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Objective:To observe any effect of Yun shou tai chi training with visual feedback on the balance of persons who have survived a stroke.Methods:Fifty-six stroke survivors were randomly divided into an observation group and a control group, each of 28. Both groups were given routine balance function training, while the observation group was additionally given Yun shou tai chi training with visual feedback. Before and after the four weeks of training, the subjects′ balance and posture were evaluated using a Nomex visual feedback balance system. Lower limb strength was evaluated with a microFET2 portable muscle strength tester. The Berg Balance Scale (BBS), Timed Up and Go Test (TUGT), 10-metre walk times (10MWTs) and the modified Barthel Index (MBI) were also applied.Results:After the training the average BBS, TUGT, 10MWT and MBI results of the observation group had improved significantly. Among the control group only TUGT times and MBI scores had improved significantly, but even then the average MBI score of the observation group was significantly higher. The training improved the strength of the trainees′ quadriceps femoris (QUA), tibialis anterior (TA) and gastrocnemius (GAS) on the hemiplegic side. Their hamstrings and GAS on the non-hemiplegic side were also significantly stronger, on average. The improvement in the QUA of the hemiplegic side in the observation group was significantly better than the control group′s average improvement. The path length (PL) and the covered area (CA) in the observation group had decreased significantly after the training, while among the controls only the CA had decreased significantly. The average PL in the observation group was therefore significantly shorter than in the control group.Conclusion:Yun shou tai chi training with visual feedback can promote the recovery of balance function after a stroke. Such training is worthy of clinical promotion and application.
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Objective:To investigate the clinical efficacy of Yunkang oral liquid combined with dexamethasone and low-molecular-weight heparin in the treatment of recurrent spontaneous abortion (RSA) complicated with pre thrombotic state (PTS), and its effects on thromboelastogram and serum progesterone, β-human chorionic gonadotropin (β- hCG), and helper T cell (Th) 1/Th2 cytokine levels in patients with recurrent spontaneous abortion (RSA).Methods:A prospective selection of 94 RSA patients with PTS admitted to the Baoding Second Central Hospital from January 2015 to December 2020 was conducted. They were randomly divided into two groups using a random number table method, with 47 patients in each group. The control group was treated with dexamethasone combined with low molecular weight heparin, while the observation group was treated with Yunkang oral liquid in addition to the control group. Continuously treat until 12 weeks of pregnancy to evaluate the efficacy of both groups and observe the adverse reactions in both groups. Two sets of thromboelastogram parameters were compared before and after treatment, including clot formation time (K value), clot reaction time (R value), and clot formation rate (α angle), maximum clot strength (MA value), and coagulation comprehensive index (CI), as well as serum progesterone β- hCG, Th1/Th2 cytokine levels. The pregnancy outcomes of the two groups were followed up.Results:The total effective rate of the observation group [95.7%(45/47)] was significantly higher than that of the control group [83.0%(39/47), P<0.05]. After treatment, the K and R values of both groups were significantly prolonged compared to before treatment (all P<0.05), the angle α, MA value, and CI value were significantly reduced compared to those before treatment (all P<0.05); After treatment, the K and R values in the observation group were significantly longer than those in the control group (al P<0.05), The angleα, MA value, and CI value were significantly lower than those of the control group (all P<0.05). After treatment, the levels of β- hCG serum progesterone of the two groups were significantly higher than those before treatment (all P<0.05), and The β-hCG levels of the serum progesterone were all higher than those in the control group (all P<0.05). After treatment, The levels serum Th1 cytokines [interferon-γ (INF- γ), tumor necrosis factor- α (TNF- α)] of both groups were significantly decreased compared to those before treatment (all P<0.05), and the levels of serum Th2 cytokines [interleukin-4, IL-10] were significantly increased compared to those before treatment (all P<0.05); After treatment, the observation group's serum IFN- γ, TNF- α were significantly lower than those of the control group (all P<0.05), and The levels of serum IL-4 and IL-10 were significantly higher than those of the control group all P<0.05). The live birth rate of the observation group was 87.2%(41/47), which was higher than that of the control group [70.2%(33/47)] ( P<0.05). There was no statistically significant difference in the adverse reaction rate between the observation group [6.4%(3/47)] and the control group [4.3%(2/47)] ( P>0.05). Conclusions:The treatment of RSA combined with PTS with Yunkang oral liquid, dexmedroxyprogesterone, and low molecular weight heparin can significantly alleviate blood hypercoagulability, increase reproductive endocrine hormone levels, regulate Th1/Th2 cytokine balance, improve live birth rate and clinical efficacy, and is safe and reliable.
