ABSTRACT
Objective To investigate the clinical value of the procalcitonin (PCT)measurement in preventing the occurrence of the bacterial drug resistance and reducing the overuse of antibiotics.Methods 400 inpatients without thyroid dysfunction but with suspected bacterial infections in our hospital from June 2012 to April 2013 were screeded out.Under the patient′s informed consent and the allowable condition,the routine treatment group (200 cases )and the PCT guidance group(200 cases )were obtained. Then,the antibiotic use time,hospitalization duration and hospitalization expenses were retrospectively anlyzed in the two groups. Meanwhile,the PCT guidance group was dynamically monitored.Results The mean antibiotic therapeutic time in the PCT guidance group was shorter than that in the routine treatment group;the average hospitalization days had statistical difference between the two groups (P<0.001 );the antibiotic expenses accounted for 26.4% and 32.0% of the hospitalization medication costs,which also had statistically significant difference (P <0.001).The clinical pulmonary infection scores(CPIS)were not compared because of lacking microbiology indicators.During the dynamic monitoring,when PCT<0.10 ng/mL,the antibiotic use was stopped,when PCT≥0.25 ng/mL,the antibiotic use was restored,when PCT≥0.25 ng/mL or≥0.50 ng/mL for consecutive 3 d,adjusting the antibiotics,dose or administrating route obtained significantly therapeutic effect,which indicating that PCT could be used for the prognosis judgement of the disease.Conclusion The once measurement of serum PCT could guide for diagnosing and assessing the infection degree,while its continuous measurement could guide the antibiotic use and make the prognosis on the disease condition.
ABSTRACT
The aim of the paper is to review the research progress on the secondary metabolites from marine microorganisms in recent years and to summarize its application in antimicrobial activity. We have earched and collected the published articles which are focused on the secondary metabolites from marine microorganisms; analysed the structure and function of the secondary metabolites and summed up the antimicrobial activities of the production from marine microorganisms; in addition,investigated the mechanism of action about the antimicrobial activities of the secondary metabolites from marine microorganisms. The secondary metabolites from marine microorganisms have rich structural diversity and different mechanisms of action. Marine microorganisms have the potential to produce large numbers of bioactive metabolites, among which the antimicrobial substance is the most prominent,making it an important resource in the development of novel marine drugs.
ABSTRACT
The aim of the paper is to review the research progress on the secondary metabolites from marine microorganisms in recent years and to summarize its application in antimicrobial activity. We have earched and collected the published articles which are focused on the secondary metabolites from marine microorganisms; analysed the structure and function of the secondary metabolites and summed up the antimicrobial activities of the production from marine microorganisms; in addition, investigated the mechanism of action about the antimicrobial activities of the secondary metabolites from marine microorganisms. The secondary metabolites from marine microorganisms have rich structural diversity and different mechanisms of action. Marine microorganisms have the potential to produce large numbers of bioactive metabolites, among which the antimicrobial substance is the most prominent, making it an important resource in the development of novel marine drugs.
ABSTRACT
OBJECTIVE:To explore the rational use of antibiotics in patients undergoing laparoscopic cholecystectomy(LC) METHODS:The antibiotic use in the selected operation patients was retrospectively studied 230 patients were divided into four groups A group:Perioperative administration of drug;B group:Preoperative administration for 3 to 7 days and perioperative administration;C group:Perioperative administration and postoperative administration for 2 to 7 days;D group:Preoperative administration for 2 to 7 days,perioperative administration and postoperative administration for 2 to 7 days Four groups were compared about the efficacy,length of hospital stay and hospitalization expenses RESULTS:There were no significant differences in efficacy among A,B,C,D and in average length of hospital stay and hospitalization expenses between A and D groups A group was the lowest in two indices and had the best cost-effectiveness ratio CONCLUSION:There is clinical significance of preventive antibiotic application in LC patients;perioperative use is the best choice;Cefazolin is the first choice