Comparison of X-ray mammography and ultrasound in the diagnosis of suspected breast lesions / 中国辐射卫生

Objective To evaluate and compare the diagnostic efficiency of X-ray mammography and breast ultrasound for suspected breast lesions. Methods A total of 80 female patients with suspected breast lesions diagnosed by X-ray mammography or breast ultrasound were selected as the study subjects. The histopathological testresults served as the gold standard, and the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of X-ray mammography and breast ultrasound for the diagnosis of breast lesions were estimated and compared. Results Among the 80 female patients with suspected breast lesions, 57 patients were histopathologically diagnosed with breast cancer and 23 patients with benign breast lesions. The sensitivity, specificity, NPV, PPV, and accuracy of X-ray mammography for the diagnosis of suspected breast lesions in women were 63.16%, 73.91%, 44.74%, 85.71%, and 66.25%, respectively, and those of breast ultrasound were 78.95%, 21.74%, 29.41%, 71.43%, and 62.50%, respectively. There were no significant differences between X-ray mammography and breast ultrasound for the diagnosis of suspected breast lesions in women in terms of sensitivity (χ2 = 3.45, P > 0.05), NPV (χ2 = 1.15, P > 0.05), PPV (χ2 = 2.92, P > 0.05), and accuracy (χ2 = 0.25, P > 0.05). However, specificity showed a significant difference between X-ray mammography and breast ultrasound (χ2 = 12.55, P < 0.01). Conclusion A comparable accuracy of X-ray mammography and breast ultrasound is found for the diagnosis of suspected breast lesions in women. However, X-ray mammography presents a significantly higher specificity than breast ultrasound for the diagnosis of suspected breast lesions in women.

Analysis of the relationship between the characteristics of X-ray and MRI and the level of ER/PR/HER2 expression in breast cancer patients / 国际检验医学杂志

Objective To explore the relationship between the characteristics of X-ray and magnetic resonance imaging(MRI) and the expression level of estrogen receptor(ER),progesterone receptor(PR)and human epithelial factor receptor 2(HER2)in breast cancer patients.Methods 108 cases of breast cancer patients in the first 74 Hospital of the PLA from January 2013 to Janu-ary 2017 were selected as the research object.Clinical,pathological and imaging data of patients were collected.All patients were ex-amined by X-ray and MRI after admission.The expressions of ER,PR and HER2 in cancer cells were detected by immunohisto-chemical staining.Results The expression of ER,PR and HER2 was positive in 73 cases(67.59%),63 cases(58.33%)and 43 ca-ses(39.81%),respectively.The positive rate of HER2 in patients with calcification was higher than that in patients without calcifi-cation(P<0.05).The positive rate of PR in patients with calcification along the duct was lower than that in patients of whom the calcification was not along the duct,and the positive rate of PR in patients with glandular or mixed density was higher than that in patients with structural disorder(P< 0.05).The positive rate of ER was higher in patients with calcification,mass,spiculation signs,glandular or mixed density(P<0.05).There were significant differences in the positive rate of HER2 between patients with different shapes and different enhancement modes(P<0.05),and there was a significant difference in the positive rate of PR be-tween patients with different enhancement modes(P<0.05).Calcification displayed by X-ray mammography was positively corre-lated with HER2,calcification along the duct was negatively correlated with the expression of PR,calcification with mass was posi-tively correlated with ER and negatively correlated with PR,spiculation sign was positively correlated with ER,and structural disor-der was negatively correlated with ER and PR.Mass type and inhomogeneous enhancement of MRI signs were negatively correlated with HER2,irregular shape was positively correlated with HER2,and inhomogeneous enhancement was positively correlated with PR (r = 0 .363 ,- 0 .375 ,0 .368 ,- 0 .326 ,0 .426 ,- 0 .489 ,- 0 .373 ,- 0 .468 ,- 0 .403 ,0 .391 ,0 .425 ;P < 0 .05) .Conclusion There is a correlation of signs of X‐ray mammography and MRI signs with the expression of ER ,PR and HER2 .Imaging changes can predict the expression of some biological factors of breast cancer ,which is related to hormones ,chemotherapy sensitivity and the prognosis of patients.

Evaluation performance of calibration apparatus for dosimeters used in X-ray mammography / 中华放射医学与防护杂志

Objective To fulfill the requirements for uncertainty of the calibration apparatus for dosimeters used in X-ray mammography through setting standard radiation quality at the SSDL and developing calibration procedures.Methods According to IEC 61267-2005 and IAEA TRS No 457 to recommend RQR-M and RQA-M series standard radiation quality,the calibration apparatus was evaluated for long term stability of the radiation field over 8 years from 2006 to 2014,including 10 response quantities,such as field homogeneity,change rate of mean air kerma and scatter radiation contributions and so on.In addition,the reference dose instrument was traced back to the PSDL of PTB in Germany by post during 2008 and 2012.Results The field homogeneity (φ 40 mm) relative error was ± 1.4％.The long term stability of the calibration apparatus was less than ± 2％ (limits of variation).The scatter radiation contributions at their points of test were below 0.12％.The calibration factors traced to PTB were 0.999-1.000.As a result of the calibration apparatus,the expanded uncertainty was ± 3％ (k =2,95％ confidence interval).Conclusions The calibration apparatus may meet the requirements of IEC 61267-2005 and IAEA TRS No 457 and has obtained the license of metrology from national regulatory authority.The laboratory now performs very well to calibrate dosimeters used in X-ray mammography.

