ABSTRACT
OBJECTIVE:To investigate clinical efficacy and safety of Xingnaojing injection in the treatment of acute cerebral infarction,and its effects on neurological function,activities of living,inflammatory factors and coma score.METHODS:Ninety patients with cerebral infarction admitted in Chongqing People's Hospital from Jun.2015 to Jan.2016 were divided into control group and observation group according to random number table,with 45 cases in each group.Control group was given conventional treatment as Clopidogrel bisulfate tablets 75 mg,po,qd+ Nimodipine tablets 20 mg,po,tid.Observation group was additionally given Xingnaojing injection 20 mL added into 0.9％ Sodium chloride solution 250 mL,ivgtt,qd,on the basis of control group.Both groups received treatment for consecutive 14 d.Clinical efficacies of 2 groups were observed.NIHSS scores,Barthel indexes,Glasow coma scale and the levels of TNF-α and IL-6 were also observed before and after treatment.The occurrence of ADR was recorded.RESULTS:The total response rate of observation group (91.11％) was significantly higher than that of control group (73.33 ％),with statistical significance (P＜0.05).Before treatment,there was no statistical significance in NIHSS scores,Barthel indexes,Glasow coma scale or the levels of TNF-α and IL-6 between 2 groups (P＞0.05).After treatment,NIHSS scores,the levels of TNF-α and IL-6 in 2 groups were decreased significantly,while Barthel indexes were increased significantly;the improvement of above indexes in observation group were significantly better than control group,with statistical significance (P＜0.05).Fourteen days after treatment,Glasow coma scale of control group was significantly higher than before treatment;1,5,14 d after treatment,Glasow coma scale of observation group was significantly higher than before treatment,and significantly higher than that of control group,with statistical significance (P＜0.05).Total incidence of ADR in observation group (6.67％) was significantly lower than control group (13.33％),with statistical significance (P＜0.05).CONCLUSIONS:Xingnaojing injection shows significant therapeutic efficacy for acute cerebral infarction,can effectively improve the neurological function,activities of living,the regain of consciousness,and can reduce the level of inflammatory factor with good safety.
ABSTRACT
Objective To explore the effects of microsurgical technique treatment on acknowledge ability ,activities of daily liv-ing ,cortex blood perfusion and neuropeptide levels of brain glioma patients .Methods Microsurgical technique treatment and tradi-tional operation were given to 87 brain glioma patients ,respectively .The acknowledge ability and activities of daily living were measured by HDS ,MMSE and ADL ;the cortex blood perfusion were revealed by PET ,and the neuropeptide levels including argi-nine vasopressin ,oxytocin ,β-endorphin ,somatostatin and neurotensin of patients from two different surgical groups were compared . Results As compared with the traditional operation ,the acknowledge ability and activities of daily living of patients from microsur-gical treatment group were significantly improved(P<0 .05) ,the cortex blood perfusion were statistically increased (P<0 .05) and the levels of five kinds of neuropeptide were all profoundly increased (P< 0 .05) .Conclusion Microsurgical technique treatment could improve the acknowledge ability and activities of daily living of brain glioma patients ,the mechanisms of which could be the increase of cortex blood perfusion and theincrease of neuropeptide levels .