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1.
Korean Journal of Dermatology ; : 935-937, 2001.
Article in Korean | WPRIM | ID: wpr-203213

ABSTRACT

We report a case of type V hyperlipoproteinemia with xanthoma eruptivum associated with diabetes mellitus. An 18-year-old female patient presented with multiple, erythematous papules on the trunk, buttocks, and both extremities and multiple orange-yellow colored, conglomerated nodules on the elbows and knees. Laboratory examination showed increased serum blood glucose, cholesterol and triglyceride. Lipoprotein electrophoresis showed increased pre-beta and chylomicron bands. Analysis of lipoprotein revealed increase of very low density lipoprotein (VLDL) and triglyceride levels in the plasma. A skin biopsy from the papule on the trunk revealed a xanthoma. We diagnosed the patient as type V hyperlipoproteinemia. After 10 months of treatment with insulin and gemfibrozil, the serum levels of cholesterol and triglyceride were reduced to normal level. The skin lesions showed marked improvement without scar.


Subject(s)
Adolescent , Female , Humans , Biopsy , Blood Glucose , Buttocks , Cholesterol , Cicatrix , Diabetes Mellitus , Elbow , Electrophoresis , Extremities , Gemfibrozil , Hyperlipoproteinemia Type V , Insulin , Knee , Lipoproteins , Plasma , Skin , Triglycerides , Xanthomatosis
2.
Korean Journal of Dermatology ; : 693-695, 2001.
Article in Korean | WPRIM | ID: wpr-177498

ABSTRACT

We report a case of type V hyperlipoproteinemia with xanthoma eruptivum in a 30-year-old male. He had diffuse erythematous yellowish papules on both extremities and the buttock. The laboratory findings showed the increased cholesterol and the triglyceride. Serum electrophoresis showed an increase in pre-beta and chylomicron, suggesting type V hyperlipoproteinemia. The biopsy specimen of an erythematous yellowish colored papule on the right knee showed many aggregates of foam cells without Touton giant cells.


Subject(s)
Adult , Humans , Male , Biopsy , Buttocks , Cholesterol , Electrophoresis , Extremities , Foam Cells , Giant Cells , Hyperlipoproteinemia Type V , Knee , Triglycerides , Xanthomatosis
3.
Korean Journal of Dermatology ; : 561-563, 2000.
Article in Korean | WPRIM | ID: wpr-86881

ABSTRACT

We report a case of type V hyperlipoproteinemia and xanthoma eruptivum associated with diabetes mellitus in a 12-year-old female. She had diffuse erythematous yellowish papules on the extremities and trunk with itching. The laboratory findings showed increased serum blood glucose, cholesterol and triglyceride, increasing pre- and chylomicron bands on electrophoresis of lipoprotein. The biopsy specimen of an erythematous yellowish colored papule on the trunk showed characteristic findings of xanthoma.


Subject(s)
Child , Female , Humans , Biopsy , Blood Glucose , Cholesterol , Diabetes Mellitus , Electrophoresis , Extremities , Hyperlipoproteinemia Type V , Lipoproteins , Pruritus , Triglycerides , Xanthomatosis
4.
Korean Journal of Dermatology ; : 697-702, 1996.
Article in Korean | WPRIM | ID: wpr-171077

ABSTRACT

We report a case of type IV hyperlipoproteinemia associated with xanthoma tuberosum and xanthoma eruptivum, which improved by treatment with gernfibrozil and procetofene. A 46-year-old male patient visited our clinic for evaluation of multiple orange-yellow colored nodules on the elbows and multiple papules on the knees, buttocks and back. Laboratory examination showed an abnormal elevation of serun cholesterol and triglyceride. Lipoprotein electrophoresis showed an increase of pre-b band and plasma standing test showed turbid plasma. Analysis of lipoprotein revealed increase of VLDL level in his plasma. The biopsy specimens from the nodule on the elbow and the papule on the back revealed characteristic findings of xanthoma. We diagnosed the patient as type IV hyperlipoproteinemia. After 5 months of treatment with diet restriction, gemfibrozil, and procetofene, the serum levels of cholesterol and triglyceride were reduced to normal level. The skin lesions of the both back and buttock showed marked improvement and the skin lesions on the elbows and knee were much improved.


Subject(s)
Humans , Male , Middle Aged , Biopsy , Buttocks , Cholesterol , Diet , Elbow , Electrophoresis , Fenofibrate , Gemfibrozil , Hyperlipoproteinemia Type IV , Knee , Lipoproteins , Plasma , Skin , Triglycerides , Xanthomatosis
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