ABSTRACT
OBJECTIVE:To study the hemostatic,antipruritic,and anti-crissal ulcer effects of Zhishuxi lotion.METHODS:The experimental animals were randomized into four groups(normal control group,Mayinglong-branded musk hemorrhoid ointment,Zhishuxi lotion high-dose group and low-dose group).The time needed to stop bleeding in all groups were tested by cutting mouse tail;the itch-threshold in each group of guinea pigs was determined by inducing itch with histamine phosphate;and the ulceration was observed by causing crissal ulceration in mice with acetic acid.RESULTS:Zhishuxi lotion could shorten the bleeding time,increase the itch threshold in guinea pig,and had some curative effect on acetic acid-induced crissal ulcer in mouse,as compared with the control group.CONCLUSION:Zhishuxi lotion has re-markable effects of hemostasis,itch-relief and anti-crissal ulceration.