements were poor, so they are not interchangeably in clinical applications.

The effect of the extracellular vesicle loaded polylactic acid microspheres in promoting hepatocyte proliferation / 中国热带医学

@#Abstract: Objective　To prepare a microparticle delivery system that regulates the release rate of extracellular vesicles (EVs), and to exert long-term enhancement of liver cell proliferation after only one intervention. Methods EVs was extracted by differential centrifugation. The structure of the EVs was observed by transmission electron microscopy and the membrane marker protein of EVs was detected by Western blotting. EVs-PLA microspheres with "core-shell" structure were prepared by emulsion-solvent evaporation method. Scanning and transmission electron microscopy were used to detect the morphology of EVs-PLA microspheres and EVs. The release test detected the release behavior of EVs in EVs-PLA microspheres. Scanning electron microscopy was used to detect the morphological changes of EVs-PLA microspheres at 8 weeks of release. EVs-PLA microspheres were co-cultured with hepatocytes, and Phalloidin/DAPI staining was used to observe the cell morphology and evaluate the cytotoxicity of the microspheres. CCK8-test was used to evaluate the cell proliferation activity. Western blot analysis was used to detect extracellular vesicles membrane marker protein expression. Results Comparing the ability of hepatocyte proliferation in the group treated with EVs-PLA microspheres and the control group, it was found that EVs-PLA microspheres did not cause cell apoptosis and mutation in cell structure, had biocompatibility and no cytotoxicity. The EVs-PLA microspheres with "core-shell" structure regulated the release behavior of EVs, which can continuously release EVs, exerting a continuous biological role in promoting hepatocyte proliferation after a single intervention. Conclusions The EVs-PLA microspheres can control-release EVs and promote hepatocyte proliferation continuously after a single intervention, providing a reference for further exploration of EVs-loaded delivery systems in promoting liver regeneration.

Research on the Communication Strategies for Shaanxi Traditional Chinese Medicine Culture Based on the "5W" Model / 中国医学伦理学

Traditional Chinese medicine (TCM) is a treasure of ancient Chinese science and a key to unlocking the rich heritage of Chinese civilization. Report of the 20th National Congress of the Communist Party of China and the important speech by General Secretary Xi Jinping at the symposium on cultural inheritance and development provide scientific guidance for accelerating the dissemination of TCM culture in Shaanxi. Starting from the value implications of strengthening the dissemination of TCM in Shaanxi, Taking Harold Lasswell’s "5W" theory as the analytical framework and the problems of weak leadership of communication subjects, insufficient scientific content, low flexibility of communication channels, weak targeting of communication audiences, and insufficient integration of communication effects in the dissemination process of TCM culture in Shaanxi, this paper proposed strategies for the dissemination of Shaanxi TCM culture from five aspects, including strengthening dissemination subjects, optimizing communication content, diversifying communication channels, segmenting communication audiences, and enhancing communication effectiveness.

Construction of continuous nursing program for children with congenital imperforate anus based on 5W1H analysis / 中国实用护理杂志

Objective:Based on the framework of 5W1H analysis, to establish the continuous nursing project by delphi expert consultation method for children with congenital imperforate anus after discharge.Methods:This study is observational. Through the literature review, qualitative interview and group discussion to establish the expert correspondence questionnaire from April 2021 to March 2022. Delphi consultation was applied to experts for two rounds of expert consultation, to evaluate the initiative, authority and coordination of expert opinions.Results:Two rounds of expert consultation were carried out with 20 experts.The response rates of two rounds of expert questionnaires were 19/20 and 20/20 respectively, the expert authority coefficients were 0.873 and 0.893 respectively, and the Kendall′s coefficients were 0.311 and 0.405 respectively. The coordination of expert opinions was statistically significant ( P<0.05); After two rounds of expert consultation, it was finally determined that the continuing care plan for children with anal atresia included three first-level indicators (composition and responsibilities of continuing care personnel, implementation methods of continuing care, and implementation content of continuing care), 23 second-level indicators, and 46 third-level indicators. Conclusions:This study have high enthusiasm and authority of experts, and concentrated expert opinions on various indicators. The results are reliable, scientific and comprehensive, which will provide a basis for clinical medical staff to carry out the continuous nursing of children with congenital imperforate anus.

