ABSTRACT
Objective To establish a near infrared (NIR) quantitative model for the dissolution behavior of aripiprazole tablets. Methods The NIR spectra of aripiprazole tablets were collected and the dissolution tests were performed to determine the dissolution of each tablet at 3, 6, 9, 12, 15 and 30 min. The near infrared spectra regions of 4 000.00-4 396.90, 5 326.43-12 000.00 cm−1 were pretreated by Savitzky-Golay smoothing filter, and the dissolution behavior model was established by partial least squares method. Results The root mean square error of calibration (RMSEC) and the root mean square error of prediction (RMSEP) at different time points were analyzed. RMSEP was lower than 8%. The calibration correlation coefficient (RC) and the prediction correlation coefficient (RP) at different time points were above 0.95 (except for the point of 6 min). There was a good correlation between the NIR spectrum and the dissolution at each time point. Conclusion NIR spectroscopy could predict the dissolution behavior of aripiprazole tablets, which lays a foundation for online quality monitoring of tablets by NIR spectroscopy.
ABSTRACT
Objective To explore the clinical effect of Jieyu Anshen decoction combined with aripiprazole tablet in the treatment of chronic schizophrenia. Methods A total of 210 patients with chronic schizophrenia who were treated in our hospital from March 2015 to March 2017 were randomly divided into two groups,with 105 cases in each group. The control group was treated with aripiprazole tablet. The observation group was treated with Jieyu Anshen decoction combined with aripiprazole tablet. The treatment effect was observed and compared. Results There was no significant difference in the clinical condition between the two groups before treatment, and the improvement was more obvious in the observation group after treatment; The effective rate in the observation group (90.47％) was significantly higher than in the control group (80.0％), the difference was statistically significant (P<0.05). There was no significant difference in the safety of the two groups. Conclusion Jieyu Anshen Decoction combined with aripiprazole tablets in the treatment of chronic schizophrenia compared to conventional methods, can improve clinical efficacy, but also has good safety, it is worth clinical reference.