ABSTRACT
Introdução: A esofagite eosinofílica (EEo) eÌ uma doença que está ganhando cada vez mais destaque no cotidiano de gastroenterologistas e alergologistas, visto que sua prevalência vem aumentando e, hoje, eÌ considerada a segunda causa mais comum de esofagite crônica, atrás da doença do refluxo gastroesofágico. A identificação do perfil clínico desses pacientes, da presença de outras doenças atópicas relacionadas ao quadro e o conhecimento dos principais arsenais terapêuticos disponíveis são de grande importância, pois é considerada uma doença relativamente recente, crônica e recidivante, para a qual ainda existem muitas controveÌrsias na literatura atual. Métodos: Estudo observacional retrospectivo, com coleta de dados secundários e abordagem quantitativa. Mediante prontuários de pacientes diagnosticados com EEo atendidos em consultório privado do sul de Santa Catarina de 2015 a 2018. Resultados: Foram incluídos 11 pacientes, com predomínio do sexo feminino (54,5%), idades entre 19 e 34 anos (90,1%), possuindo estado civil solteiro (66,7%). Entre as atopias associadas, ressaltaram-se a alergia alimentar (90,9%) e alergia a animais (54,5%). A maioria com história familiar de manifestações atópicas (81,8%). Quando avaliadas as comorbidades prevalentes, houve predomínio de intolerância à lactose (25%). Realizam algum tratamento para a EEo (100%), predominando uso exclusivo de Inibidores da Bomba de Prótons (IBP) (27,3%). Conclusão: Perfil dos pacientes com EEo atendidos em um consultório privado na região de Criciúma/SC eÌ de mulheres com idade entre 19-34 anos, solteiras, apresentando atopias, principalmente alergia alimentar e alergia a animais, com história familiar de atopias, possuindo intolerância à lactose concomitante e em tratamento para EEo com IBP.
Introduction: Eosinophilic esophagitis (EoE) is a disease progressively gaining prominence in the daily lives of gastroenterologists and allergists since its prevalence has been increasing and, today, it is considered the second most common cause of chronic esophagitis, after the gastroesophageal reflux disease. The identification of the clinical and epidemiological profile of these patients, the presence of other atopic diseases related to the condition, and knowledge of the main therapeutic arsenals available is of great importance since it is considered a relatively recent, chronic, and recidivating disease, for which there are still many controversies in the current literature. Methods: This was a retrospective observational study, with secondary data collection and a quantitative approach. Using medical records of patients diagnosed with EoE seen in private practice in southern Santa Catarina from 2015 to 2018. Results: 11 patients were included, with a predominance of females (54.5%), ages between 19 and 34 years (90.1%), and most single (66.7%). Among the associated atopic manifestations, food allergy (90.9%) and animal allergy (54.5%) stood out. Most had a family history of atopic manifestations (81.8%). After evaluating the prevalent comorbidities, the study found a predominance of lactose intolerance (25%). They underwent some treatment for EoE (100%), predominantly the exclusive use of proton pump inhibitors (PPIs) (27.3%). Conclusion: The epidemiological profile of patients with EoE seen in private practice in the Criciúma region are women aged 19-34 years, single, presenting atopic diseases, mainly food allergy and animal allergy, with a family history of atopic diseases, concomitant lactose intolerance, and being treated for EoE with PPIs.
Subject(s)
Eosinophilic EsophagitisABSTRACT
Atopic diseases used to be considered as complex polygenic diseases with the interaction of environmental factors and genetic susceptibility.In recent years, primary atopic diseases caused by single-gene mutations have been well concerned.This study aims to review the pathogenesis and clinical characteristics of atopic diseases, thus strengthening the understanding.
ABSTRACT
Nephrotic syndrome is a common glomerular disease in childhood and easy to recur.It has been found that children with nephrotic syndrome are often accompanied by atopic manifestations and there is high co-morbidity between nephrotic syndrome and atopic diseases.This article reviewed the pathogenesis, cytokines and treatment of nephrotic syndrome and atopic diseases in children to explore the similarity between them to provide new clues and methods for the treatment of nephrotic syndrome in children.
ABSTRACT
A asma é uma das doenças crônicas mais prevalentes no mundo, sendo que 50% a 80% dos pacientes apresentam o fenótipo alérgico. A asma resulta da interação entre predisposição genética e exposição ambiental. Os aeroalérgenos perenes, especialmente os ácaros da poeira doméstica, são considerados um dos responsáveis pelo aumento da prevalência da asma em todo mundo. O controle ambiental é uma das medidas necessárias para o tratamento e controle da asma.
