ABSTRACT
OBJECTIVE: To analyse the allergens in children with allergic rhinitis and provide evidence for the prevention and treatment of allergic rhinitis in children. METHODS: Allergens were detected in 2413 children with allergic rhinitis by immunoblotting from January 2013 to July 2018 in Department of Otolaryngology Head and Neck Surgery,Children's Hospital of Fudan University. RESULTS: The first four inhaled allergens were house dust mites,mixed mold,dog hair and house dust,each accounting for 49.52%,23.62%,17.99%,and 15.54%. The first four food-borne allergens were milk,eggs,cashews,and crabs,each accounting for 46.54%,22.92%,19.10%,and 9.45%. Most patients with allergic rhinitis(46.33%)have both inhaled and ingestive allergies.There was a statistically significant difference in the positive rate of allergens between male and female children(P<0.05). With age increasing,the positive rate of inhaled allergens in children gradually increased,and the positive rate of ingestive allergens gradually decreased. CONCLUSION: The inhaled allergens in Shanghai are mainly dust mites and mixed molds. The food-borne allergens are mainly milk and eggs. The detection of allergens can help to understand the allergic state of children.