Intestinal microecology on immune development during "The neonatal window of opportunity" and immunopathy / 国际儿科学杂志

Neonatal intestinal microecology is unstable and susceptible to various factors such as bacterial exposure, conditions that promote and inhibit bacterial growth, and host factors.These factors affect the initial development of the immune system during a critical period known as the "neonatal window of opportunity" . Epidemiological investigations have found a link between the development of the immune system during the "neonatal window of opportunity" and immune-mediated diseases.Recent studies have found that the principal mechanism may be promoting the development and maturation of the intestinal mucosal barrier, influencing the maturation of lymphocytes, and establishing immune tolerance.This review summarizes the effects of neonatal intestinal microecology on immune development during the "neonatal window of opportunity" .

Treatment of systemic juvenile idiopathic arthritis: is the conventional approach converted? / 中华实用儿科临床杂志

Systemic juvenile idiopathic arthritis (sJIA) is an inflammatory disorder characterized by fever,lymphadenopathy,arthritis,rash and serositis.In sJIA,systemic inflammation has been associated with dysregulation of the innate immune system,suggesting that it is an autoinflammatory disorder.Interleukin(IL)-1 and IL-6 play a major role in the pathogenesis of sJIA.Glucocorticoids and disease modifying anti-rheumatic drugs(DMARDS) are the conventional treatment of patients with sJIA.The major advances in the therapy of sJIA are the applications of IL-1 and IL-6 inhibitors and have shown to be highly effective.Recent data suggests that early cytokine blockage might alter the chronic arthritis course,which reflect a potential window of opportunity in the care of children with sJIA.The purpose of this article is to discuss the treatment approach of the patients with sJIA according to the recently published literature.