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Establishing a scientific method of quality control and evaluation of Chinese materia medica (CMM) is important and challenging for ensuring the safety and effectiveness of CMM. The existing methods of quality control and evaluation of CMM have many limitations and it can not be effectively evaluated in the true sense. Based on the existing CMM quality system, the rational use of bioeffect evaluation method can realize the scientific quality control and evaluation of CMM and provide the necessary technical support for the modernization of CMM. This article summarizes the bioeffect evaluation methods established in CMM, such as activating blood and removing stasis, ventilating lung, antibacterial activity, and anti-inflammatory activity. This paper provides useful reference for establishing a scientific quality control and evaluation system of CMM.
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Objective To study the effects of ultrafiltration process on activating blood and removing blood stasis efficacy ofShentong Zhuyu Decoction; To investigate the feasibility of applying ultrafiltration technology in purifying Shentong Zhuyu Decoction.Methods The mice micro artery and vein diameter, clotting time and opening capillary of auricle microcirculation of mice were used as indexes to observe the effects of different ultrafiltration process on activating blood and removing blood stasis efficacy ofShentong Zhuyu Decoction.ResultsShentong Zhuyu Decoction showed satisfying efficacy of activating blood and removing blood stasis. There was no significant difference between the non-ultrafiltration process and ultrafiltration processed by 20 and 50 nm ultrafiltration membranes.Conclusion Ultrafiltration technology can be applied to purifying Shentong Zhuyu Decoction, and the membrane pore size must be more than 20 nm.
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To review and summazie the literatures of clinical studies using promoting blood circulation to remove blood stasis for the patients with PSD in the past five years. The TCM treating principles of promoting blood and Qi circulation, promoting blood and nourishing blood flow, promoting blood and benefiting Qi, promoting blood and eliminating phlegm have showed their beneficial clinical effect and few adverse reactions. It provided good ideas for the treatment of PSD.
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[Objective] To observe the effect of Xiangdan injection with the actions of activating blood and removing stasis for the treatment of acute tubular necrosis (ATN) after kidney transplantation. [Methods] Twenty-six patients with ATN after kidney transplantation were randomized into groups A and B. The two groups were treated with triple immuno-suppressive agents of cyclosporin A, prednisone and mycophenolic acid, with medicines for protecting liver function and gastric mucosa, and with preventive measures from infection. Additionally, group A (n = 16) was treated with Xiangdan injection, while group B ( n = 10) was not. After treatment, time for hemodialysis, renal function and renal flow resistance index of the transplanted kidney were compared between the two groups after the occurrence of ATN. [Results] Compared with group B, time for hemodialysis was shortened, the decrease of serum creatine (SCr) in the transplanted kidney quickened, and renal flow resistance index (RI) of the transplanted kidney decreased (P 0.05). [Conclusion] Xiangdan injection with the actions of activating blood and removing stasis can promote the early recovery of ATN after kidney transplantation.
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[Objective] To investigate the synergistic action of fuming-washing therapy with Qingbixifang ( a herbal lotion mainly composed of Herba Siegesbeckiae, Cortex Phellodendri, Radix Paeoniae Rubra, Radix Rehmanniae, Radix Stephaniae Tetrandrae, Rhizoma Atractylodis, Herba Ecliptae, Nidus Vespae, Olibanum, Myrrha, etc.) on rheumatoid arthritis (RA) with heat retention. [Methods] Sixty patients of RA with heat retention were randomized into groups A and B. Group A ( n = 30) was treated by fuming and washing the affected part with Qingbixifang, and taking Tongbiling Tablets and nimesulide; group B (n = 30) was treated by taking Tongbiling Tablets and nimesulide only. The treatment course of the two groups lasted one month. The time of morning stiffness, grip strength, the number of joints with tenderness, tenderness index, resting pain in joints, the number of swelling joints, swelling index, evaluation by patients themselves and by the doctor were compared before and after treatment. Laboratory parameters such as blood rheumatoid factor (RF), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell (WBC) count and platelet (PLT) count were also observed before and after treatment. [Results] The total effective rate was 90.0% in group A and 66.7% in group B, the difference being significant (P
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[Objective] To observe the therapeutic effect of wind-dispersing and cold-dispelling, blood-activating and stasis-removing therapy for cold-type urticaria and to explore its possible mechamism. [Methods] Sixty-six cases were allocated to two groups by a simple random sampling method. Group A ( n = 36) was treated with wind-dispersing and cold-dispelling, blood-activating and stasis-removing herbal medicine including Herba Ephedrae, Ramulus Cinnamomi, Herba Schizonepetae, Radix Saposhnikoviae, Semen Armeniacae Amarum, Rhizoma Zingiberis Recens, Fructus Jujubae, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Caulis Spatholobi, Radix Paeoniae Rubra, etc. Group B (n =30) was treated with cetirizine hydrochloride tablets. The two groups were treated for two 20-day courses. One week after treatment, the therapeutic effect and the changes of hemorheological parameters before and after treatment were observed and compared with those in 38 healthy volunteers. [Results] The total effective rate was 80.6% in group A and 63.3% in group B, the difference being significant ( P 0.05) . [ Conclusion] Wind-dispersing and cold-dispelling, blood-activating and stasis-removing therapy is an important method for cold-type urticaria and the selected herbal medicines are effective. Its therapeutic mechanism may be related to the improvement of hemorheological parameters.