O cuidado infantil no pensamento winnicottiano à luz da Psicologia Psicanalítica Concreta / Infant care in winnicottian thought in the light of Concrete Psychoanalytic Psychology / El cuidado infantil en el pensamiento winnicottiano a la luz de la Psicología Psicoanalítica Concreta

Este texto objetiva demonstrar e debater, à luz da psicologia psicanalítica concreta, uma contradição vigente no pensamento winnicottiano, expressa pela coexistência de duas visões acerca do cuidado infantil e da maternidade. Organiza-se em três seções. Na primeira, apresenta a psicologia psicanalítica concreta como referencial teórico. Na segunda, explicita e detalha a contradição do pensamento winnicottiano sobre cuidado infantil e maternidade. Na terceira, articula uma leitura do texto winnicottiano a partir da psicologia psicanalítica concreta, situando-a como convergente com a ontologia do ser social de Lukács. Por fim, indica a possibilidade de conhecimentos psicanalíticos colocarem-se a serviço de iniciativas a favor de transformações sociais que buscam superação de visões essencialistas sobre a maternidade.

The aim of this article is to demonstrate and debate, in the light of concrete psychoanalytic psychology, a current contradiction in winnicottian thought expressed by the coexistence of two visions over infant care and motherhood. The reflections on the matter are shown in three sections. Firstly, concrete psychoanalytic psychology as a theoretical framework is set. Secondly, explanation and details on the contradiction of winnicottian thinking about infant care and motherhood are discussed. Thirdly, the articulation on a view of a winnicottian's text from the point of view of concrete psychoanalytic psychology placing it as convergent with Lukács's ontology of social being is presented. Finally, the possibility of psychoanalytic knowledge being put at the service of initiatives in favor of social transformations seeking to overcome essentialist views on motherhood is indicated.

Este texto pretende demostrar y debatir, bajo la égida de la psicología psicoanalítica concreta, una contradicción imperante en el pensamiento de Winnicott, expresada por la coexistencia de dos visiones sobre el cuidado infantil y la maternidad. Está organizado en tres secciones. En la primera, presenta la psicología psicoanalítica concreta como marco teórico. En la segunda, explica y detalla la contradicción del pensamiento de Winnicott sobre el cuidado infantil y la maternidad. En la tercera, articula una lectura del texto winnicottiano basada en la psicología psicoanalítica concreta, situándolo como convergente con la ontología del ser social de Lukács. Finalmente, indica la posibilidad de poner el conocimiento psicoanalítico al servicio de iniciativas a favor de cambios sociales que busquen superar las visiones esencialistas sobre la maternidad.

Anti-Histone H3.3 G34W antibody is a sensitive and highly specific immunohistochemistry marker for the diagnosis of Giant cell tumor of bone. A validation based on analysis of 198 cases from a single centre in India

Context: The diagnosis of giant cell tumor of bone (GCTB) is difficult in small biopsies with unusual age of presentation, location, and extensive secondary changes. Most of the GCTBs harbor H3F3A G34W mutations with a subset of cases showing alternate G34V, G34R, and G34L mutations. Objectives: To analyze the expression of anti-histone H3.3G34W antibody in different cellular components of GCTB across different locations and presentations (including the unusual ones) and validate the utility of this antibody in the diagnosis of GCTB and differentiate it from the other osteoclast-like giant-cell-rich lesions. Design: Immunohistochemistry was performed using anti-histone H3.3G34W antibody in the diagnosed cases of GCTB (136 cases of GCTB from 133 patients, including two malignant GCTBs) and other giant cell-containing lesions (62 cases). The presence of unequivocal crisp nuclear staining was considered positive. Results: Immunohistochemistry revealed unequivocal nuclear positivity in the mononuclear cells in 87.3% of the cases of GCTB. Of these, most showed diffuse expression with moderate to strong intensity staining. The positive staining was restricted to the nuclei of mononuclear cells with the nuclei of osteoclastic giant cells being distinctly negative. In addition to conventional GCTBs, two cases each of multicentric and malignant GCTB showed positive staining. The other giant-cell containing lesions were distinctly negative. The present study showed a sensitivity of 87.3% with specificity and positive predictive value of 100%. Conclusion: The anti-histone G34W antibody is a highly sensitive and specific marker for the diagnosis of GCTB and differentiating it from its mimics. The positive staining is restricted to the mononuclear cell component of GCTB with sparing the osteoclastic giant cells further reiterating the fact that the mononuclear stromal cells are the true neoplastic component of GCTB.

