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ObjectiveTo analyze the clinical application characteristics of prescription preparations for external use in the Chinese pharmacopoeia 2020 edition （hereafter abbreviated as the Pharmacopoeia）. MethodThe topical functions， usage， dosage， dosage form， application method， and prescription of the preparations for external use in the Pharmacopoeia were analyzed. ResultThe Chinese pharmacopoeia 2020 edition includes a total of 138 prescription preparations for external use， the specific clinical usage， dosage， administration method， and efficacy evaluation of which remain unclear. These preparations can be used to treat a wide range of diseases. Specifically， the use in orthopedics and traumatology （36 preparations， accounting for 26.09%） is dominant， followed by that in internal medicine， surgery， and throat. The major application method is directly applying to the diseased area （35 preparations， 25.36%）. The main dosage forms are ointment （40 preparations， 28.99%） and powder （24 preparations， 17.39%） and others include liniments， suppositories， tinctures， and sprays. The clinical usage and dosage of these preparations are mostly unclear. Only 48 preparations （34.78%） are recorded with clear dosage and frequency of use， and 45 preparations （32.61%） have neither clear dosage nor frequency of use. The 138 prescription preparations for external use include 211 single medicines， of which 44 single medicines can be used alone. The single medicines are mostly used for heat clearing （48 preparations， 22.75%）. ConclusionThe Chinese pharmacopoeia 2020 edition （Volume I） records a large number of prescription preparations for external use， and the number shows an increasing trend. However， the usage， dosage， and efficacy evaluation criteria of these preparations remain to be improved and need in-depth research.
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Objective To analyze the clinical effect and the related performance of different tiotropium bromide in the treatment of adult asthma patients.Methods58 patients in the Second hospital of Shandong University from August 2014 to May 2016 admitted to the adult bronchial asthma, were randomly divided into observation group and control group, each of the 29 cases of patients, two patients were taken on the basis of routine treatment of tiotropium bromide in the treatment, the observation group in each given tiotropium 5 g treatment.The control group took a day sooner or later given tiotropium 2.5 g treatment, analysis of clinical effect of two groups were compared and the related performance.ResultsThis group of patients with different delivery methods after treatment, the observation group and the control group of arterial blood gas analysis results have significant difference compared to the clinical effect compared with statistical difference (P<0.05);treatment group the effective rate of treatment group and control the efficiency compared with significant differences (P<0.05);the two groups of patients after treatment, clinical symptoms were observed in groups of patients with asthma remission time were (6.24±1.92) d, while the control group was (8.33±2.47) d, the two groups were compared with statistical difference (P<0.05).ConclusionDifferent tiotropium dosing regimen for adult patients with asthma curative effect has significant clinical effect, compared with 5 per night given tiotropium Gtherapy and its clinical effect is more obvious.
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Abstract The aim of this study was to compare the administration of the Brazilian version of Early Childhood Oral Health Impact Scale (ECOHIS) questionnaire, applied by face-to-face and telephone format. A randomized sample of 76 parents/guardians of children up to 6 years old was selected in a Pediatric Dentistry Clinic of the Federal University of Santa Maria, Brazil. Patients were randomly selected for 2 different groups, according to administration sequence: F-T (Face-to-face-Telephone) and T-F (Telephone-Face-to-face). Two interviewers administered the ECOHIS questionnaire with 2 week interval between the methods. The reliability between sections of the different methods of administration was assessed by Cronbach's alpha and Intraclass Correlation Coefficient (ICC). There were differences in means of the ECOHIS between face-to-face and telephone methods. However, the value Cronbach's alpha were between 0.94-0.96, and value ICC ranged from 0.91-0.93, proving to be acceptable values. The Bland-Altman plots confirmed the results of reliability tests, supporting the accuracy of the methods. Although there is a slight difference in the scores, the use of both mode of administration of the ECOHIS yields reliable data when single method is used from the beginning to the end of the study. The results provided evidence to use either Face-to-face or Telephone method of administration of the ECOHIS
Resumo O objetivo deste estudo foi comparar a administração da versão brasileira do questionário Early Childhood Oral Health Impact Scale (ECOHIS), aplicado através de entrevista pessoal e por telefone. Uma amostra randomizada de 76 pais/responsáveis de crianças de até 6 anos de idade foi selecionada na Clínica de Odontopediatria da Universidade Federal de Santa Maria, Brasil. Os pacientes foram selecionados aleatoriamente para 2 grupos diferentes, de acordo com a sequência de administração: E-T (Entrevista Pessoal-Telefone) e T-E (Telefone-Entrevista Pessoal). Dois entrevistadores aplicaram o questionário ECOHIS com um intervalo de 2 semanas entre os métodos. A confiabilidade entre as seções dos diferentes métodos de administração foi avaliada pelo Alfa de Cronbach e Coeficiente de Correlação Intraclasse (ICC). Houve diferenças nas médias do ECOHIS entre os métodos de entrevista pessoal e telefone. No entanto, os valores de Alfa de Cronbach foram entre 0,94-0,96 e ICC entre 0,91-0,93, mostrando valores aceitáveis. O gráfico de Blant-Altman confirmou os resultados dos testes de confiabilidade, suportando a acurácia dos métodos. Embora exista uma pequena diferença nos escores, o uso de ambos os métodos de administração do ECOHIS produz dados confiáveis quando um único método é utilizado do início até o final do estudo. Os resultados forneceram evidências para usar tanto entrevista pessoal quanto por telefone como métodos de administração do ECOHIS.
