ABSTRACT
Objective To research and make one kind of sealant gel to prevent glue from leaking effectively,and protect vascular anastomosis site,raise the vascular anastomosis patency.Methods The experiment was carried out based on theory and methods in chemistry;According to the membrane performance,the membrane water solubility,and other characters,the author took experiment on the alginic acid sodium,chitsan,the gelatin and other biological materials.Results Through the experiment by membrane performance,the alginic acid sodium met the requirement,which became the membrane with the CaCl2 reaction at once.Its membrane was not dissolved in the water.And the characters of its 1%-3% solution were good on fluidity and surface contact angle determines.The biological compatibility of the compound of it with 20% CaCl2 solution was good.Conclusion The characters of the composition,which is double component sealant made from 1-3% alginic acid sodium and 20%CaCl2 solution,is best in the biological experiment.Before new medical glue appeared in clinical,this gel is hopeful to be applied in clinic and provide theory basis for clinical anastomosis.