A Review of Intubation Techniques in Anaesthetic Management of Temporomandibular Joint Ankylosis

Intubation of a patient with temporomandibular joint ankylosis is a challenge for every anaesthesiologist. Dependable anaesthetic technique is most desired by all anaesthesiologists. The purpose of the present article is to have a brief overview of temporomandibular joint ankylosis, its clinical features, management and to review literature demonstrating various intubation techniques available to an anaesthesiologist while managing patients with temporomandibular joint ankylosis.

Effects of age, gender, and anthropometric measurements on simple visual and auditory reaction time in healthy Indian adults

Background: Reaction time (RT) is the time interval between the application of a stimulus and voluntary motor response. Both visual and auditory RT reflect the cognitive function of an individual specially in spatial skills. Aims and Objective: This study aims to find the correlation between age, gender, and anthropometric measurements on simple visual and auditory RT. Material and Methods: One hundred healthy volunteers of both the genders (males 52 and females 48) aged between 18 and 50 years were recruited. RT is the elapsed time between the presentation of a stimulus and the subsequent behavioral response to occur. Subjects were presented with red light and 1000 Hz tone sound stimuli for both the genders. In RT there is coordination between the sensory and motor system occurs. The height, weight, waist circumference, and waist–hip ratio (WHR) were measured to observe the effects of these measurements on visual reaction time (VRT) and auditory reaction time (ART). Results: Statistical analysis of the data by one-way ANOVA with post hoc by Turkey HSD test was found significant with age, gender, and other anthropometric measurements WHR, BSA, and waist circumference) with P-value of 0.027, 0.067; 0.001, 0.125 and BMI 0.135 and 0.200; WHR 0.086 and 0.043; 0.050 and 0.064, respectively. Conclusion: As hypothesis suggests when BMI is increased, there is a significant increase in RT. The VRT and ART both are increased in female than male. RT increases as the age increases especially after 40 years. Objective: The objective of the study was to find the correlation between age, gender, and anthropometric measurements on simple visual and auditory RT.

A recusa aos laços: transmissão psíquica em "Os laços de família" de Clarice Lispector / El rechazo a los lazos: transmisión psíquica en "Os laços de familia" de Clarice Lispector / The refusal of bonds: psychic transmission in "Os laços de familia"by Clarice Lispector / Refus des liens: transmission psychique dans"Os laços de familia"par Clarice Lispector

O objetivo deste estudo teórico é refletir sobre os marcadores da transmissão psíquica no conto "Os laços de família", de Clarice Lispector, publicado originalmente em 1960. A interpretação ocorreu a partir da psicanálise winnicottiana em diálogo com a psicanálise dos vínculos sociais. A transmissão psíquica emerge como possibilidade de compreender a relação entre a protagonista, sua mãe e seu filho, destacando aspectos não apenas daquilo que é transmitido inconscientemente, mas da transmissão do adoecimento psíquico e da dificuldade em estabelecer vínculos. A transmissão mostra-se um caminho ao qual não se pode recusar. A potência da personagem Catarina reside na tentativa de remalhar, junto ao filho, o que fora comprometido em sua história desde as suas primeiras relações, reavendo falhas ambientais importantes e em direção à resiliência familiar

