Basaloid squamous cell carcinoma in gingiva: a case report / 华西口腔医学杂志

As an aggressive subtype of squamous cell carcinoma, basaloid squamous cell carcinoma (BSCC) rarely occurs in the oral and maxillofacial region. The gingiva is an unusual site of BSCC. This study reported a 78-year-old male who presented with left maxillary pain. Clinical examination revealed a gingival mass in the left maxilla. Under microscope, the lesion showed typical comedo necrosis and peripheral palisading. Areas of glandular-like structures were also observed. Immunohistochemistry results revealed that the Ki-67 score of BSCC in this case was 28%, and S-100 was positive in some areas. However, P16 and CK7 were negative. Finally, a diagnosis of BSCC was made based on the pathological and immunohistochemical characteristics. The patient underwent subtotal maxillectomy. After 12 months later, the patient was alive with no evidence of disease. Combined with relevant literature, this article analyzed the clinicopathological features, differential diagnosis, diagnosis, treatment, and prognosis of BSCC. Although surgery remains the main treatment in the head and neck region, radiation-chemotherapy should be considered in some human papilloma virus-positive cases.

Basaloid Squamous Cell Carcinoma of Oesophagus: Definitely Rare but does it Differs Significantly from the Conventional Squamous Cell Carcinoma.

Introduction: Basaloid squamous cell carcinoma (BSCC)is a rare, poorly differentiated variant of squamous cellcarcinoma (SCC). The diagnosis is made only after exclusionof conventional squamous cell carcinoma, adenoid cysticcarcinoma and small cell carcinoma. Our aim is to presenttwo cases of BSCCs identified in oesophagus with detailedclinicopathological, histological and immunohistochemicalfindings for better understanding of this rare entity which haslimited literature available to avoid misdiagnosis.Case Report: A detailed study of clinical and pathologicparameters in two cases of BSCC reported in our departmentwho had underwent potentially curative surgical resectionafter a preliminary post biopsy diagnosis was made.Microscopically, both the cases showed a quite similarpicture; they were composed of relatively small tumour cells,arranged in solid lobules with abundant comedo- necrosis.However, there were some minor variations as one of themwas accompanied by large areas of typical conventional SCC,whereas the other one showed presence of bizarre cells. Onimmunohistochemical analysis, the tumour cells showedstrong positivity for pan-CK with a high Ki67 index of 80-85%.Conclusion: BSCC have a poorer prognosis than conventionaloesophageal squamous cell carcinoma, but no definitivespecific treatment protocol has been established till date.Still these cases were considered worthy of discussion due tothe distinctness of this entity especially considering the siteoesophagus where it is regarded to be quite rare, in addition toits aggressiveness and poor outcome.

HPV related cloacogenic carcinoma of the anal canal with divergent histomorphology

Cloacogenic carcinoma also known as basaloid squamous cell carcinoma is a rare anorectal tumor presenting with varied histomorphology. In this case report, we describe a case of 58-year-old man presenting with bleeding per rectum and pain. A polypoidal tumor was noted in anal canal which on microscopy was diagnosed to be cloacogenic carcinoma with transitional carcinoma-like, basaloid and mucinous patterns. An unusual finding in the present case was the presence of signet ring cells in the mucinous areas. A thorough knowledge of the wide histomorphological spectrum of the tumor and a limited IHC panel are crucial for the diagnosis. Here, we also present a review of literature and describe in detail the origin and histopathological features of the tumor.

Endoscopic Features of Basaloid Squamous Cell Carcinoma of Esophagus at Early Stage / 胃肠病学

Background: Esophageal basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma characterized by aggressive biological behavior and poor prognosis. Curative resection at early stage can significantly improve the outcome of patients with esophageal BSCC. Endoscopic biopsy is the main approach for the diagnosis of early esophageal cancer, however, the endoscopic features of early esophageal BSCC have not yet been systematically studied. Aims: To summarize the endoscopic features of early esophageal BSCC. Methods: The clinical, endoscopic and pathological data of 5 cases of early esophageal BSCC confirmed by pathology of endoscopic submucosal dissection from June 2016 to March 2019 at the Affiliated Drum Tower Hospital of Nanjing University Medical School were retrospectively analyzed. Results: The patients were 5 males with a mean age of 61 years old. Most of the lesions were located in the middle thoracic esophagus (3/5); the long diameter was equal to or more than 3 cm (4/5), and near 50% circumference of the esophagus was involved (5/5). All of the 5 lesions were presented as endoscopic type Ⅱb. Most of the lesions showed only mucosal roughness under white light endoscopy and there were no obvious demarcation or background color changes under narrow-band imaging. Intrapapillary capillary loop (IPCL) was categorized as type B1 with low density under magnifying endoscopy in four cases. Iodine staining revealed less-stained or no staining in all the cases. Postoperative pathological results showed T1a tumor in all the cases. Conclusions: The endoscopic findings of early esophageal BSCC were occult. Most of the cases only show rough and flat lesion without other obvious specific changes. Type B1 microvessels with a low density under magnifying endoscopy might be a characteristic feature of early esophageal BSCC.

