ABSTRACT
AIM: To study the effects of Zhongjingweiling Capsule (Fructus Amomi, Cortex Cinnamemi, Rhizoma Alpiniae Galangae, Fructus Foeniculi, Radix Glycyrrhizae, etc.) on analgesia, anti inflammation and gastrointestinal peristalsis inhibition. METHODS: The effect of analgesia was tested by the method of writhes and hot plate on mice. The effect of anti inflammation was tested by injecting acetic acid and implanting cotton pellet and xylene into mice. RESULT: Zhongjingweiling Capsule effectively inhibited the swelling of mouse pinna induced by xylene and the increase of peritoneal capillary permeability caused by the acetic acid injected into mice. The capsule also decreased the proliferation of granuloma caused by implantation cotton pellet significantly and had an abirritant effect on the algesia induced by acetic acid and hot plate. Besides, it effectively inhibited the gastrointestinal peristalsis. CONCLUSION: Zhongjingweiling Capsule is an effective medicine in anti inflammation, analgesia, and gastrointestinal peristalsis inhibition.
ABSTRACT
Objective: To study the action of Zhongjiangweiling Capsule (Fructus Amoni, Cortex cinnamoni, Rhizoma Alpiniae officinarum Radix Glycyrrhizae) on the experimental gastric ulcer. Methods: Area of ulcer, gastric juice volume, acidity and pepsin output were measured on experimental gastric ulcer models induced by the ligated pylorus and burned acetic acid and i.p Reserpine in rats. Results: Zhongjingweiling Capule showed to be able to reduce areas of ulcers, gastric juice volume, acidity and pepsin output. Conclusion: Zhongjingweiling Capsule had antiulcer effect in rats.