El objetivo de este estudio teórico es reflexionar sobre los marcadores de transmisión psíquica del cuento "Os laços de família"de Clarice Lispector, publicado originalmente en 1960. La interpretación se da desde el psicoanálisis winnicottiano en diálogo con el psicoanálisis vincular. La transmisión psíquica surge como una posibilidad para comprender la relación entre la protagonista, su madre y su hijo, destacando aspectos no solo de lo que se transmite inconscientemente, sino de la transmisión de la enfermedad psíquica y la dificultad para establecer vínculos. La transmisión es un camino que no se puede rechazar. La potencia del personaje de Catarina reside en el intento de compartir, con su hijo, lo comprometido en su historia desde sus primeras relaciones, reviviendo importantes fallas ambientales y hacia la resiliencia familiar

The aim of this theoretical study is to reflect on the markers of psychic transmission in Clarice Lispector's short story "Os laços de família", originally published in 1960. The interpretation took place from Winnicottian psychoanalysis in dialogue with the psychoanalysis of social bonds. Psychic transmission emerges as a possibility to understand the relationship between the protagonist, her mother and her child, highlighting aspects not only of what is unconsciously transmitted, but of the transmission of psychic illness and the difficulty in establishing bonds. Transmission is a path that cannot be refused. Catarina's character's power resides in the attempt to share, with her son, what had been compromised in her history since her first relationships, recapturing important environmental failures and towards family resilience

Le but de cette étude théorique est de réfléchir sur les marqueurs de la transmission psychique dans la nouvelle "Os laços de família" de Clarice Lispector, initialement publiée en 1960. L'interprétation est venue de la psychanalyse winnicottienne en dialogue avec la psychanalyse des liens sociaux. La transmission psychique apparaît comme une possibilité de comprendre la relation entre la protagoniste, sa mère et son enfant, mettant en évidence des aspects non seulement de ce qui est transmis inconsciemment, mais de la transmission de la maladie psychique et de la difficulté à établir des liens. La transmission est un chemin qui ne se refuse pas. La puissance du personnage de Catarina réside dans la tentative de partager, avec son fils, ce qui avait été compromis dans son histoire depuis ses premières relations, ravivant d'importants échecs environnementaux et vers la résilience familiale

Expression of BZW2 and IVD in hepatocellular carcinoma tissues and effect on prognosis of liver transplant recipients with hepatocellular carcinoma / 器官移植

Objective To investigate the expression levels of basic leucine zipper and W2 domain 2 (BZW2) and isovaleryl-CoA dehydrogenase (IVD) in hepatocellular carcinoma (HCC) and evaluate their effect on clinical prognosis of liver transplant recipients with HCC. Methods Pathological specimens and clinical data of 87 liver transplant recipients with HCC were collected and retrospectively analyzed. The recurrence and metastasis of HCC after liver transplantation were assessed. Immunohistochemical staining was used to detect the expression levels of BZW2 and IVD. The relationship between BZW2, IVD and clinicopathological parameters of HCC and their effect on postoperative recurrence and clinical prognosis of the recipients was analyzed. Results Among 87 recipients, 31 cases recurred with a recurrence rate of 36%. HCC recurred at postoperative 2-49 months and the median recurrence time was postoperative 7 months. Immunohistochemical staining demonstrated that the positive expression rate of BZW2 in the HCC tissues was significantly higher than that in normal liver tissues (76% vs. 30%), and the positive expression rate of IVD was significantly lower compared with that in normal liver tissues (51% vs. 69%) (both P < 0.01). BZW2 expression was significantly correlated with tumor diameter and tumor capsule (both P < 0.05), whereas IVD expression was significantly associated with tumor diameter, alpha-fetoprotein (AFP) level, tumor, node and metastasis (TNM) staging and whether vascular invasion was found or not (all P < 0.05). In the high BZW2 expression group, the cumulative recurrence rate of HCC was significantly higher and the cumulative survival rate was significantly lower than those in the low BZW2 expression group. In the low IVD expression group, the cumulative recurrence rate of HCC was significantly higher and the cumulative survival rate was significantly lower compared with those in the high IVD expression group (all P < 0.05). Conclusions The expression level of BZW2 protein is up-regulated, whereas that of IVD protein is down-regulated in the HCC tissues. Moreover, the cumulative recurrence rate of HCC is relatively high and the cumulative survival rate is relatively low in liver transplant recipients with high BZW2 expression and low IVD expression.