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Humans , Male , Female , Child, Preschool , Child , Interviews as Topic , Oral Health , Telephone , BrazilABSTRACT
Objective The method of administration is one of the important factors influencing steroid-induced femoral head necrosis ( FHN) .From the perspective of administration compliance, time and persons needed, and pharmacodynamics, this study compared different administration methods for steroid-induced FHN in rabbits aiming to provide some experimental evidence for selec-ting correct methods of administration. Methods The steroid-induced femoral head necrosis rabbits ( New Zealand, male) were ran-domly divided into five groups according to the different administration methods of intervention:deep oral administration group (n=10), in-tragastric gavage administration group ( n =10 ) , free-drinking drug group (n=10) and model control group (n=5), blank control group (n=5), the administration compliance, administration time, mortal-ity, pharmacodynamic index of lipid content and empty lacunae rate were compared among deep oral administration group, intragastric ga-vage administration group, free-drinking drug group. Results Compliance effect size of deep oral administration group ( 1.78 ± 0.64) lower than intragastric gavage administration group (4.04 ±0.87) and free-drinking drug group (8.94 ±1.05) (P<0.01). Administration time among deep oral administration group ([0.94 ±0.02]min), intragastric gavage administration group ([9.47 ± 0.31]min) and free-drinking drug group ([889.50 ±235.38]min) overall comparison gradually increased (P=0.000), the differ-ence between the two groups was statistically significant (P<0.05).At the 2 and 4 weeks, cholesterol, triglycerides and low-density lipoprotein of deep oral administration group, intragastric gavage administration group, free-drinking drug group compared with model control group and blank control group the difference was statistically significant ( P<0.05) , and deep oral administration group com-pared with free-drinking drug group, the difference was also statistically significant ( P<0.05) .At the 2 weeks, empty lacunae rate of deep oral administration group ([15.44 ±2.68]%), intragastric gavage administration group ([15.02 ±3.34])%), free-drinking drug group ([16.72 ±4.06]%) compared with model control group ([18.59 ±3.12]%) and blank control group ([10.82 ± 2.76]%, the difference was statistically significant (P<0.05).At the 4 weeks, empty lacunae rate of deep oral administration group ([18.53 ±3.26]%), intragastric gavage administration group ([18.85 ±3.17]%), free-drinking drug group ([20.41 ±4.18]%) compared with model control group ([24.66 ±3.74]%) and blank control group ([11.37 ±2.23]%), the difference was also sta-tistically significant ( P<0.05 ) . Conclusion Compared with traditional methods of administration, deep oral administration has better compliance, shorter administration time, and similar to intragastric gavage administration in pharmacodynamics, but more effec-tive than free-drinking drug administration, and it is a new and effective method of administration.
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OBJECTIVE: To provide constructive suggestions aimed at the problems in the implementation of Prescription Administration Method(Method in short).METHODS: The problems were studied,the causes were analyzed and the countermeasures were discussed in light of the related state laws and codes as well as the present status and the basic national condition of prescription administration.RESULTS & CONCLUSIONS: The Method is insufficient in logic,standardization,rationality and compactness and lack in maneuverability.It is advisable to make explanations on the rules with the same legal effect or revise the rules according to the new conditions appeared after the implementation of the Method so as to achieve strict logic of certain contents,exactness in words,standardization,rationality,strictness,specific and maneuverability of clause and contents.