ABSTRACT
Objective: To study the chemical structure and bioactivity of the alkaloids from Zanthoxylum schinifolium. Methods The alkaloids were isolated and purified by silica gel, Sephadex LH-20 column chromatography, recrystallization, and semi-preparetive HPLC. Their structures were elucidated by physical and spectroscopic analysis. The cytotoxic activity of these compounds were tested by MTS. Results Nine alkaloids were obtained and identified as dictamnine (1), skimmianine (2), schinifoline (3), 6-methoxy-furanoquinolone (4), (+)-(S)-isoplatydesmine (5), (+)-(S)-araliopsine (6), (−)-(S)-ribalinine (7), (−)-(S)-edulinine (8), and (−)-(S)-6-acetonyldihydrochelerythrine (9). Conclusion Compound 4 is a new natural product and compounds 5—9 are isolated from this plant for the first time. Compound 9 has potential cytotoxicity towards HL-60, SMMC-7721, and A549.
ABSTRACT
There are more than 50 species of Zanthoxylum (Rutaceae) plants in China, which are very important Chinese meteria medica and natural medicines. It has a variety of pharmacological activities, among which one of the important activities is to inhibit the growth of pathogenic microorganisms and parasites, which can be used as the source of anti-infection drugs. This paper reviews the progress on anti-infective activities of the plants of genus Zanthoxylum in recent years, covering infectious pathogens from bacteria, fungi, viruses to parasites, in order to provide references for the search of novel structural compounds and antiinfective drugs with new mechanisms.
ABSTRACT
Objective To study the chemical constituents of Zanthoxylum dimorphophyllum and identify the chemical structures.Methods The compounds were isolated by silica gel,Flash column chromatography and purified by crystallization.Their structures were elucidated by spectral methods.ResultsSeven compounds were isolated and identified.They are 6-(3′,methyl-2′,3′-dihydroxy) butyl-7-methoxyl-8-(3″-methyl-2″-butenyl)-coumarin(Ⅰ),8-(3′-methyl)-2′,3′-butenyl-2′-(1″-hydroxy-1″-methyl)-ethyl-6,7-dihydrofurancoumarin(Ⅱ),6,7,8-trimethoxycoumarin(Ⅲ),scoparone(Ⅳ),umbelliferone(Ⅴ),canthin-6-one(Ⅵ),and syringaresinol(Ⅶ).Conclusion Compound I is a novel compound and all compounds are obtained from Z.dimorphophyllum for the first time.