Identification of Weak D Type 1 in Rh Blood Group System and Discussion of Transfusion Strategy / 中国实验血液学杂志

OBJECTIVE@#To investigate the molecular mechanism of one patient with abnormal serological phenotype in RhD and discuss the transfusion strategy.@*METHODS@#The RhD variant sample was screened from a patient with IgM type anti-D antibody and further determined by three different sources of anti-D antibodies. Ten exons and the adjacent introns of the RHD gene were amplified, purified and sequenced. RhCE phenotypes and RHCE genotypes were detected.@*RESULTS@#The patient with Rh variant showed abnormal results of serological tests. The RHD gene sequence analysis showed that the RHD*01W.01 with a variation (c.809T>G, p.Val270Gly) in exon 6 of the RHD gene was found in the patient. The RhCE phenotype was CcEe. The genotyping results of RHCE were consistent with the serological typing results.@*CONCLUSION@#The Rh variant of the patient is RHD*01W.01, these findings indicate that RhD variants should be analyzed by molecular assays for the sake of safe transfusion.

Application value of squamous epithelial cells count, the white blood cells count and their ratio, and the bacteria count in the identification of female urine pollution / 中国医师进修杂志

Objective:To evaluate the significance of the white blood cells count (WBC), squamous epithelial cells count (SEC), bacteria count (BACT), the ratio of squamous epithelial cells count and white blood cells count (S/W), and the examination of leukocyte esterase by dry chemical method in urine contamination and infection.Methods:A total of 60 cases of urine infection and 60 cases of urine contamination in female outpatients and inpatients in Taizhou Hospital of Traditional Chinese Medicine from January to December 2020 were retrospectively analyzed. The five indexes of WBC, SEC, S/W, BACT and leucocyte esterase were compared between the two groups, WBC, SEC, S/W and BACT were analyzed by receiver operating characteristic (ROC).Results:By comparing the detection results of WBC, SEC, S/W, BACT and leukocyte esterase between the contaminated group and the infected group, using the nonparametric test of two independent samples, the results showed that the median level of WBC in the contaminating group specimens was lower than in the infected group: 58.00 (28.00, 102.00)/μl vs. 329.00 (145.00, 775.50)/μl, the difference was statistically significant ( Z = -7.03, P<0.01). The median level of SEC, S/W and BACT in the contaminated group were higher than those in the infected group: 43.00 (16.25, 73.75)/μl vs. 5.00 (3.00, 12.00)/μl, 0.620 (0.285, 1.209) vs. 0.018 (0.007, 0.037), 21.00 (6.25, 78.50)/μl vs. 204.50 (22.50, 816.75)/μl, and the differences were all statistically significant ( P<0.01). There was no significant difference in the results of leukocyte esterase between the two groups ( χ2 = 1.37, P = 0.24). The ROC curves of WBC, SEC, S/W, BACT were drawn, and the results showed that the four indexes had statistical significance in distinguishing pollution from infection ( P<0.01). Conclusions:Vaginal secretion will affect the detection of leukocyte esterase, WBC, squamous epithelial cells and bacteria in urine. WBC, SEC, S/W and BACT can be used as the differential diagnosis indexes of urine infection and urine contamination, and S/W can be selected as the differential diagnosis index of urine contamination.

Camganoids A and B, two new sesquiterpenes with different carbon skeletons isolated from fruits of Cinnamomum migao / 中草药·英文版

Objective: To isolate and identify the undescribed compounds from the fruits of Cinnamomum migao and evaluate its nitric oxide inhibition potential. Methods: The chromatographic techniques of silica gel, Sephadex, and HPLC were used for isolation and purification of the compounds, while HR-ESI-MS, 1D NMR, 2D NMR, ECD, and X-ray diffraction techniques were used to characterize and confirm the isolated compounds. Moreover, the anti-inflammatory activity of the isolated compounds was carried out to check inhibitory potential against the production of nitric oxide with RAW264.7 cells stimulated by LPS. Results: Camganoid A (1), a novel sesquiterpene possessing an unprecedented skeleton, and camganoid B (2), containing a unique eight-membered sesquiterpene moiety with a new carbon skeleton, were isolated and identified from the fruits of C. migao. The absolute configurations of 1 and 2 were confirmed by single crystal X-ray diffraction and electronic circular dichroism (ECD) calculations. Among these compounds, compound 1 exhibited potent inhibitory activity against the production of nitric oxide with IC