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Objective: To observe the clinical efficacy of pediatric Tuina (Chinese therapeutic massage) plus oral administration of Chinese medication for pediatric anorexia due to spleen failing in transportation. Methods: A total of 94 children with anorexia due to spleen failing in transportation were randomized into an observation group and a control group by the random number table method at a ratio of 1:1, with 47 cases in each group. The control group was treated with modified Bu Huan Jin Zheng Qi San, and the observation group was treated with additional Tuina manipulation of Yun Shui Ru Tu based on the treatment in the control group. After 4 weeks of treatment, the clinical efficacy of the two groups was observed, and the traditional Chinese medicine (TCM) symptom score, serum leptin, neuropeptide Y, and serum zinc and calcium levels were compared. Results: After 4 weeks of treatment, the total effective rate of the observation group was 87.2％, and that of the control group was 74.5％. The difference between the two groups was statistically significant (P<0.05). After treatment, the TCM symptom scores in both groups decreased significantly (P<0.05), and the scores in the observation group were lower than those in the control group (P<0.05). After treatment, the serum leptin level in both groups decreased, and the level in the observation group was lower than that in the control group (P<0.05). The serum neuropeptide Y, zinc, and calcium levels in both groups increased after treatment, and the levels in the observation group were higher than those in the control group (P<0.05). Conclusion: Tuina manipulation of Yun Shui Ru Tu plus oral administration of Chinese medication is significantly effective in treating pediatric anorexia due to spleen failing in transportation, which can improve the appetite of children and improve the symptoms of anorexia, and the curative effect is better than that of oral administration of Chinese medication alone.
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Objective@#To observe the effects of Chinese herbalprescription Tizhi-Pingtiao Powder (TP) based on Five-Yun Six-Qi theory to treat hyperlipidemia (HLP).@*Methods@#This study included 641 HLP patients from Constitution medicine clinic in Dongzhimen hospital from January 2015 to November 2017. The embryonic period’s (ten months) Five-Yun Six-Qi endowments of the enrolled patients were analyzed and TP were prescribedaccordingly, in the absent of lipid-lowering drugs. The curative effect was observed after three months’ TP treatment and reviewed ofeach 3 months, and long-term effects will be observed for 1 year,either take the priscription or not. Curative effect is based on blood lipids maintain normal as well as constitution improved while stopped lipid-lowering drugs.@*Results@#Among the 641 patients who met the inclusion criteria, 379 patients take on complete, and 300 patients (79.2%) were clinically cured (with blood lipid decreased to normal, overall constitution and complication condition improved), 375 patients (99.0%) were completely cured. Among 262 patients without dietary restriction, 143 patients (54.6%) were clinically cured, 240 patients (91.6%) were completely cured. Long-term effects showed that 210 patients stopped the TP after 3 months' treatment, the recurrence rate at the end of the 3rd month, 6th month and 12th month in the patients who were on complete dietary restriction were 4.1%, 48.8% and 76.9%, while the recurrence rate in the patients who had not implemented dietary restriction were 37.1%, 70.8%, 89.9%. A total of 115 patients continued the TP for the other 12 months, the recurrence rate at the end of 3rd month, 6th month and 12th month in the patients who were on complete dietary restriction were 2.5%, 4.8% and 6.0%, while the recurrence rate in the patients who had not implemented dietary restriction were 6.5%, 16.1%, 29.0%. The difference between the four groups was significant. All recrudescent patients could gain recovery in a month after re-taking the herbs.@*Conclusions@#Chinese herbal priscription TP combined with dietary modification showed long term effect for HLP and improve the constitution comprehensively.