Carcinoma de células escamosas basaloide en paladar: Reporte de caso

l carcinoma de células escamosas basaloide (CCEB) es una variante poco común y agresiva del carcinoma de células escamosas (CCE), con predilección por el tracto aerodigestivo superior, siendo el paladar un sitio muy raro de desarrollo. Está constituido por un componentes basaloide y uno escamoso en proporciones variables, sin embargo, las características histopatológicas del CCEB se superponen con otras neoplasias. El diagnóstico con diversos marcadores inmunohistoquímicos como p63, Ki67, p16, y citoqueratinas AE1 / AE3 se han convertido en una necesidad para el especialista. El objetivo de este trabajo es presentar un caso de CCEB en paladar blando y evidenciar la importancia del apoyo en la Iinmunohistoquímica para un diagnóstico histopatológico precoz. Se presenta además una revisión de literatura en cuanto a esta patología.

asaloid Squamous Cell Carcinoma (BSCC) is a rare and aggressive variant of squamous cell carcinoma (SCC), with a predilection for the upper aerodigestive tract, the palate being a very rare site of development. It is constituted by a basaloid and a squamous components in variable proportions, however, the histopathological characteristics of the BSCC overlap with other neoplasias. Diagnosis with various immunohistochemical markers such as p63, Ki67, p16, and AE1 / AE3 cytokeratins have become a necessity for the specialist. The objective of this study is to present a case of BSCC in soft palate and to show the importance of the support in the immunohistochemistry for an early histopathological diagnosis. A review of the literature on this pathology is also presented.

Basaloid Squamous Cell Carcinoma in Nasal Cavity

Basaloid squamous cell carcinoma (BSCC) is often founded in the head and neck region. However, BSCC in the sinonasal tract is rare. We report here on the case of a 58-yr-old woman who presented with nasal obstruction and epistaxis. Computed tomography and examination of the nasal cavity revealed a tumor mass that originated from the right inferior turbinate with erosion of the nasal floor. The tumor that was attached to the inferior turbinate, the lateral nasal wall and the eroded right side hard palate, and so all this was resected. Histopathologic examination of the excised tumor confirmed BSCC in the nasal cavity. We report here on a nasal cavity BSCC that was treated with partial maxillectomy only.

Basaloid squamous cell carcinoma in the maxillary sinus

Basaloid squamous cell carcinoma (BSCC) is uncommon and distinct variant of squamous cell carcinoma that arises mostly in the upper aerodigestive tract and aggressive, high grade tumor with an increased tendency to be deeply invasive, multifocal, and metastatic even at the initial presentation. The typical microscopic features of carcinoma with a basaloid pattern in intimate association with a squamous component helps in diagnosis of this tumour. Since Wain's report in 1986, BSCC of oral cavity, the palate, floor of the mouth, nasopharynx, oropharynx and mastoid region have been reported. However, BSCC in the nasal cavity or in the paranasal sinuses is rare and there are few reports in the Korean literature. We had experienced a case of basaloid squamous cell carcinoma that occurred in the left maxillary sinus of 72-year-old woman and reported with review of the clinical and pathologic features from the literature.

Basaloid Squamous Cell Carcinoma of the Rectum Manifesting as Multiple Submucosal Lesions / 대한소화기내시경학회지

Basaloid squamous carcinoma is a rare, pooly differentiated variant of squamous cell carcinoma. It occurs in various sites, including the upper digestive tract, the esophagus, lung, anus, cervix and thymus. It has been postulated that basaloid carcinoma may arise from outside of the anal canal, such as at where the cloacogenic embryologic cells rest, the squamous metaplastic epithelium, or the totipotential basal cells. This tumor is a distinct entity that should be carefully distinguished from basal cell carcinomas of the anal canal, which is a condition that has a very good prognosis, and anal or perianal squamous cell carcinomas, which have a different path of spread and they vary considerably in their behavior. We report here on a patient with basaloid squamous carcinoma in the distal rectum that manifested as multiple submucosal lesions, and the patient presented with abdominal pain and blood tinged stool.

A Case of Basaloid Squamous Cell Carcinoma Extended to the Temporal Bone / 대한이비인후과학회지

Basaloid squamous cell carcinoma (BSCC), an uncommon tumor with predilection for the upper aerodigestive tract, is a distinct variant of squamous cell carcinoma, because of its unique histological features and ominous clinical behavior. Basaloid squamous cell carcinoma is a high-grade variant of squamous cell carcinoma. Reports subsequent to its initial description in 1986 by Wain et al. have confirmed that the head and neck region is the most frequently involved region, with majority of the cases arising in the supraglottic larynx, hypopharynx, tonsil and base of tongue. Other head and neck sites include the palate, buccal cavity, floor of mouth, nasopharynx, trachea, and sinonasal tract. BSCC is not limited to the head and neck region but has also been described in the esophagus, lung, thymus, anus and cervix among other sites. We experienced and treated a case of BSCC extended to the temporal bone with characteristic histopathologic and immunologic features. Therefore, we report here the rare case of BSCC invading the temporal bone with literature.

A Case of Basaloid Squamous Cell Carcinoma Occurring in the Mobile Tongue / 대한이비인후과학회지

Basaloid squamous cell carcinoma is a rare variant of squamous cell carcinoma mainly occurring in the tongue base, hypopharynx, larynx and the mouth floor. Histologically, this tumor has two cell types, the basaloid cell and the squamous cell. Prognosis of this tumor was reported to be worse than that of squamous cell carcinoma due to its aggressive behavior. We experienced a case of basaloid squamous cell carcinoma in the mobile tongue, which had no mucosal involvement.

A Case of Spontaneous Regression of Basaloid Squamous Cell Carcinoma / 대한이비인후과학회지

Basaloid squamous cell carcinoma(BSCC) is a rare distant variant of squamous cell carcinoma of head and neck region, of which about 90 cases was reported in the world. BSCC has aggressive biologic behavior with a high incidence of cervical lymph node metastasis, distant spread, and death from disease. S pontaneous regression has not been previously reported in BSCC. However, we experienced a case of spontaneous regression of BSCC in nasal cavity with characteristic histopathologic and immunologic feature in 53 old male patient. T herefore, we report the first case of spontaneous regression of BSCC.