Interpretation of 2021 China Chest Pain Center Quality Control Report / 中国胸心血管外科临床杂志

@#The Medical Administration and Hospital Administration of the National Health Commission released the "2021 China Chest Pain Center Quality Control Report" in January 2022. This report analyzes the construction ratio of chest pain centers in the second-level and above medical institutions nationwide in 2021 and the construction of standard and basic chest pain centers, mainly from the way of coming to the hospital, symptom onset to first medical contact time, door to wire time, reperfusion therapy ratio, in-hospital mortality, proportion of discharges with medication recommended by the guidelines and average length and cost of hospital stay of ST-segment elevation myocardial infarction patients to comprehensively describe the current status of the construction of the national chest pain centers. This article interprets the report in detail by reviewing relevant literature.

Propiedades psicométricas de la Escala de Dependencia Específica del Cónyuge para Mujeres (EDEC-M) / Propriedades Psicométricas da Escala de Dependência Específica do Cônjuge para mulheres (EDEC-M) / Psychometric Properties of the Spouse Specific Dependency Scale for Women (SSDS-W)

Resumen El objetivo de esta investigación fue adaptar y validar la Escala de Dependencia Específica del Cónyuge para Mujeres (EDEC-M) para su uso en el contexto brasileño, que consta de 30 ítems. En el estudio 1, participaron 347 mujeres. Se obtuvo una estructura de tres dimensiones: apego ansioso (α = .88), dependencia emocional (α = .80) y dependencia exclusiva (α = .72), con consistencia interna satisfactoria. En el segundo estudio, participaron 325 mujeres, se probaron tres modelos de ecuaciones estructurales. Los resultados indicaron que el EDEC-M presentó mejores índices de ajuste en el modelo jerárquico de segundo orden: χ2 /df = 1.89; CFI = .95; TLI = .95; GFI = .95; RMSEA .05 y SRMR = 0.07. Este modelo fue apoyado por el Teoria de Respuesta al Item (TRI), que analizó una variación satisfactoria de la dificultad del ítem y permitió la construcción de un Mapa de ítems para la medición. Por lo tanto, el EDEC-M presentó propiedades psicométricas de validez de constructo para el contexto brasileño en mujeres.

Resumo O objetivo desta pesquisa foi adaptar e validar Escala de Dependência Específica do Cônjuge para Mulheres (EDEC-M) para utilização no contexto brasileiro, composto por 30 itens. No Estudo 1, contou-se com 347 mulheres. Obteve-se uma estrutura tri-dimensional: apego ansioso (α = 0,88), dependência emocional (α = 0,80) e dependência exclusiva (α = 0,72), com consistências internas satisfatórias. No segundo estudo, participaram 325 mulheres, foram testados três modelos de equações estruturais. Os resultados indicaram que a EDEC-M apresentou melhores índices de ajuste no modelo hierárquico de segunda ordem: χ2 /df = 1,89; CFI = 0,95; TLI = 0,95; GFI = 0,95; RMSEA 0,05 e SRMR = 0,07. Esse modelo foi suportado pela Teoria de Resposta ao Item (TRI), que analisou uma variação satisfatória de dificuldade dos itens e possibilitou a construção de um Mapa de Itens para a medida. Logo, a EDEC-M apresentou propriedades psicométricas de validade de construto para o contexto brasileiro em mulheres.

