ABSTRACT
Objective To investigate the variation of the preparation time of Yuhong Ointment under conditions of accelerated test and long-term test;To provide the necessary data for the production and new medicine application, and establish the period of validity. Methods Referring to the current guiding principles of TCM stability test, the conditions of affecting factors in trial test and long-term test were decided:β,β'-dimethylacrylshikonin content was set as quantitative indicators, combined with the key items of stability test to evaluate the stability;its validity predictive value was deduced by using statistical methods. Results In the conditions of high temperature (30 ± 2 ℃, RH 45% ± 5%), high humidity (25 ± 2 ℃, RH 75% ± 5%), and hard light (4500 ± 500 Lx, 25 ± 2 ℃, RH 45%± 5%) for 10 days, the traits, appearance and content were in line with requirements. The validity of Yuhong Ointment under 25 ℃ conditions was 41.216 months. Conclusion Under current production conditions, the stability of Yuhong Ointment is good.
ABSTRACT
Objective To observe the effect of Yuhong ointment on secretion of Substance P of promoting wound healing and explore its mechanism. Methods The whole layer skin defection rat was used and randomly divided into 3 groups:Yuhong ointment group,Jingwanhong group,model group,with normal rats as control. The condition of skin wound surface and healing time were observed and recorded at 1,3,5,7,10,14,21,30 day after wound. The expression of Substance P were measured and compared by immunohistochemistry staining. Results Average wound healing rate had no significant difference between Yuhong ointment group and Jingwanhong group,which were higher than model group (P
ABSTRACT
[Objective] To observe the therapeutic effect of Shengji Yuhong Ointment (SYO) in promoting healing of postoperative wound of tuberculous perianal abscess and anal fistula. [ Methods ] Forty cases of tuberculous perianal abscess and anal fistula after operation were divided into group A ( n = 20) and group B ( n = 20) according to the odd-or even-numbered days of admissions. Group A was treated with external application of SYO and group B with external application of vaseline ointment. After treatment, the healing of postoperative wound was observed in the two groups. [Results] In group A, the time for the ceasing of exudates from wound surface, for the formation of granulation and epithelial tissue, and for the healing of wound was shorter than that in group B ( P