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0.05).The differences of comprehensive scoring of QOL and scoring of factors 1,2,3 and 4(F_1,F_2,F_3 and F_4)in group A were significant as compared with those before treatment(P0.05),indicating that oral use of SRTT inhibited the aggravation of pulmonary function.The improvement of QOL in group A was superior to that in group B after treatment and the difference was significant(P
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[Objective] To observe the therapeutic effect of Ganxian Granules Ⅰ (mainly composed of Radix Stephani-ae Tetrandrae, Semen Persicae and Radix Notoginseng) for the treatment of liver fibrosis induced by chronic virus hepatitis. [Methods] Two hundred cases of liver fibrosis induced by chronic virus hepatitis were randomized into group A (n = 120) and group B ( n = 80). Group A received Ganxian Granules Ⅰ 10g per day, tid, and group B received Dahuang Zhechong Pills 9g per day, tid for half a year. The therapeutic effect in the two groups was evaluated after treatment. The changes of hepatic function and serum levels of hyaluronidase (HA) , laminin (LN) and type Ⅲ precolla-gen ( PC Ⅲ) were compared before and after treatment. Meanwhile, type B ultrasonographic results and hepatic pathologic features were observed. [Results] The total therapeutic effective rate was 87.5% in group A, higher than 70.0% in group B ( P 0.05). Group A had a better effect in improving the hepatic function than group B (P
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[Objective] To investigate the therapeutic effect of Guanxin No. 1 Recipe (mainly composed of Radix Codonopsis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Rhizoma Polygonati Odorati, Rhizoma Chuanxiong, Rhizoma Anemarrhenae, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Curcumae) for coronary heart disease (CHD) with angina pectoris (AP) and to observe its influence on blood lipid and hemorrheology indexes. [Methods] Eighty-eight patients with AP were allocated to group A (n = 48) and group B (n = 40) according to random number table. The two groups were given isosorbide dinitrate, Metoprolol Tartrate Tablets and enteric-coated aspirin tablets, and group A was treated with Guanxin No. 1 Recipe additionally. Four weeks constituted one treatment course. The effects on TCM syndromes, AP, electrocardiogram (ECG) and symptoms scoring, as well as on blood lipid level and hemorrheology indexes were observed before and after treatment. [Results] After treatment, the effects on TCM syndromes, AP, electrocardiogram and symptoms scoring in group A were superior to those in group B (P 0.05) . Whole blood high-shear viscosity (WBHSV) and whole blood low-shear viscosity (WBLSV) were decreased in the two groups (P 0.05). [Conclusion] Guanxin No. 1 Recipe has a better effect on relieving symptoms and improving EGG in CHD with AP, and this may be related to the decrease of blood lipid level and improvement of hemorrheology index.
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Objective To assess the therapeutic effect and safety of Chinese medicine with the actions of activating blood and removing stasis in the treatment of acute coronary syndrome(ACS)patients.Methods Sixty-six patients with ACS were randomly assigned to the control group,the Danshen Injection(DI) group and the DI combined with Chuanxiongzine Injection(CI) group.All of the three groups received antithrombotic therapy besides the corresponding medicine according to the experimental design.The therapeutic effect and safety of the three groups were observed and compared after treatment.Results The hemorheology of ACS patients in the three groups was improved(P
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Objective To explore the clinical effect of Jiangru Formula(Herbal formula for soothing the liver,clearing heat,activating blood and removing stasis)combined with TCM surgical treatment for plasmocyte mastitis.Methods Fifty five patients with plasmocyte mastitis were treated with Jiangru Formula orally and TCM surgical treatment to see the effect of this method.Results The total effective rate was 100%.The average treatment period was(28?13.61)days.The recurrence rate was 1.82%.Conclusion The combination of Jiangru Formula with TCM surgical treatment for plasmocyte mastitis is effective in shortening the treatment period,reducing the recurrence rate and keeping the shape of the breast.