Abstract The aim of this research was to adapt and validate the Spouse Specific Dependency Scale for Women (SSDS-W) for use in the Brazilian context, which consists of 30 items. In study 1, 347 women participated. It was obtained a three- dimensional structure: anxiety attachment (α = .88), emotional dependence (α = .80) and exclusive dependence (α = .72), with satisfactory internal consistencies. In the second study, 325 women participated, and three structural equation models were tested. The results indicated that the EDEC-M presented better index adjustment in the second-order hierarchical model: χ2 /df = 1.89; CFI = .95; TLI = .95; GFI = .95; RMSEA .05 and SRMR = .07. This model was supported by Item Response Theory (IRT), which analyzed a satisfactory variation of the item difficulty and allowed the construction of an Item Map for the measure. Therefore, the EDEC-M presented satisfactory psychometric properties evidence of construct validity for the Brazilian context in women.

Abuso sexual infantil, trauma e depressão na vida adulta: um estudo de caso / Child sexual abuse, trauma and depression in adulthood: a case study

Este trabalho tem como objetivo verificar e analisar a associação entre os acontecimentos traumáticos na infância - em especial o abuso sexual - e o transtorno depressivo. Fundamenta-se principalmente nos pressupostos psicanalíticos de Winnicott, Ferenczi e Masud Khan. Trata-se de um estudo de caso de uma mulher de sessenta e dois anos que apresentava, no processo psicoterápico, acentuado quadro depressivo e severos sentimentos inconscientes de culpa. As reflexões clínicas derivadas dos questionamentos teórico-práticos trazidos pelo atendimento da paciente e a melhora de sua sintomatologia com a psicoterapia motivaram a elaboração deste artigo. Os resultados indicam que os múltiplos e crônicos traumas intrafamiliares ocorridos na infância foram fatores importantes para o quadro de depressão da paciente, levando a crer que o trauma decorrente do abuso sexual pode ser decisivo para a futura eclosão dessa patologia.

This work aims to verify and analyze the association between traumatic events in childhood - especially sexual abuse - and depressive disorder. It is based mainly on the psychoanalytic assumptions of Winnicott, Ferenczi and Masud Khan. This is a case study of a sixty-two-year-old woman who presented, in the psychotherapeutic process, a marked depression and severe unconscious feelings of guilt. The clinical reflections derived from the theoretical and practical questions brought by the patient's care and the improvement of her symptoms with psychotherapy motivated the elaboration of this article. The results indicate that the multiple and chronic intra-family traumas that occurred in childhood were important factors for the patient's depression, leading to believe that the trauma resulting from sexual abuse may be decisive for the future outbreak of this pathology.

Atendimento psicanalítico por telefone: Donald Winnicott, Walter Benjamin, a clínica no país das vozes / In treatment Psychoanalysis through phone calls: Benjamin, Winnicott, the clinic in the land of voices / Tratamiento psicoanalítico por teléfono: Benjamin, Winnicott, la clínica en el país de las voces / La psychanalyse par téléphone: Benjamin, Winnicott, la clinique au pays des voix

A partir da experiência de atendimento telefônico, o autor aborda outras, literárias e psicanalíticas, de uso do telefone e do rádio, aqui entendido como telefonema a um grande número de pessoas. Após aludir às maneiras inaugurais de considerar o telefone, sobretudo com Roland Barthes e Marcel Proust, estuda as experiências de Donald Winnicott e Walter Benjamin.

From the experience with telephone assistance, the author approaches others, literary and psychoanalytically, through telephone and radio, here understood as phone calls to a large number of people. After alluding to the inaugural ways of considering the telephone especially by Roland Barthes and Marcel Proust, he studies the experiences of Winnicott and Benjamin at length.

A partir de nuestra experiencia de asistencia telefónica, el autor se acerca a otras, literarias y psicoanalíticas, de uso telefónico y radiofónico, entendido como llamada telefónica a un gran número de personas. Tras aludir a las formas inaugurales de considerar el teléfono, especialmente con Roland Barthes y Marcel Proust, estudia detenidamente las experiencias de Winnicott y Benjamin.

À partir de notre expérience en matière de soins par téléphone, l'auteur aborde une expérience d'utilisation de la radio, laquelle est comprise ici comme un appel téléphonique à un grand nombre de personnes. Après avoir fait allusion aux premières façons d'envisager le téléphone, notamment avec Roland Barthes et Marcel Proust, il étudie longuement les expériences de Donald W. Winnicott et Walter Benjamin.