ABSTRACT
Wumei Pill is a classic insect repellent prescription, which is used for ascaris lumbricoides and diarrhea. It is considered to be a representative prescription for the treatment of simultaneous occurrence of cold and heat syndromes. Its prescription is mainly composed of sour drugs ( Mume Fructus and bitter wine) and pungent drugs ( Aconiti Lateralis Radix Praeparataaconite, Cinnamomi Ramulus, Sichuan pepper, Angelicae Sinensis Radix, Zingiberis Rhizoma, and Asari Radix et Rhizoma), supplemented by bitter drugs ( Coptidis Rhizoma and Phellodendri Chinensis Cortex) and sweet drugs ( Ginseng Radix et Rhizoma and honey). From the point of view of "Tang-Ye-Jing-Fa Map", the role of liver is to disperse, whose deficiency leads to limb syncope, and excess leads to the full of hypochondrium and abdominal pain. The pungent herbs can tonify the liver-deficiency, the sour herbs can dispel the liver-excess, and sweet herbs can relive them both. The role of spleen is to moderate, whose deficiency leads to fatigue and weakness, and excess leads to the vomiting and diarrhea. The sweet herbs can tonify the spleen-deficiency, the pungent herbs can dispel the spleen-excess, and bitter herbs can relive them both. Therefore, the function of Wumei Pills is located in the liver and spleen, giving consideration to the heart and lung. It is used for the deficiency and excess mixed syndrome of liver and spleen, which is mainly characterized by chest and flank abdominal pain, limb chills, diarrhea, muscle and pulse contracture and the symptoms of the parts along the liver meridian. It is commonly used in the treatment of ascaris, diarrhea, impotence, depression. At the same time, it can also be used for the treatment of diseases about heart and lung, and cough, anxiety and other diseases.
ABSTRACT
Objective In order to evaluate the clinical curative effect of double repletion and depletion acupuncture combined with Wumei pill for the sleep disorders after stroke.Methods A total of 150 patients of sleep disorders after stroke that accorded with the inclusion criteria was randomly divided into the treatment group and the control group.Thirteen patients were off loss in the study with 8.7％.And a total of 137 patients completed the protocol,including 70 in the treatment group and 67 in the control group.Both groups were treated with basic treatment.Besides,the treatment group added the treatment of double repletion and depletion acupuncture combined with Wumei pill;while the control group Estazolam tablet.There were 2 weeks for one course and 2 courses in total with 6 months follow-up.The PSQI,neurokinetic energy assessment and cognitive impairment were evaluated after treatment and 6 months follow-up.After treatment,plasma 5-HT and BDNF level were detected and clinical curative effect was observed.Results The PSQI score after treatment (6.3 ± 0.9 vs.9.3 ± 1.1,t=-3.424) 6 months followed up (4.2 ± 0.3 vs.7.5 ± 0.4,t=-3.675) in the treatment group was significantly lower than those in the control group (P＜0.05).The NIHSS score after treatment (8.2 ± 1.0 vs.11.4 ± 1.0,t=-4.557) and 6 months followed up (5.1 ± 0.5 vs.7.6 ± 0.9,t=-3.135) in treatment group was significantly lower than the control group (P＜0.05).The MMSE score after treatment (22.7 ± 2.9 vs.18.3 ± 2.8,t=-4.691) and 6 months followed up (25.0 ± 2.6 vs.21.5 ± 2.6,t=-4.902) in treatment group were significantly higher than the control group (P＜0.05).After treatment,the level of 5-HT (131.85 ± 11.72 ng/ml vs.101.21 ± 10.23 ng/ml,t=0.014) and BDNF (45.17 ± 6.03 ng/ml vs.38.46 ± 5.28 ng/ml,t=5.406) in treatment group were significantly higher than those in the control group (P＜0.05).After treatment,the treatment group effective rate was 92.9％ (65/70) and 81.6％ (54/67) in the control group.The difference was statistically significant (Z=-2.644,P=0.008).Conclusions The double repletion and depletion of acupuncture combined with Wumei pill can improve the sleep quality and cognitive behavior of patients with post-stroke sleep disorders.The possible mechanism is related with improvement of the expression level of 5-HT and BDNF.
ABSTRACT
Objective@#To explore clinical efficacy and safety of Wumeiwan combined with triple therapy for treatment of chronic atrophic gastritis (CAG).@*Methods@#According to the random indicator method, 113 patients with CAG were divided into control group (n=56) and treatment group (n=57). Patients of control group were treated with triple therapy, while treatment groupwere treated Wumeiwan combined with triple therapy. The two groups were treated for 3 months. Clinical effect was evaluated after treatment. The helicobacter pylori (Hp) conversion to negative of the two groups was compared and recorded. The Hp overcast conditions of the two groups were compared. The serum TNF-α, IL-6, IL-8 and peripheral blood CD3+, CD4+, CD8+, CD4+/CD8+ of the two groups before and after treatment were compared. The adverse reactions of the two groups during the treatment were compared.@*Results@#Total effective rate of treatment group was 94.7% (54/57), which was significantly higher than the control group 82.14% (46/56), and the difference was statistically significant (χ2=4.401, P=0.036). Hp overcast rate of treatment group was 88.2% (45/51), which was significantly higher than the control group 48.0%(24/50), and the difference was statistically significant (χ2=18.883, P=0.000). After treatment, the serum TNF-α (1.43 ± 0.17 mg/L vs. 1.97 ± 0.22 mg/L, t=14.615), IL-6 (30.79 ± 3.65 ng/L vs. 41.13 ± 4.10 ng/L, t=14.166), IL-8 (7.52 ± 1.32 ng/L vs. 9.60 ± 1.77 ng/L, t=7.090) in the treatment group were lower than those in the control group (P<0.05). After treatment, the peripheral blood CD3+ (75.12% ± 16.44% vs. 67.33% ± 14.37%, t=2.680), CD4+ (39.02% ± 11.41% vs. 33.49% ± 10.61%, t=2.667), CD4+/CD8+ (1.58 ± 0.35 vs. 1.19 ± 0.32, t=6.179) in the treatment group were higher than those in the control group (P<0.05), the peripheral blood CD8+ (24.75% ± 9.69% vs. 28.12% ± 11.29%, t=1.704) in the treatment group were higher than those in the control group (P<0.05). There was no significantly difference of the adverse reaction rates of the two groups during treatment (χ2=0.134, P=0.714).@*Conclusions@#The Wumeiwan combined with triple therapy for treatment of CAG has a good efficacy and low adverse reactions, has serious anti-inflammatory effects, can improve the body immunity, and it was worthy clinical application.