Progress of laboratory diagnosis of acute pancreatitis in children / 国际儿科学杂志

The traditional laboratory markers of acute pancreatitis in children include serum amylase and urine amylase, serum lipase, urinary trypsinogen-2, C-reactive protein, cytokines, amylase and creatinine clearance ratio and so on. They can be simply detected and economic, but the sensitivity and specificity are not satisfied. Several new laboratory markers of acute pancreatitis in children, which include procalcitonin, phospholipase A2, PankrinTM, trypsinogen activation peptide, carboxypeptidase B activation peptide, human pancreas-specific protein/procarboxypeptidase B, polymorphonuclear elastase, serum amyloid protein A, and as well as intercellular adhesion molecule- 1, have been found and applied in recent years .They can provide reliable judgment methods for early diagnosis and prediction of the severity of acute pancreatitis in children, but most of the new laboratory markers are rarely used in clinic because they are difficult to be detected and expensive. More sensitive, specific, cheap and operable laboratory markers which can be used in clinic are to be explored.

Tissue pharmacology of recipe-A new hypothesis / 中草药

The pharmacological characteristics of recipes are multi-components, multi-ways, multi-links, and multi-targets, on which the efficacy substances in recipes are worth of studying. To explore the essential substances of Chinese herbs in recipe is one of the key points for modernization of Chinese materia medica. The pharmacological effects and bioactivities inside the target tissue of lesion body are still not clear, even though there are some progress in herb serum pharmacology, recipe pharmacokinetics, and pharmacodynamics. The main effective components of recipe to pancreas in acute pancreatitis models by ig or enema were investigated by HPLC-MS method so as to establish a new hypothesis (tissue pharmacology of recipe): i.e. guided hy fundamental theory of traditional Chinese medicine to study the effect and the mechanism of recipe's essential substances on target tissues with pharmacological methods; to establish the experimental method for searching the foundation, the principle, and the direct substances of recipes which act on target tissues; to form more effective formula if possible, and to explore in a new researching field for the recipes of Chinese materia medica.