The Study of Different Presentations of Breast Lumps in Radiographic Imaging.

Introduction: Breast USG is an established and accurate tool for the primary evaluation of breast lumps and pathology. It also compliments X- ray mammography in further evaluation and characterization of breast masses and thus avoids surgeries in benign breast diseases and pathology. Method: For USG examination of the breast lumps, a linear-array transducer of 5-7 MHz frequency is required with a good resolution machine. Results: We present a pictorial essay on the role of USG in evaluation and characterization of various breast lumps and pathology. Conclusion: Breast sonography considerably improves the visualization and evaluation of lumps in mammographically radiodense breasts and helpful in the characterization of it, either as solid or cystic lesion. It also improves the specifi city of X-ray mammography when used as an adjunct to it. It is also helpful in guiding FNAC/biopsy from the breast masses.

Ductoscopy combined X-ray mammography for breast cancer screening / 国际外科学杂志

Objective Understand shunde Uistrict Foshan City,Guangdong Province in the incidence of breast cancer in women.Methods The joint selectivity ductoscopy examination of the clinical breast examination screening,breast X-ray radiography examination from March 2011 to January 2013,Shunde District,FoShan City,Guangdong Provice,3 600 bladder than 40 years old woman with breast cancer screening.Results Three thousand six hundred women were found in 10 cases of breast cancer,the detection rate of 278/100 000 (10/3 600).Breast clinical examination found 1 313 cases of breast abnormalities,142 cases of breast lumps,nipple discharge line fiberoptic ductoscopy to cheek the 100 cases,X-ray radiography examination of four and more than 72 cases,accounted for a total of 45.19％ of the screening population (1 627/3 600).Conclusions Joint ductoscopy X-ray radiography examination of breast cancer screening in the normal population can help to detect early breast cancer,and to provide the basis for early clinical treatment.

~(99m)Tc-octreotide scintigraphy and planar X-ray mammography diagnosis of breast cancer / 中国医学影像技术

Objective To compare the value of (~99m) Tc-octreotide scintigraphy and planar X-ray mammography in the diagnosis of breast cancer. Methods A total of 32 patients with suspected breast cancer were enrolled into this study. All patients underwent (~99m) Tc-octreotide scintigraphy and planar X-ray mammography. The diagnostic efficiency of (~99m) Tc-octreotide scintigraphy and planar X-ray mammography were compared based on the post-surgery pathology. Results The sensitivity of (~99m) Tc-octreotide scintigraphy and planar X-ray mammography in the diagnosis of breast cancer was 91.67% and 66.67%, the specificity was 100% and 37.50%, the accuracy was 93.75% and 59.38%, respectively. Combining (~99m) Tc-octreotide scintigraphy with planar X-ray mammography, the sensitivity, specificity, accuracy, positive predicting values and negative predicting values for breast cancer was 95.83%, 100%, 96.88%, 82.14% and 47.06%, respectively. Conclusion The diagnostic efficiency of (~99m) Tc-octreotide scintigraphy for breast cancer is superior to planar X-ray mammography. (~99m) Tc-octreotide scintigraphy combined with planar X-ray mammography, the diagnostic efficiency for breast cancer will be further improved.

To assess the value of X-ray mammography and cytopathology test for breast cancer diagnosis of early stage Tis and T1

Background: Breast cancer is not only the most popular in women but is also one of the main causes of death among them in many countries. In Hanoi 1999, the prevalence of breast cancer was 21.8 per 100,000 of the population and was the main cause of death in women. In Ho Chi Minh city that prevalence was 17.1 per 100,000 of the population and was the second highest cause of death in women. Objectives: To assess the value of X-ray mammography and cytopathology test for breast cancer diagnosis of early stage Tis and T1. Subjects and method: A retrospective study was conducted among 103 breast cancer patients with malignant tumor size \uf0a32cm, who were admitted to K Hospital and Thanh Nhan Hospital from 01/2003 to 02/2008. Results:Breast malignant tumor was usually found most frequently at the upper outer quadrant. Around 86.4% of patients who were suspected with malignant lesion by X-ray mammography. Using biopsy test for breast cancer diagnosis, the results shows that 78.6% of patients were positive, 15.6% of cases were suspected and 5.8% had wrong diagnosis. Pathologic classifications were as followed: invasive lobular carcinoma: 78.6%, intraductal carcinoma in situ (Tis): 4.9%. Conclusion: X-ray mammography and cytopathology test are useful tools for the diagnosis of breast cancer.