Asthma is one of the most prevalent chronic diseases worldwide, and 50 to 80% of affected patients have the allergic phenotype. Asthma results from the interaction between genetic predisposition and environmental exposure. Perennial aeroallergens, especially household dust mites, are considered one of the reasons for the increase in the prevalence of asthma worldwide. Environmental control is a necessary measure to treat and control asthma.
Subject(s)
Humans , Asthma , Environmental Monitoring , Disease Prevention , Mites , Patients , Therapeutics , Rhinitis, Allergic, Seasonal , Prevalence , Cockroaches , Environmental Illness , Dust , Allergy and Immunology , FungiABSTRACT
Child atopic disease is a global public health problem.Because it can cause various mental health problems,it is getting more and more attention.In recent decades,the prevalence of child atopic diseases is dramatically increasing,and children's physical and mental health are affected to different degrees.There are several hypotheses about the potential mechanism between atopic diseases and psychological problems.Herein,the psychological and behavioral problems in children with atopic diseases and the associated mechanism will be discussed.Furthermore,it suggests that the professionals should pay more attention to the children's psychosomatic diseases,and pay more attention to the interactive effect between atopic diseases and mental health problems.It is important for the diagnosis,prevention and intervention of children with the psychosomatic diseases.
ABSTRACT
Child atopic disease is a global public health problem.Because it can cause various mental health problems, it is getting more and more attention.In recent decades, the prevalence of child atopic diseases is dramatica-lly increasing, and children′s physical and mental health are affected to different degrees.There are several hypotheses about the potential mechanism between atopic diseases and psychological problems.Herein, the psychological and behavioral problems in children with atopic diseases and the associated mechanism will be discussed.Furthermore, it suggests that the professionals should pay more attention to the children′s psychosomatic diseases, and pay more attention to the interactive effect between atopic diseases and mental health problems.It is important for the diagnosis, prevention and intervention of children with the psychosomatic diseases.
ABSTRACT
It is recently known that attention deficit/hyperactivity disorder(ADHD),which is often recognized in early-school children,may have a close relationship with atopic disease.Furthermore,there are numerous systemic reviews and meta-analysis focusing on the comorbidity of ADHD and atopic disease.However,the mechanism of the comorbidity has remained less well explored.This review aims to gain a better understanding of the relationship between ADHD and atopic disease in children,investigate the hypothesis and relevant studies results about the influences of atopic disease on ADHD,and help the correlative further research to some extent.
ABSTRACT
Objective To investigate the risk of atopic disease in infants with a atopic mothers. Methods The level of CCL22 and total IgE in the cord blood were measured using ELISA for 33 newborns with atopic mothers and for 44 newborns with non-atopic mothers. Correlation between the two factors was examined. Periodic follow-ups were conducted on the newborns to observe the risk of atopic diseases. Results The atopic group showed a higher level of CCL22 than that in non-atopic group, and the difference was statistically significant (Z=5.20, P=0.000). When 0.9 kU/L was taken as the threshold of an elevated IgE level in cord blood, the positive rates of the atopic group (11/33) was much higher than that of the non-atopic group (4/44) (χ2=7.07, P=0.008). Furthermore, the level of CCL22 and the level of IgE were significantly positively correlated (r=0.808, P=0.000; r=0.348, P=0.021) in the atopic group and the non-atopic group, respectively. During the 12 months of follow-up, the number of atopic diseases occurred in the infants in the atopic group (24/33) was much higher than that in the non-atopic group (10/44) (χ2=19.12, P<0.001).Significant correlation exists between levels CCL22 and total IgE in cord blood and infant atopic diseases (Z=5.36, P=0.000; Z=4.44, P=0.000). Conclusions At birth, the infants with an atopic mother are already in a sensitization state and have a tendency to develop potential atopic diseases. There is a correlation between the history of atopic diseases in the mothers and the elevated level of CCL22 in the cord blood of the newborns, and the probability of developing atopic diseases for the newborns is significantly higher when the level of CCL22 is elevated. The combined detection of CCL22 and IgE levels impact significantly on the prediction of the risk of atopic diseases clinically.
