EFFECTS OF RESERPINE ON AURICLE OF GUINEA PIG / 西安交通大学学报(医学版)

Effects of reserpine on the physiologic properties of myocardium were studied in the auricle of quinea pig. Reserpine (10 ?M) decreased the contractive force of the left auricle to 57 ?15% (P0.05) in the left auricle of guinea pig, Reserpine shifted the dose-response curve of epinephrine positive frequency non-parallelly to the right with decrease of its maximum effect. It also possessed antagonistic effect for calcium positive frequency response. The results obtained indicate that reserpine might possesse calcium antagonistic effect.