ABSTRACT
Autophagy is a cellular normal reaction to cope with the changes in internal and external environmental pressure, and a degradation process of the material composition. Recent studies have shown that autophagy is closely related to the growth and physiological and pathological events of podocytes in kidneys and it is a potential target for the treatment of diabetic nephropathy(DN) and a self-protection mechanism. Rregulation of autophagy can affect some signaling pathways in the development of DN. Thus ,we summarize the pathogenesis of DN,the role of autophagy in the intrinsic kidney cells,and the effect of autophagy on some signaling pathways in the development of DN in this review.
ABSTRACT
Autophagy is a cellular normal reaction to cope with the changes in internal and external environmental pressure, and a degradation process of the material composition. Recent studies have shown that autophagy is closely related to the growth and physiological and pathological events of podocytes in kidneys and it is a potential target for the treatment of diabetic nephropathy (DN) and a self-protection mechanism. Rregulation of autophagy can affect some signaling pathways in the development of DN. Thus, we summarize the pathogenesis of DN, the role of autophagy in the intrinsic kidney cells, and the effect of autophagy on some signaling pathways in the development of DN in this review.
ABSTRACT
Autophagy is a cellular reaction to the changes of internal and external environmental pressure, and a degradation process of the material composition. Recent study has shown that autophagy is closely related to the quantity and insulin secretion of pan-creaticβcell. As a self-protection mechanism, the activation and regulation of autophagy are essential for maintaining the structure and function of pancreaticβcells in type 2 diabetes. Moreover, some drugs for type 2 diabetes were found to participate in the regulation of autophagy pathway in recent studies. Thus, in this review we summarize the importance of autophagy in protecting the structure and func-tion of pancreaticβcell, the regulation of autophagy pathway and the correlation between autophagy and drugs for type 2 diabetes.
ABSTRACT
Autophagy is a cellular reaction to the changes of internal and external environmental pressure, and a degradation process of the material composition. Recent study has shown that autophagy is closely related to the quantity and insulin secretion of pancreatic β cell. As a self-protection mechanism, the activation and regulation of autophagy are essential for maintaining the structure and function of pancreatic β cells in type 2 diabetes. Moreover, some drugs for type 2 diabetes were found to participate in the regulation of autophagy pathway in recent studies. Thus, in this review we summarize the importance of autophagy in protecting the structure and function of pancreatic β cell, the regulation of autophagy pathway and the correlation between autophagy and drugs for type 2 diabetes.