ABSTRACT
Purpose:To study the efficacy and safety of combination of methylprednisolone (MP) and ondansetron (OND) in the prevention of acute and delayed nausea and emesis induced by cisplatin base chemotherapy. Methods:This was a randomized, self cross over study. 47 patients receiving cisplatin based chemotherapy were randomized to enter one of the two following groups:Group 1:the combination of 80mg MP and 8 mg OND were iv injected to the patients before the first cycle of chemotherapy and then 8 mg OND was iv injected to the same patients before the second cycle of chemotherapy (23 cases); Group 2:8mg OND was iv injected to the patients before the first cycle of chemotherapy and then the combination of 80 mg MP and 8mg OND were iv injected to the same patients before the second cycle of chemotherapy (24 cases). The dosage of chemotheraputic agents and the times of anti emesis agents were the same in the two different cycles of chemotherapy for each patient.Results:The complete and partial control of the acute emesis were significantly superior in the combination of MP and OND than in the OND alone(93.6% versus 70.2%, P