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Objective:To observe the clinical effect of Xuefuzhuyu decoction in the treatment of cancerous fever .Methods:Ac-cording to the admission order , 62 cases of patients with cancerous fever were divided into observation group (32 cases) and control group(30 cases).The observation group was treated with Xuefuzhuyu decoction , while the control group was treated with naproxen . The treatment course was 7 days.The changes of body temperature and KPS score were compared between the groups before and after the treatment,and the clinical efficacy of the two groups were evaluated .Results:After the 5-7-day treatment, the average body tem-perature in the observation group was significantly lower than that in the control group (P<0.05).After the treatment, the total effec-tive rate of the observation group was 75％, which was much higher than that (50％) of the control group (P<0.05).The rate of KPS score keeping stable or ≥10 in the observation group was much higher than that in the control group (P<0.05).Conclusion:Xuefuzhuyu decoction is effective and safe in the treatment of cancerous fever with better efficacy than naproxen , which can improve pa-tients' quality of life with important clinical significance .
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Aim To investigate the role of Xuefuzhuyu decoction ( XFZYD ) combined with EPC in repairing damaged vascular endothelium using traditional Chi-nese medicine way of blood circulation combined with cell therapy. Methods The repaired situation of inju-ried endothelium was observed and the effect of XFZYD on EPC was analysed after the endothelial in-juried rats were gavaged XFZYD and vena caudalis in-jected EPC. Results Compared with EPC group and XFZYD group, the XFZYD joint EPC group ’ s endo-thelial thickness was reduced significantly(P<0. 05). And there appeared more significant role in lowering triglycerides, total cholesterol and increasing HDL lev-els( P<0. 05 ) , the calcium was decreased more sig-nificantly( P <0. 05 ); vascular eNOS protein expres-sion increased significantly(P<0. 05); vascular SDF-1 expression was significantly increased. Conclusion XFZYD can promote EPC repairing damaged endotheli-um, and the mechanism may be relevant to improving the environment and promoting the EPC homing.
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Objective To explore the influence of new Xuefuzhuyu decotion on IgG,C3 and C4 of peripheral blood in atherosclerosis rats.Methods Healthy adult Wister rats were selected and randomly divided into blank group,AS model group,new Xuefuzhuyu decoctioin low dosage group,the new Xuefuzhuyu decoctioin high dosage group,and positive control group,with 13 cases in each group.Vitamin D3 joint high fat feeding method was adopted to establish atherosclerosis rat model.Medicine lavage began on the first day of experiment.Low dosage new Xuefuzhuyu decoctioin,high dosage new Xuefuzhuyu decoctioin,and atovastatin were administrated to the new Xuefuzhuyu decoctioin low dosage group,the new Xuefuzhuyu decoctioin high dosage group,and positive control group respectively,and distilled water 15 ml/kg · d-1 was administrated to both the blank group and the AS model group.The weight of body was detected each week in each group for regulating the administrated dosage.After medicine lavage was performed for successive 8 weeks,blood was obtained from abdominal aorta for detecting IgG,C3,C4 by immune scattering method.Results The value of IgG,C3 and C4 were (8.110±0.720)g/L,(1.591±0.143)g/L,(0.390±0.33)g/L in the AS model group,(8.000±0.840)g/L,(1.564± 0.132) g/L,(0.396±0.36)g/L new Xuefuzhuyu decoctioin low dosage group,(7.250±0.740)g/L,(1.390±0.150)g/L,(0.326±0.153)g/L new Xuefuzhuyu decoctioin high dosage group and (7.240±0.400) g/L,(1.414 ± 0.104) g/L,(0.330±0.164) g/L in the positive control group,all of which werehigher than the blank group (5.810±0.820)g/L,(0.943±0.124)g/L,(0.330±0.164)g/L with statistically significant difference (P＜0.05).Each value of IgG,C3 and C4 in the new Xuefuzhuyu decoctioin high dosage group and the positive control group were lower than the AS model group and the new Xuefuzhuyu decoctioin low dosage group,with a statistically significant difference(P＜0.05).There was no significant difference between new Xuefuzhuyu decoctioin high dosage group and the positive control group (P＞0.05).Conclusion New Xuefuzhuyu decoction can ameliorate IgG,C3 and C4 of peripheral blood in atherosclerosis rats.Its function was similar to atorvastatin.
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Objective To observe the therapeutic effect of treating myocardial ischemia in CHD with Junanyin. Methods All patients with myocardial ischemia in CHD were randomly recruited into a control group and a treatment group,with 43 patients in each group. The treatment group was treated with Junanyin, one dose daily, on the basis of conventional treatment; while the control group was treated with Huoxuezhuyu decoction on on the basis of conventional treatment, one dose daily. The results were compared after 8 weeks. Results The outstanding cure rate and total effective rate in the treatment group were both statically better than the control group, with (χ2=9.53, P＜0.05) and (χ2=19.5, P＜0.05)respecitvely. Conclusion Junanyin was effective to treat myocardial ischemia in CHD.