ABSTRACT
AIM To observe the effects of aqueous extract of Isatidis Radix (AEIR) on formation of hyperlipidemia in rats.METHODS Seventy-two male SD rats were randomly divided into six groups,normal control group,model group,AEIR low-dose (20 mg/kg),middle-dose (40 mg/kg),high-dose (80 mg/kg)groups and fenofibrate (20 mg/kg) group.Drugs were intragastrically administered for 40 days,body weights were recorded every five days.The rats in the normal control group were fed with ordinary diet,those in the other five groups were fed with high fat diet.At the end of experiment,the rats were killed,then ratio of fat weight to body weight,serum lipid level,LPL,HL,MDA and SOD were detected.The pathological changes of liver tissue were observed by light microscope.RESULTS AEIR significantly decreased body weight,fat weight and ratio of fat weight to body weight;significantly reduced the levels of TC,TG and LDL;significantly enhanced the activities of LPL and HL;significantly decreased MDA content and increased SOD activity in serum and liver tissue.Compared with the model group,the adipose degeneration of liver tissue in the various AEIR groups and fenofibrate group was improved.CONCLUSION AEIR can prevent the formation of hyperlipidemia in rats by regulating lipid metabolism.