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OBJECTIVE@#Through the establishment of abortion model caused by embryo implantation difficulties, exploring the role of Yun Kang oral liquid in protecting embryos.@*METHODS@#The pregnant rats were divided into 6 groups:normal control group (NC), model group (MG), dydrogesterone group (DT), and three dose groups of low, medium and high levels of Yun Kang oral liquid (YK-L, YK-M, YK-H), 11 in each group.From the first day of pregnancy, daily intragastric administration, the dose of DT group was 3.02 mg/kg, and the doses of Yun Kang oral liquid were 4, 6, and 9 ml/kg, respectively.The rats in NC and MG were treated with an equal volume of purified water for 10 days.On the third day of pregnancy, except for the NC group, the other groups were injected with mifepristone subcutaneously at the back of the neck at a dose of 5 mg/kg to cause an embryo implantation barrier model.On the 10th day of pregnancy, blood was collected from the abdominal aorta in each group.Serum follicle stimulating hormone (FSH), interferon-γ (IFN-γ) and interleukin (IL-4) were measured by enzyme-linked immunosorbent assay.The number of embryo implantation was observed in the uterus, and the pathological changes of the uterus were observed by HE staining.@*RESULTS@#Compared with the NC group, the number of embryo implantation and the serum levels of FSH and IL-4 in the MG group were decreased significantly (< 0.05, 0.01), and pathological changes such as uterine glandular epithelial hyperplasia and inflammatory cell infiltration in the glandular cavity were observed.Compared with MG group, the number of embryo implantation and serum FSH and IL-4 levels of rats in YK-M and YK-H groups were increased significantly (<0.05, 0.01).The pathological changes such as uterine glandular epithelial hyperplasia and inflammatory cell infiltration in the gland were also improved.There was no significant difference in serum IFN-γ levels between the groups.@*CONCLUSIONS@#Yun Kang oral liquid may improve the endometrial pathological changes and increase the number of embryo implantation by increasing the levels of serum sex hormone FSH and immune cytokine IL-4 in embryo implantation impediment rats.
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Animals , Female , Pregnancy , Rats , Cytokines , Embryo Implantation , Interferon-gamma , UterusABSTRACT
Objective To investigate the curative effect of YU Yun pulse-feeling-based acupuncture therapy for the treatment of middle-late liver cancer. Methods A total of 60 middle-late liver cancer patients were divided into control group and treatment group by stratified randomization method,30 cases in each group. The control group was given integrated Chinese and western medicine therapy according to the clinical pathway, including anti-cancer treatment such as vascular interrention,molecular targeted therapy,chemotherapy,radio therapy, and focal ablation therapy,as well as chinese medicine treatment based on disease differentiation and syndrome differentiation. And the treatment group was given YU Yun pulse-feeling-based acupuncture therapy on the basis of treatment for the control group. The two groups received 12-week treatment, and then their curative effects were compared. Results The treatment group had better effect on increasing the survival rate, prolonging survival time, improving the scores of clinical symptoms, stabilizing tumor size, and increasing the scores of Karnofsky Performance Status (KPS)than the control group,the difference being significant (P < 0.05 or P <0.01). Conclusion YU Yun pulse-feeling-based acupuncture therapy exerts certain curative effect for the treatment of middle-late liver cancer.
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This article discussed Professor LI Li-yun's treatment experience in infertility caused by uterine factors from etiology, pathogenesis, treatment and prescription. Professor LI believes that a wide variety of pathogenic factors can lead to infertility caused by uterine factors, including cold, heat, deficiency and excess. According to this, the pathogenic factors should be distinguished and treatment should be conducted based on syndrome differentiation. Medical cases were studied to further explore Professor LI's clinical thoughts.
