ABSTRACT
Rheumatoid arthritis is an autoimmune inflammatory rheumatism that affects many organs and tissues. With the advances in technology and research methods, the metabolomics of rheumatoid arthritis has made some progress. This article reviews the application of metabolomics in early biomarker screen-ing and pathogenesis of rheumatoid arthritis, so as lo provide reference for the prevention, diagnosis and treatment of the disease.
ABSTRACT
With the development of whole genome and transcrip-tome sequencing technologies, a growing body of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) has been i-dentified and is receiving increasing attention. LncRNAs and circRNAs are non-protein encoding transcripts whose functions are crucial for advancing our comprehensive understanding of bi-ological processes in human health and diseases, specifically tumor. And there is a close relationship between circRNAs and lncRNAs in their origin and function. In this paper, we have re-viewed the recent advances of lncRNAs and circRNAs in tumor by focusing on their relationships, which may help to distinguish them and identify tumor biomarkers further.
ABSTRACT
Recently,programmed cell death 1/programmed cell death 1 ligand(PD-1/PD-L1)blockade has elicited clinical re-sponses and long-term remissions in a subset of patients with a broad spectrum of cancers. Unfortunately,a substantial number of pa-tients failed to respond to PD1/PD-L1 blockade. In this paper,we summarize our current understanding of the key factors accounting for the difference on treatment,and evaluate the dependability of several potential predictive biomarkers guiding PD1/PD-L1 blockade in cancer therapy. We also discuss a variety of combined treatments based on PD1/PD-L1 blockade.