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1.
Rev. chil. infectol ; 34(2): 133-140, abr. 2017. ilus, tab
Article in Spanish | LILACS | ID: biblio-844457

ABSTRACT

Background: Occult bacteremia (OB) is one of the possible diagnoses of children younger than 3 years with fever without source in the emergency room. Objective: describe OB in the era after introduction of pneumococcal vaccine in Chile. Patients and Methods: Prospective descriptive review of data of children with possible OB diagnosis, referred from the emergency department between 2010-2013. Results: Possible OB was diagnosed on 391 patients. 233 had focus, mainly respiratory virus and urinary tract infection. On 158 patients, probable BO was diagnosed, 20 had proven OB from which 15 had positive blood culture for Streptococcus pneumoniae. From these, 7 were fully or partially vaccinated. The serotype was identified on 14 cases: 6 were PCV10 vaccine serotypes (none of them vaccinated), 2 were serotype related (both partially vaccinated) and 6 were non vaccine serotypes (partially or totally vaccinated). Discussion: It is necessary to improve diagnostic methods for respiratory viruses and urinary tract infections and try to expand coverage of pneumococcal conjugated vaccines in the pediatric population in order to reduce the risk of invasive pneumococcal disease in Chile.


Introducción: La bacteriemia oculta (BO) es uno de los diagnósticos que se plantean en los niños bajo 3 años de edad que se presentan con fiebre sin foco en el servicio de urgencia. Objetivo: Describir el diagnóstico de BO luego de la introducción de la vacunación universal para Streptococcus pneumoniae en Chile. Materiales y Métodos: Revisión descriptiva de seguimiento prospectivo de datos de niños con diagnóstico de BO posible derivados del SU entre 2010 y 2013. Resultados: Se diagnosticó BO posible en 391 pacientes. En 233 pacientes se encontró foco, siendo infecciones respiratorias virales e infección urinaria las más frecuentes. En 158 pacientes se diagnosticó BO probable, en 20 BO probada y 15 tuvieron hemocultivos positivos para S. pneumoniae. De estos últimos 7 estaban total o parcialmente vacunados. Se identificó serotipo en 14 casos: 6 serotipos vaccinales incluidos en PCV10 (ninguno vacunado), 2 serotipos relacionados (ambos parcialmente protegido) y 6 serotipos no vaccinales (parcial o totalmente vacunados). Discusión: Es necesario mejorar las técnicas diagnósticas de infecciones respiratorias virales e infección urinaria e intentar ampliar la cobertura de las vacunas neumocóccicas conjugadas en la población pediátrica, para reducir el riesgo de enfermedades neumocóccicas invasoras en Chile.


Subject(s)
Humans , Infant , Child, Preschool , Pneumococcal Infections/microbiology , Respiratory Tract Infections/microbiology , Urinary Tract Infections/microbiology , Bacteremia/microbiology , Heptavalent Pneumococcal Conjugate Vaccine/administration & dosage , Pneumococcal Infections/prevention & control , Chile , Prospective Studies , Bacteremia/prevention & control
2.
Medisan ; 15(10)oct. 2011. tab
Article in Spanish | LILACS | ID: lil-616376

ABSTRACT

Se realizó un estudio descriptivo y transversal para caracterizar, desde los puntos de vista clínico y epidemiológico, a 71 pacientes de 3 a 36 meses de edad con fiebre sin foco infeccioso evidente, ingresados en el Hospital Infantil Norte Dr Juan de la Cruz Martínez Maceira de Santiago de Cuba durante el 2010. En la casuística predominaron el sexo masculino (60,4 por ciento), las edades de 3 a 6 meses (43,6 por ciento), la fiebre elevada (62,0 por ciento) y el aspecto normal (94,3 por ciento), con leucocitosis en 53,5 por ciento y velocidad de sedimentación globular acelerada en 67,5 por ciento. Los niños y niñas egresaron básicamente con diagnóstico de bacteriemia oculta (25,3 por ciento), luego de haber sido tratados preponderantemente con cefalosporinas de tercera generación (50,6 por ciento).


A descriptive and cross-sectional study was carried out to characterize from the clinical and epidemiological points of view 71 patients aged 3 to 36 months admitted to Dr Juan de la Cruz Martínez Maceira Northern Children Hospital of Santiago de Cuba due to fever without apparent infectious source during 2010. Male sex (60,4 percent), ages between 3 and 6 months (43,6 percent), high temperature (62,0 percent) and normal appearance (94,3 percent) with 53,5 percent leukocytosis and accelerated erythrocyte sedimentation rate in 67,5 percent prevailed in our cases. Children were basically discharged with diagnosis of hidden bacteriemia (25,3 percent) after being treated predominantly with third-generation cephalosporins (50,6 percent).


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Bacteremia , Cephalosporins , Fever , Focal Infection , Secondary Care , Cross-Sectional Studies , Epidemiology, Descriptive
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