ABSTRACT
Objective To establish a method for quality control of xinshuaining mixture. Methods The herbal contents including red ginseng,milk veteh,root of red rooted salvia were identified by thin layer chromatography ( TLC) and the content of ginsenoside Rb1 in xinshuaining mixture was determined by high performance liquid chromatography ( HPLC ) . Results The herbs can be overtly identified by TLC. Ginsenoside Rb1 had a linear relationship in the range of 1. 095-5. 475μg, and the average recovery was 97. 3%(RSD 1. 98%). Conclusion The method is simple and rapid,and can be used for the quality control of xinshuaining mixture.
ABSTRACT
Objective To investigate the myocardial remodeling and cardiac function effects of metoprolol combined Xinshuaining mixture for treating chronic heart failure.Methods One hundred and seventy patients with chronic heart failure was equally divided into treatment group and control group of 85 cases each,accorded to the random principle of parallelism,both groups were given conventional treatment based on metoprolol,the treatment group was added Xinshuaining mixture.Results After treatment,the effective rate in the treatment group was 95.3 ％(81/85),so that was 81.2％(69/85) in the control group,there was significant difference (P ＜ 0.05).After treatment,the level of left ventricular end-systolic volume (LVESV),left ventricular end-diastolic volume (LVEDV),heart rate (HR) in treatment group were significantly lower than those in control group [(41.36 ±7.11) ml/m2 vs.(44.32 ±6.26) ml/m2,(46.28 ± 7.56) ml/m2 vs.(55.69 ± 8.12) ml/m2,(72.25 ± 3.62) bpm vs.(78.36 ± 3.44) bpm],while the level of left ventricular ejection fraction (LVEF) and 6-minute walk test distance were significantly higher [(56.48 ±8.00)％ vs.(35.16 ± 8.21)％,(566.68 ±51.86) m vs.(476.88 ±50.99) m],there were significant differeces (P ＜ 0.05).After followed up for 3 months,the incidence of cardiac adverse reactions in treatment group was significantly lower than that in control group [3.5％ (3/85)vs.11.8％ (10/85)] (P ＜ 0.05).Conclusions Metoprolol combined Xinshuaining mixture for treating chronic heart failure can improve cardiac remodeling and heart function,thereby improve the prognosis of efficacy.While its better security should be widely applied.