ABSTRACT
Objective:To explore the role ofprostaglandin E2 (PGE2) and epidermal growth factor (EGF) in the protective effect ofpolaprezinc on acute gastric mucosal damage.Methods:A total of 30 male SD rats were randomly divided into 3 groups as follows:A blank group,a model group,and a polaprezinc group.The blank group was fed normally.As for the model group and the polaprezinc group,the rats were given 1 mL ethanol (intragastrical administration) first,then they were treated with vehicle (1 mL distilled water) or polaprezinc treatment (100 mg/kg) 1 h later.On the 3rd day,rats in each group were fasting for 24 h before gastric administration.After 2 h of gastric administration,5 mL of intraperitoneal blood was collected,centrifuged and stored at-80 ℃ for the detection of EGF and PGE2.Gastric tissue was collected for anatomic and pathological assessment.Results:Polaprezinc reduced gastric mucosa injury in the polaprezinc group compared to the model group.Compared with the blank group,the levels of PGE2 and EGF in blood serum were significantly decreased in the model group and the polaprezinc group (P＜0.05),while there was no significant difference between the model group and the polaprezinc group (P＞0.05).Conclusion:Polaprezinc can provide effective protection for acute mucosal injury and the underlying mechanism is not directly related to PGE2 and EGF.
ABSTRACT
Infectious mononucleosis is an EBV-induced infection, and this is a self-limiting clinical syndrome with such characteristics as fever, pharyngitis, headache, splenomegaly, hepatomegaly and multiple lymphadenopathy among children and young adults. On the other hand, EBV infection-induced gastrointestinal symptoms like anorexia, nausea, vomiting, dyspepsia, abdominal pain, gastric bleeding and diarrhea are non-specific signs and there is less of a chance of EBV infection being involved with gastrointestinal disease. Especially, the relation of gastric cancer and gastric lymphoma with EBV infection is well defined, but other EBV-related gastrointestinal diseases have rarely been reported. Therefore, we report here on a case of acute erosive EBV gastritis that was diagnosed as EBV-induced infectious mononucleosis, and this was confirmed by esophagogastroduodenoscopy with biopsy.
Subject(s)
Child , Humans , Young Adult , Abdominal Pain , Anorexia , Biopsy , Diarrhea , Dyspepsia , Endoscopy, Digestive System , Epstein-Barr Virus Infections , Fever , Gastritis , Gastrointestinal Diseases , Hand , Headache , Hemorrhage , Hepatomegaly , Herpesvirus 4, Human , Infectious Mononucleosis , Lymphatic Diseases , Lymphoma , Nausea , Pharyngitis , Splenomegaly , Stomach Neoplasms , VomitingABSTRACT
Infectious mononucleosis is an EBV-induced infection, and this is a self-limiting clinical syndrome with such characteristics as fever, pharyngitis, headache, splenomegaly, hepatomegaly and multiple lymphadenopathy among children and young adults. On the other hand, EBV infection-induced gastrointestinal symptoms like anorexia, nausea, vomiting, dyspepsia, abdominal pain, gastric bleeding and diarrhea are non-specific signs and there is less of a chance of EBV infection being involved with gastrointestinal disease. Especially, the relation of gastric cancer and gastric lymphoma with EBV infection is well defined, but other EBV-related gastrointestinal diseases have rarely been reported. Therefore, we report here on a case of acute erosive EBV gastritis that was diagnosed as EBV-induced infectious mononucleosis, and this was confirmed by esophagogastroduodenoscopy with biopsy.