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This article introduced the experience of Professor YU Yun in treating the primary carcinoma of liver by using acupuncture after pulse diagnosis. Professor YU thinks that the overall pathogenesis of liver cancer is deficiency of zang-fu organs, so the cancer cells can invade and occupy in the liver. Therefore, Professor YU uses the way of supporting the healthy qi and driving out the cancer as the treatment principle from multiple organs and meridians. On the basis of the theories of Nei Jing, Professor YU creates the acupuncture after pulse diagnosis. He feels the pulse on the basis of four pulses: Cunkou, Renying, Chongyang, and Taixi. According to the feelings of the pulses, he compares the size and speed, strong or weak, smooth or nonfluency of the four pulses. In treatment, he uses reducing method when the pulse is strong and fast, and tonic method when the pulse is weak and slow. He chooses the main acupuncture points on head, face, belly, flank and lower limbs. According to the experience, Professor YU uses gold needle in tonic method and uses silver needle in reducing method. In this way, the acupuncture after pulse diagnosis can regulate zang-fu organs and meridians, yin and yang, qi and blood, and promote blood circulation for removing blood stasis and resolving dampness, and attack the retained fluid and tumour in the liver, and combined with adjunct points to treat cancer.
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Focusing on the TCM-related adverse drug reactions, especially those conventionally non-toxic TCM induced hepatotoxicity, this paper has proposed and established the disease-syndrome-based toxicology evaluation pattern and approach for TCM, not only the normal rats, but the hepatic fibrosis model rat were studied hepatotoxic or hepatoprotective effects of rhubarb, meanwhile liver histopathology changes by histological tests such as HE and TUNEL staining. The metabolomics analysis method will be employed to screen the key metabolites and possible metabolic pathway of the dual effects of rhubarb in rats. The results showed that rhubarb could result in significant liver injury in normal rats, indicated by the elevation of plasma serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities (P L-arginine, creatine, L-valine, retinyl ester, and prostaglandin F2α were confirmed by multivariate statistical analysis and metabolic pathways enrichment analysis linked to six metabolic pathways, including taurine and hypotaurine metabolism, primary bile acid biosynthesis, arginine and proline metabolism, arachidonic acid metabolism, retinol metabolism and valine, leucine and isoleucine biosynthesis. In summary, the results suggested the dual effects of rhubarb screened by taurine and hypotaurine metabolism, primary bile acid biosynthesis and arginine and proline metabolism may be the key metabolic pathway related to You Gu Wu Yun phenomenon of rhubarb. This study will provide new vision and illustration of scientific evidences for the hepatotoxicity assessment and rational use of those drugs containing anthraquinones.
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[Objective] To study Yi Pian of Su Wenand its author. [Method] Using the method of documents index and collection and research to make comprehensive texual research onYi Pian of Su Wento prove the origin from the aspect of term and verb and rhetoric and so on. [Result]Yi Pian of Su Wenis the work after Tang Dynasty,quoting fromXuan Zhu Mi Yu.The rhetoric of it is not the usage before Han Dynasty,for example,black corps,green corps,red corps and so on.We can see the usage of Jia Ling in the work,which was begun fromShang Han Za Bing Lunrather than Nei Jing.The understanding of Yun Qi theory inherited from the theory of Wang Bing.Many therapeutic methods were created by LIU Wenshu instead of WANG Bing orNei Jing. LIU Wenshu wroteSu Wen Ru Shi Yun Qi Lun Aowhich was based on seven sheets of Yun Qi and the theory of WANG Bing,possessing the theory basis ofYi Pian of Su Wen.[Conclusion] Thus we regarded theYi Pian of Su Wenas the work of LIU Wenshu who had made a great contribution to the theory of Five Yun and Six Qi.Su Wen Ru Shi Yun Qi Lun Aoclarified the truth of Yun Qi by plotting,creating Gan Zhi Qi Yun and Si Tian Jue. LIU Wenshu made the theory of Tian Di Jia Zi ,which was founded inXuan Zhu Mi Yu,as the theoretical foundation of'transformation of plague in three years'.He developed the theory and put forward the treatment method.
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[Objective]To discuss the space-time background of Five Yun and Six Qi and know the historical background of Five Yun and Six Qi theory and the time and space span.[Methods] Using the method of literature studies to interpret space-time of Yun Qi theory using Nei Jing theory from the time and space background of Six Qi of Si Tian,60 Jia Zi,Sui Li,Four Seasons,Day and Night,Heaven and Earth,Five Orientations and so on.[Results]The theory of Five Yun and Six Qi consists of 60 Jia Zi and explores the movement rule of Five Yun and Six Qi,showing rules between the celestial motion,physioclimate and human life.The theory regards heaven and earth as the space background,exploring the relationship between physioclimate and life,holding that human lives on the Qi of heaven and earth.The operation of heaven and earth creates five orientations to match different weather.Regions vary because of different Qi of heaven and earth.The same region has different Qi of Yin and Yang because of high and low.[Conclusion]The theory of correspondence between man and universe is fully reflected in Time and Space which is the basis of the theory of Yun Qi in Nei Jing.
