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Objective To investigate the diagnostic value for rheumatoid arthritis(RA) by using combined detection of anti‐cy‐clic citrullinated peptide antibody (anti CCP ) ,anti keratin antibody (AKA ) and the antiperinuclear factor (APF ) in serum . Methods A total of 110 RA patients(RA group) ,50 patients with other autoimmune diseases(non RA group) and 110 healthy subjects (control group) were enrolled in the study .The concentrations of AKA ,APF were detected by using indirect immunofluo‐rescence assay and anti CCP by using ELISA .Results The positive rates of anti‐CCP ,AKA ,APF in RA group were higher than those in non RA group and control group(P<0 .05) .In the series detection of the three indicators ,the sensibility and specificity were 44 .55% and 99 .38% respectively ;in the parallel detection of the three indicators the sensibility and specificity were 93 .64%and 85 .63% respectively .Conclusion Anti CCP detection exhibits relatively higher sensitivity and specificity in the diagnosis of RA .Series detection of the 3 indicators can improve the specificity ,reduce the rate of misdiagnosis;parallel detection of the 3 indica‐tors can improve the sensitivity ,reduce the rate of misdiagnosis .The Combined detection of anti CCP ,AKA and APF has better di‐agnostic efficiency than single detection .
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OBJETIVO: Detectar anticuerpos circulantes contra seis infecciones transmisibles por sangre en donantes de una institución de seguridad social en Querétaro, México. MÉTODO: Se realizó un estudio transversal descriptivo retrospectivo con datos del Banco de Sangre del Hospital General Regional No. 1, del Instituto Mexicano del Seguro Social (IMSS). Se registraron 6 929 donantes, entre los cuales se identificó a los diagnosticados con cualquier anticuerpo circulante contra brucelosis, enfermedad de Chagas, hepatitis B, hepatitis C, sífilis y VIH. Los casos identificados con cualquiera de estas infecciones se analizaron según edad, género, estado civil, escolaridad, lugar de residencia y número de donaciones. Para estimar la prevalencia total se dividió el número de personas identificadas con cualquiera de los anticuerpos circulantes por el total de donantes, y luego por cada una de las diferentes infecciones. RESULTADOS: De los 6 929 donantes, 144 fueron detectados con algún tipo de anticuerpo circulante de las seis infecciones potencialmente transmisibles por sangre, lo cual da una prevalencia total de 2,07 por ciento (0-4,4). Las prevalencias más altas por tipo de anticuerpo circulante correspondieron a la hepatitis C, con 0,721 por ciento (IC 95 por ciento, 0,522-0,920), y a la enfermedad de Chagas, con 0,649 por ciento (IC 95 por ciento, 0,460-0,838). CONCLUSIÓN: La identificación de la prevalencia de donantes de sangre con anticuerpos circulantes de alguna de estas seis infecciones potencialmente transmisibles por vía sanguínea permite establecer un perfil epidemiológico propio del banco de sangre del Hospital General Regional No. 1. La enfermedad de Chagas se presenta como emergente, dando pauta a dirigir los esfuerzos para su control.
OBJECTIVE: To detect antibodies to six potentially blood-borne infections in blood donors at a social security institute in Querétaro, Mexico. METHODS: A cross-sectional, retrospective, descriptive study was performed using data from the blood bank records of the General Regional Hospital No. 1, Mexican Social Security Institute (IMSS). From the 6 929 registered donors, those with any antibody to brucellosis, Chagas' disease, hepatitis B, hepatitis C, syphilis, and HIV were identified. For the cases presenting any of these infections, the following demographics were analyzed: age, gender, marital status, education, home address, and number of donations made. To estimate overall prevalence, the number of donors with any of the antibodies was divided by the total donors, and then by each of the various infections. RESULTS: Of the 6 929 donors, 144 were detected with some type of circulating antibody of the six potentially blood-borne infections, with a total prevalence of 2.07 percent (0-4.4). The prevalence of blood donors with antibodies for hepatitis C was 0.721 percent (95 percentCI: 0.522-0.920) and Chagas' disease, 0.649 percent (95 percentCI: 0.460-0.838). CONCLUSIONS: Identifying the prevalence of blood donors with antibodies for any of these six, potentially blood-borne infections, allows the blood bank at the General Regional Hospital No. 1 to establish its own epidemiologic profiling. Chagas' disease proved to be emergent, calling for urgent control efforts.