Wilm`s Tumor: Prognosis and Treatment / 대한비뇨기과학회지

Wilms` tumor originates from pleuripotential mesenchymal cells of the metanephrogenic blastema. Improvement on surgery and anesthesia, addition of radiation therapy and chemotherapy have produced remarkable improvements in survival over the past several decades. Twenty-eight patients with histologically confirmed diagnoses of Wilms` tumor were treated from l972 through l987 at the University Hospital, Keimyung University School of Medicine. l. Two year survival rate according to tumor stage was 80% in stage I, 7516 in stage II , 57.1% in stage III and 25% in stage IV and the overall 2 year survival rate was 57.1 1K . 2. Two year survival rate according to age was 75% in below l year, 50% between l to 2 years old, 54.5% between 2 to 6 years old and 60% above 6 years old. However, there seems to be no close relationship between age and prognosis. 3. Two year survival rate before 1978 was 45.5% and after 1978 was 45.5% and after 1978 it was 61.6% 4. There was 76.0 percent overall survival for those with negative nodes versus 33.3 per cent survival for those with positive nodes. 5. Two year survival rates of FH(Favorable Histology) and UH(Unfavorable Histology) were 68.2% and 16.7% respectively. There seems to be close relationship between FH and UH.

Correlation Between Histopathology and Prognosis in Wilms` Tumor: Result of a Retrospective Study of l0 Patients / 대한비뇨기과학회지

A histologic analysis of 10 cases of Wilms` tumor in the department of Urology, Chosun University Hospital during 11 years periods from January, l975 to December, l985 has been carried out. A classification based on the tumor differentiation and degree of tubular formation are described. A comparison of the histologic findings with the survival was undertaken and it was found that the histologic classification was significantly correlated with survivals. The results were as follows : I. Low grade tumors(grade I) with predominance of differentiated tubules were associated with a better cure rate than high grade tumors(grade IH) composed mainly of undifferentiated spindle elements : 2 year or more survival rate was lOOf6 for grade I but O% for grade III. 2. Cure rate was lower for the low degree of tubular formation than for the high degree of tubular formation : 2-year cure rates were O%, O%, 33.3%, lOO% for group O, +,++ and +++ respectively. 3. 6 patients with the focal or diffuse anaplasia and sarcomatous stroma had a bad prognosis. giving a survival rate of 0%.