ABSTRACT
Las enfermedades alérgicas y el asma, sobre todo en la población infantil, son afecciones muy frecuentes en todo el mundo y en Cuba. Con el objetivo de determinar la frecuencia de sensibilización a hongos ambientales y su relación con enfermedades atópicas, se realizó un estudio analítico transversal en 100 escolares de 6 a 7 años de una escuela primaria de San Antonio de los Baños, provincia La Habana, en el período comprendido entre septiembre de 2006 y marzo de 2007. El 27 por ciento de la muestra seleccionada padecía de asma, el 40 por ciento de rinitis alérgica y el 26 por ciento de dermatitis atópica. La sensibilización micótica más frecuente resultó Penicillium, para un 50 por ciento de la muestra. No hubo una asociación estadísticamente significativa entre reactividad cutánea a hongos ambientales y la presencia de enfermedades atópicas; tampoco fue significativa su asociación con la enfermedad alérgica respiratoria ni dermatitis atópica. Se concluye que la mayor sensibilización a hongos anemófilos se apreció al Penicillium, aunque sin asociación con la presencia de enfermedades atópicas
The allergic diseases and the asthma, mainly in children, are very frequent affections at world level and in Cuba. The objective of present paper was to determine the sensitization frequency to environmental fungi and its relation to atopic diseases, thus, a cross-sectional and analytical study was conducted in 100 school children aged 6 to 7 from a primary school of San Antonio de los Ba±os, La Habana province, from September 2006 to March, 2007. The 27 percent of the selected sample suffered from asthma, the 40 percent of allergic rhinitis, and the 26 percent had Penicillium for the 50 percent of sample. There was not a significant statistic association between the cutaneous reactivity to environmental fungi and the presence of atopic diseases and its association with the respiratory allergic disease as well as the atopic dermatitis was not significant. We conclude that the greater sensitization to anemophilic fungi was to Penicillium, although without an association with the presence of atopic diseases
Subject(s)
Humans , Male , Female , Child , Anti-Allergic Agents , Dermatitis, Atopic/epidemiology , Penicillium/pathogenicity , Cross-Sectional Studies , Skin Tests/methodsABSTRACT
Objetivo: Rever a literatura a respeito do conceito de marcha atópica, suas bases teóricas e evidências clínicas. Tal conhecimento é importante no entendimento e aplicação dos princípios de prevenção primária e secundária das doenças atópicas. Fontes dos dados: Pesquisa bibliográfica em base eletrônica de dados, limitando a busca a artigos publicados nos últimos 15 anos, referentes a pesquisas ou estudos clínicos em seres humanos e estudos experimentais, escritos em português ou inglês. Referências a livros pertinentes ao tema também foram incluídas. Foram selecionados os artigos mais citados e com metodologia e discussão melhor estruturados dentro do tema dermatite atópica / marcha atópica. Síntese dos dados: O conceito de marcha atópica é uma tentativa de se explicar a inter-relação entre as doenças atópicas, assim como as características da história natural de cada uma delas. Tal conceito baseia-se em estudos clínicos que demonstraram que, em cerca de 50% dos indivíduos predispostos, as doenças atópicas ocorrem de forma seqüencial, sendo a dermatite atópica considerada como o primeiro passo desta marcha. Conclusões: A partir de dados coletados em estudos sobre prevalência de doenças atópicas e os possíveis fatores determinantes envolvidos no desenvolvimento das mesmas, princípios de prevenção primária e secundária podem ser recomendados e implementados.
Objective: To review the literature on atopic march concept, its theoretical basis and clinicai evidences. This knowledge is important to understand and to apply the principies of primary and secondary atopic diseases prevention. Data sources: A bibliographic search was done in electronic database, limited to articles published in the last 15 years, related to human research or experimental research, written in Portuguese or English. Some book relevant references were also included. The articles about atopic dermatitis and atopic march were selected according to the number of citation and the better methodology and discussion. Data synthesis: The atopic march concept is a trial to explain the relationship between the atopic diseases and the natural evolution of each one. Clinicai researches have demons¬trated that in something about 50% of predisposed individual, the atopic diseases occurred in a sequence way, being the atopic dermatitis the first step in this marcho Conclusions: Principies of primary e secondary prevention can be recommended and implemented after review the data collected in studies about prevalence of atopic diseases and the factors involved in the development of such diseases.
Subject(s)
Humans , Child , Asthma , Dermatitis, Atopic , Hypersensitivity, Immediate , Immunoglobulin E , Rhinitis , Critical Pathways , Methods , PrevalenceABSTRACT
Several studies have shown that decreased IFN γ or increased IL 4 secretion by Tcells are associated with allergy and these can predict the development of atopic diseases. We compared the production of IL 4 and IFN γ in atopic Thai children with appropriate controls. Twenty five atopic patients and twenty four non-atopic subjects were enrolled. Production of IFN γ and IL 4 by peripheral blood mononuclear leukocytes was measured under stimulating conditions (phorbol myristate acetate). The atopic group comprised 6 atopic asthmatics and 19 allergic rhinitis patients. The results showed no significant difference in the IFN γ/ IL 4 ratio between atopic asthmatics, and allergic rhinitis patients and controls. However, the difference between asthmatics and controls was larger than between the other groups. In this study, a nonsignificant trend of overproduction of IL 4 compared with IFN γ is shown only in asthmatic children as compared to those with rhinitis and controls.