Clinical analysis of gum bleeding caused by acquired factor XIII deficiency disease / 实用口腔医学杂志

Acquired factor XIII deficiency disease is rare.One case with gum bleeding as the first symptom caused by acquired factor XIII de-ficiency disease was encountered.The case was analyzed and relevant literatures were reviewed.

Síndrome de anticuerpos antifosfolípidos asociado a la presencia de inhibidor adquirido del factor IX en una paciente sin hemofilia / Antiphospholipid antibody syndrome associated with acquired factor IX inhibitor in a non-hemophilic patient

Se presenta el caso de una paciente de 23 años de edad, con diagnóstico de síndrome de anticuerpos antifosfolípidos, con un cuadro típico de trombosis venosa profunda recurrente y pérdidas fetales, en presencia de anticoagulante lúpico y anticuerpos anticardiolipina positivos. En el transcurso de su enfermedad presenta manifestaciones hemorrágicas, no explicadas por el uso de anticoagulantes orales. Los estudios de hematología permitieron documentar una disminución de los factores IX y VIII, con evidencia de inhibidor específico del factor IX. La deficiencia de factores de la coagulación mejoró gracias al uso de esteroides y ciclofosfamida. (Acta Med Colomb 2011; 36: 196-199).

We report the case of a 23-year-old female patient with an antiphospholipid syndrome characterized by recurrent deep venous thromboses and fetal losses, with positive lupus anticoagulant and anticardiolipin antibodies. During the course of the disease she had hemorrhagic manifestations not attributable to oral anticoagulants. Hematological analyses documented reduced levels of factors IX and VIII, with evidence of a specific inhibitor of factor IX. The deficiency of clotting factors improved with steroids and cyclophosphamide. (Acta Med Colomb 2011; 36: 196-199).

The Pathogenesis of Cerebral Arteriovenous Malformations / 国际脑血管病杂志

Cerebral arteriovenous malformation is a common cerebrovascular disease.Its exact pathogenesis remains unclear.At present,it is thought that this disease is caused by kinds of factors,including congenital and acquired factors.