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Objective] To discuss the rule of operation of heaven and earth on the basis of Five Yun and Six Qi and explore the importance on Yun Qi theory. [Method] Using the method of literature studies to explore the rule of Yun Qi theory and operation of heaven and earth. [Result] The theory of Five Yun and Six Qi holds the idea that the Qi of heaven and earth is athletic and the movement is regular.Five Yun concludes Big Yun and Small Yun.Big Yun is Sui Yun,five years a cycle according to the order of‘ wood,fire,earth,gold,water’.Six Qi concludes six steps and moves in circles.Heaven Qi goes left and Earth Qi goes right.The forms of motion concludes QiJiao movement,Sui Yun up and down and so on.Whether the form is normal or not relates much to the nature climate and the human morbidity.[Conclusion ]The theory of Five Yun and Six Qi shows the rule of climate created by the operation of heaven and earth.The regular movement of Five Yun and Six Qi varies a lot,making impact on nature climate and the human morbidity,which is the incisive meaning of the theory of Five Yun and Six Qi in Nei Jing.
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“Pushing meridians to treat viscera diseases” by Xiangxi Liu’s infantile tuina in treating infantile enuresis is based on the related meridians-viscera, the generation-inhibition of five elements as well as the infantile physiological and pathological characteristics, utilizing the theory of“pushing the five meridians, adjusting the five viscera”. Specific reforcing and clearing (reducing) operation and frequency of operation are determined by the syndrome differentiation, with the purpose of cureness.
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[bjective]The paper summarizes the academic thoughts and clinical experience of Professor HAN Xinmin for treating Hp related anorexia in preschool children.[Methods] By learning from Professor HAN Xinmin, recording the relevant cases and analyzing typical cases, to sum up the knowledge of etiology and pathogenesis, treatment characteristics, as well as list one proved case.[Results] Professor HAN Xinmin holds that this disease is caused by exogenous damp heat, and the pathogenesis is damp heat invading the spleen and stomach. There are two kinds of syndromes: dampness heat trapping spleen and spleen deficiency dampness retention. The treatment emphasizes the clearing away heat and dampness and moving the spleen for good appetite. Huo Pu Xia Ling Decoction and Yun Pi Kai Wei Decoction have achieved a satisfactory clinical curative effect. [Conclusion] Therapies of Professor HAN Xinmin in treating Hp related anorexia in preschool children have significant effect, which has the value of popularization and application.
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Objective] To discuss the calendar background of Five Yun and Six Qi and know the background basis of Five Yun and Six Qi from the calendar feature of “ Nei Jing”. [Methods ] Using the method of documents index and collection and research to explore the form of calendar and the relationship between the manifestation mode and Five Yun and Six Qi in “ Nei Jing”, application of Yun Qi theory. [Results] The ancient calendar was created on the basis of astronomical phenomena,showing the change rule of the universe.The calendars in “ Nei Jing”conclude Taichu,Sifen,October Taiyang.Yun Qi theory flexibly uses the October Taiyang which is unified with Taichu and Sifen.The ways “ Nei Jing” display calendar are criterion measurement,clepsydra measuring time,sixty Jai Zi and so on.[Conclusion ]Five Yun and Six Qi built on the basis of calendar Taichu, Sifen, October Taiyang and the interpretation of calendar background has great significance on the study of Yun Qi theory.
