Effect of Xiaoyu Anshen Capsule on Space Learning-memory Ability of Chronic Stress-induced Depressed Model Rats / 中国药房

OBJECTIVE:To explore the effect of Xiaoyu anshen capsule on the space learning-memory ability of chronic stress-induced depressed model rats.METHODS:The enrolled rats were divided into 6 groups:blank control group,model group,Fluoxetine group,Xiaoyu anshen capsule groups(high,medium and low dose).Chronic depression rat model was induced by chronic stress and isolated breeding.Water-maze video tracking analysis system was used to detect the capacity of rats' space learning-memory,and the indexes such as the body weight of rats before and after modeling and the consumption of sucrose,etc.were measured.RESUTLS:Compared with the blank control group,the model control group showed significantly decreased space learning-memory capacity,significantly lower in body weight increase and significantly less sucrose solution consumption.Compared with the model control group,the high,medium and low dose Xiaoyu anshen capsule-treated group showed significantly shortened escape latency,the high and medium dose groups showed increased number of times of crossing the hidden platform and body weight increase,and in high dose Xiaoyu anshen capsale group sucrose consumption increased.CONCLUSION:Xiaoyu anshen capsule is a nootropic Chinese herbal medicine for its inhibitory effect on the abnormality in body weight and sucrose solution consumption of chronic stress-induced depressed model rats and their action in enhancing the space learning-memory ability.

Optimization of the Inclusion Process of Essential Oil in Xiaoyu Anshen Capsules / 中国药房

OBJECTIVE:To optimize the inclusion process of the volatile oil of Pogostemon cablin and Acorus tatarinowii in Xiaoyu anshen capsule.METHODS:The inclusion process was carried out by saturated water solution method.And the inclusion process was optimized by orthogonal experiment with the inclusion ratio and yield of the volatile oil as indexes taking the ratio of volatile oil to ?-CD,the temperature and the time of inclusion as factors.The physical phase of the inclusion complex was detected by differential scanning calorimetry(DSC).RESULTS:The optimum inclusion process was established as follows:the ratio of oil to ?-CD=1∶8;the ratio of water to ?-CD=10∶1;the inclusion time was 1h and the inclusion temperature was 50 ℃.The inclusion rate was as high as 90%.The DSC revealed that a new physical phase has been formed for the inclusion complex.CONCLUSION:The intermolecular inclusion complex with good stability and high yield of volatile oil could be obtained from the optimized inclusion process.