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Objective To explore the effects of Xuan Yun Ning on the plasma endothelin in pafients with vertebrobasilar ischemia.Methods 60 cases of vertebrobasila ischemia were randomly recruited into a treatment group and a control group,with 30 cases in each group.The control group was treated with Nimodipin,and the treatment group was treated with Xuan Yun Ning plus Nimodipin.Another 30 healthy persons whose age is more than 40 years were recruited for a healthy control group without any treatment The alterations of plasma endothelin were measured by radiation immunological test in the treatment group,the control group,and the healthy control group.Results The elevated plasma endothelin was significantly decreased in treatment group than the control group and the healthy control group(P＜0.05).Conclusion Xuan Yun Ning improves the blood volume by lowering the level of plasma endothelin and thus treats patients with vertebrobasilar ischemia.
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Yun Ti Wang studied medicine in England, different from other Korean medical doctors in early days. Yun, who entered medical school at Glasgow University in England in March 1919, graduated with a Bachelor of Medicine in October 1925, along with an England medical license. Yun began working as an instructor at Severance Medical College from November 1927, and received Doctor of Medicine from the College of Obstetricians and Gynecologists at Kyoto Imperial University in August 1936. After the Liberation, Yun began working as a faculty member at the medical school at Seoul University, and he also worked as a Chief of the Second Medical Clinic of the school from 1946. Yun made a great effort in order to build an integrated committee, eventually contributing to the launching of Joseon Medical Associates in 1947. He was also elected as a first president at Joseon Obstetrics and Gynecology Associates, which was organized at the same year as the Joseon Medical Associates. Yun entered military as an army surgeon in April 1949 and has worked there until he was appointed as a principal at the Army Medical School in September 1953. His contributions to the development of military medical services include the following: expansion of medical facilities in army, stable system of workforce in military medical service, launching of Medical Aid and establishment of Department of Medical Care, and introduction of new medical technologies in anesthesiology and neurosurgery, etc. The career of Yun can be largely divided into the field of gynecology and military medical services. In the gynecological field, Yun contributed to the settlement of obstetrics in Korea, by taking in charge of the obstetrics class at Severance following medical missionaries. As for the military medical services, he has contributed to the establishment of military medical system as well as to the opening of new academic areas. The impact of his activities on the establishment of military medical services is especially significant, since it was a field that no Korean citizens had access to during the colonization era.
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Education, Medical/history , England , Gynecology/history , History, 20th Century , Korea , Military Medicine/history , Obstetrics/history , Societies, Medical/historyABSTRACT
[Objective] Study effect of Yun-Pi Prescription on regulating the immune function,approach the mechanism of Yun-Pi Prescription on how to enhance immune function.[Method]All the mice were divided into groups: the normal group,the model group,the positive control group treated with Xiao Shi Jian Er Syrup,and Yun-Pi Prescription treatment groups including high,middle and low dose;determine the index number of immune organ,phagocytic count and phagocytize activity of normal mice.[Results]The high and middle dose of Yun-Pi Prescription can obviously enhance the phagocytic count and phagocytize activity,Yun-Pi Prescription has an up-regulation effect on immune function.
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Objective To investigate the effects of Yun-Pi Prescription on hemolysin antibody,and approach its mechanism of regulating immune function.Methods Forty-eight KM mice were randomly divided into high,medium and low dose of Yun-Pi Prescription groups,which were given 20,10,5 mL/kg Yun-Pi Prescription respectively,and one control group with no intervention.From the seventh day,all groups were injected with chicken red blood cell for seven days.Levels of serum hemolytic optical density were measured in all groups.Results Compared with control group,levels of serum hemolytic optical density in Yun-Pi Prescription groups increased significantly(P
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[Objective] To observe the effects of Yun-Pi Prescription of different doss on endurance of rats with splenic asthenia and to explore the mechanism of Yun-pi Prescription in treatment of children apositia.[Methods] To set up the animal model of splenic asthenia with reserpine.Experimental rats were randomly divided into six groups:the control group,the model group,the positive control group.Xiao Shi Jian Er Syrup,and Yun-Pi Prescription treatment groups including high,middle and low dose.Changes of body weight,food intake and swimming time were measured to determine the endurance of rats.[Results] Yun-Pi Prescription could increase body weight and food intake,prolong the swimming time of splenic asthenia rats.[Conclusion] Yun-Pi Prescription could effectively counteract fatigue and improve endurance of rats with splenic asthenia and it is useful in treatment rats with splenic asthenia.